Dominant-negative Effects of COL7A1 Mutations Can be Rescued by Controlled Overexpression of Normal Collagen VII

Autor: Anja Fritsch, Susanne Elfert, Guerrino Meneguzzi, Leena Bruckner-Tuderman, Sashko Spassov, Yannick Gache, Andreas Schlosser

Publikováno v: Journal of Biological Chemistry. 284:30248-30256

Dominant-negative interference by glycine substitution mutations in the COL7A1 gene causes dominant dystrophic epidermolysis bullosa (DDEB), a skin fragility disorder with mechanically induced blistering. Although qualitative and quantitative alterat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2068400f6ff12907a21b83b304862c
https://doi.org/10.1074/jbc.m109.045294

A hypomorphic mouse model of dystrophic epidermolysis bullosa reveals mechanisms of disease and response to fibroblast therapy

Autor: Anja Fritsch, Hauke Schumann, Thorsten A. Bley, Dominik von Elverfeldt, Johannes S. Kern, Miriam Erlacher, S. Loeckermann, Leena Bruckner-Tuderman, Ingrid Hausser, Michael R. Bösl, Dominik Paul, Dirk Berens von Rautenfeld, Reinhard Fässler, Attila Braun

Publikováno v: Journal of Clinical Investigation. 118:1669-1679

Dystrophic epidermolysis bullosa (DEB) is a severe skin fragility disorder associated with trauma-induced blistering, progressive soft tissue scarring, and increased risk of skin cancer. DEB is caused by mutations in type VII collagen. In this study,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42316a0ecf289fe2d3653c45f292ca33
https://doi.org/10.1172/jci34292

Extracellular Phosphorylation of Collagen XVII by Ecto-Casein Kinase 2 Inhibits Ectodomain Shedding

Autor: Anja Fritsch, Elena P. Zimina, Thomas Benzing, Mikhail Bashkurov, Bernhard Schermer, Leena Bruckner-Tuderman, Anastasia Bakulina

Publikováno v: Journal of Biological Chemistry. 282:22737-22746

Ecto-phosphorylation is emerging as an important mechanism to regulate cellular ligand interactions and signal transduction. Here we show that extracellular phosphorylation of the cell surface receptor collagen XVII regulates shedding of its ectodoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5537893f3cff949dc59064bbfa0e52
https://doi.org/10.1074/jbc.m701937200

Collagen VII plays a dual role in wound healing

Autor: Leena Bruckner-Tuderman, Anja Fritsch, Daniela Velati, Venugopal Rao Mittapalli, Alexander Nyström, Johannes S. Kern

Publikováno v: The Journal of clinical investigation. 123(8)

Although a host of intracellular signals is known to contribute to wound healing, the role of the cell microenvironment in tissue repair remains elusive. Here we employed 2 different mouse models of genetic skin fragility to assess the role of the ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab2bd8b0645f276858234088afe7039b
https://pubmed.ncbi.nlm.nih.gov/23867500

PI3Kβ Plays a Critical Role in Neutrophil Activation by Immune Complexes

Autor: Misa Hirose, David Oxley, Detlef Zillikens, Anja Fritsch, Tamara Chessa, Bart Vanhaesebroeck, Faruk Ramadani, Len R. Stephens, Anne Segonds-Pichon, Phillip T. Hawkins, Keith Davidson, Hervé Guillou, Ralf Ludwig, Jatinder K. Juss, Zoltán Jakus, Suhasini Kulkarni, Karen E. Anderson, Klaus Okkenhaug, Gavin E. Jarvis, Cassian Sitaru, George Damoulakis, Attila Mócsai

Publikováno v: Science Signaling
Science Signaling, American Association for the Advancement of Science, 2011, 4 (168), pp.ra23. ⟨10.1126/scisignal.2001617⟩

International audience; Neutrophils are activated by immunoglobulin G (IgG)-containing immune complexes through receptors that recognize the Fc portion of IgG (Fc gamma Rs). Here, we used genetic and pharmacological approaches to define a selective r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88fb6018cfc23891a76d6c644dc6f3e7
https://doi.org/10.1126/scisignal.2001617