Zobrazeno 1 - 10
of 325
pro vyhledávání: '"Anja Feldmann"'
Autor:
Liliana R. Loureiro, Lydia Hoffmann, Christin Neuber, Luise Rupp, Claudia Arndt, Alexandra Kegler, Manja Kubeil, Christoph E. Hagemeyer, Holger Stephan, Marc Schmitz, Anja Feldmann, Michael Bachmann
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-17 (2023)
Abstract Background Chimeric antigen receptor (CAR) T-cells are a promising approach in cancer immunotherapy, particularly for treating hematologic malignancies. Yet, their effectiveness is limited when tackling solid tumors, where immune cell infilt
Externí odkaz:
https://doaj.org/article/40cdac5b7b9a489091bc53905b399ab5
Autor:
Hugo Boutier, Liliana R. Loureiro, Lydia Hoffmann, Claudia Arndt, Tabea Bartsch, Anja Feldmann, Michael P. Bachmann
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7242 (2024)
Although Chimeric Antigen Receptor (CAR) T-cells have shown high efficacy in hematologic malignancies, they can cause severe to life-threatening side effects. To address these safety concerns, we have developed adaptor CAR platforms, like the UniCAR
Externí odkaz:
https://doaj.org/article/3d04a978770a477bbd3bf64f6866c27a
Autor:
Torsten Tonn, Hans Klingemann, Winfried S Wels, Jiri Eitler, Natalie Wotschel, Laurent Boissel, Michael Bachmann, Wiebke Rackwitz, Venugopal Gudipati, Nivedha Murali Shankar, Anastasia Sidorenkova, Johannes B Huppa, Paola Ortiz-Montero, Corinna Opitz, Stephan R Künzel, Susanne Michen, Achim Temme, Liliana Rodrigues Loureiro, Anja Feldmann
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 2 (2024)
Background The antitumor activity of natural killer (NK) cells can be enhanced by specific targeting with therapeutic antibodies that trigger antibody-dependent cell-mediated cytotoxicity (ADCC) or by genetic engineering to express chimeric antigen r
Externí odkaz:
https://doaj.org/article/635e8a9c7ed146e6934cedabb216012a
Autor:
Karla E. G. Soto, Liliana R. Loureiro, Tabea Bartsch, Claudia Arndt, Alexandra Kegler, Nicola Mitwasi, Laura Drewitz, Lydia Hoffmann, Haidy A. Saleh, Eugenia Crespo, Maria Mehnert, Cansu Daglar, Hinrich Abken, Frank Momburg, Michael Bachmann, Anja Feldmann
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Despite the success of chimeric antigen receptor (CAR) T-cells especially for treating hematological malignancies, critical drawbacks, such as “on-target, off-tumor” toxicities, need to be addressed to improve safety in translating to clinical ap
Externí odkaz:
https://doaj.org/article/504decca751c445b97cdaa60cf18debc
Autor:
Alexandra Kegler, Laura Drewitz, Claudia Arndt, Cansu Daglar, Liliana Rodrigues Loureiro, Nicola Mitwasi, Christin Neuber, Karla Elizabeth González Soto, Tabea Bartsch, Larysa Baraban, Holger Ziehr, Markus Heine, Annabel Nieter, Andres Moreira-Soto, Arne Kühne, Jan Felix Drexler, Barbara Seliger, Markus Laube, Domokos Máthé, Bernadett Pályi, Polett Hajdrik, László Forgách, Zoltán Kis, Krisztián Szigeti, Ralf Bergmann, Anja Feldmann, Michael Bachmann
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to millions of infections and deaths worldwide. As this virus evolves rapidly, there is a high need for treatment options that
Externí odkaz:
https://doaj.org/article/6f9dbf914b914345892894df2414c939
Autor:
Haidy A. Saleh, Nicola Mitwasi, Martin Ullrich, Manja Kubeil, Magali Toussaint, Winnie Deuther-Conrad, Christin Neuber, Claudia Arndt, Liliana R. Loureiro, Alexandra Kegler, Karla Elizabeth González Soto, Birgit Belter, Claudia Rössig, Jens Pietzsch, Marcus Frenz, Michael Bachmann, Anja Feldmann
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Glioblastoma (GBM) is still an incurable tumor that is associated with high recurrence rate and poor survival despite the current treatment regimes. With the urgent need for novel therapeutic strategies, immunotherapies, especially chimeric antigen r
Externí odkaz:
https://doaj.org/article/869c24c8ece440448383f3d31672b966
Autor:
Anja Feldmann, Yvonne Nitschke, Franziska Linß, Dennis Mulac, Sina Stücker, Jessica Bertrand, Insa Buers, Klaus Langer, Frank Rutsch
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16471 (2023)
Calcified aortic valve disease in its final stage leads to aortic valve stenosis, limiting cardiac function. To date, surgical intervention is the only option for treating calcific aortic valve stenosis. This study combined controlled drug delivery b
Externí odkaz:
https://doaj.org/article/03d63713732141ffae7a1eef49cb24e7
Autor:
Claudia Arndt, Antje Tunger, Rebekka Wehner, Rebecca Rothe, Eleni Kourtellari, Stephanie Luttosch, Katharina Hannemann, Stefanie Koristka, Liliana R. Loureiro, Anja Feldmann, Torsten Tonn, Theresa Link, Jan Dominik Kuhlmann, Pauline Wimberger, Michael Philipp Bachmann, Marc Schmitz
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor palbociclib is an emerging cancer therapeutic that just recently gained Food and Drug Administration approval for treatment of estrogen receptor (ER)-positive, human epidermal growth factor recep
Externí odkaz:
https://doaj.org/article/d050e2b4207a49ff823ba99d4383286d
Autor:
Franziska Striese, Christin Neuber, Sandy Gräßel, Claudia Arndt, Martin Ullrich, Jörg Steinbach, Jens Pietzsch, Ralf Bergmann, Hans-Jürgen Pietzsch, Wiebke Sihver, Marcus Frenz, Anja Feldmann, Michael P. Bachmann
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9420 (2023)
Prostate specific membrane antigen (PSMA) is an excellent target for imaging and treatment of prostate carcinoma (PCa). Unfortunately, not all PCa cells express PSMA. Therefore, alternative theranostic targets are required. The membrane protein prost
Externí odkaz:
https://doaj.org/article/f1f82be2f6d34d6085c004a44449232e
Autor:
Fabian Krutzek, Cornelius K. Donat, Martin Ullrich, Kristof Zarschler, Marie-Charlotte Ludik, Anja Feldmann, Liliana R. Loureiro, Klaus Kopka, Sven Stadlbauer
Publikováno v:
Cancers, Vol 15, Iss 9, p 2638 (2023)
Noninvasive molecular imaging of the PD-1/PD-L1 immune checkpoint is of high clinical relevance for patient stratification and therapy monitoring in cancer patients. Here we report nine small-molecule PD-L1 radiotracers with solubilizing sulfonic aci
Externí odkaz:
https://doaj.org/article/9130097e494d4042ab799e179758d858