Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Anja F. Hohmann"'
Autor:
Anand S. Bhagwat, Jae-Seok Roe, Beverly Y.L. Mok, Anja F. Hohmann, Junwei Shi, Christopher R. Vakoc
Publikováno v:
Cell Reports, Vol 15, Iss 3, Pp 519-530 (2016)
The bromodomain and extraterminal (BET) protein BRD4 can physically interact with the Mediator complex, but the relevance of this association to the therapeutic effects of BET inhibitors in cancer is unclear. Here, we show that BET inhibition causes
Externí odkaz:
https://doaj.org/article/7d3b08a671c740319cfd6396a1b63777
Autor:
Eric Wang, Shinpei Kawaoka, Jae-Seok Roe, Junwei Shi, Anja F Hohmann, Yali Xu, Anand S Bhagwat, Yutaka Suzuki, Justin B Kinney, Christopher R Vakoc
Publikováno v:
eLife, Vol 4 (2015)
Most mammalian transcription factors (TFs) and cofactors occupy thousands of genomic sites and modulate the expression of large gene networks to implement their biological functions. In this study, we describe an exception to this paradigm. TRIM33 is
Externí odkaz:
https://doaj.org/article/27863118c8f1495d93f82f9e13abfd0c
Autor:
Christopher R. Vakoc, Junwei Shi, Anand S. Bhagwat, Anja F. Hohmann, Jae Seok Roe, Beverly Y.L. Mok
Publikováno v:
Cell Reports, Vol 15, Iss 3, Pp 519-530 (2016)
SummaryThe bromodomain and extraterminal (BET) protein BRD4 can physically interact with the Mediator complex, but the relevance of this association to the therapeutic effects of BET inhibitors in cancer is unclear. Here, we show that BET inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::445cda7a324a2a7c32ebb9e59247909a
Autor:
Christopher R. Vakoc, Anja F. Hohmann
Publikováno v:
Trends in Genetics. 30:356-363
SWI/SNF is a multisubunit chromatin-remodeling complex that performs fundamental roles in gene regulation, cell lineage specification, and organismal development. Mutations that inactivate SWI/SNF subunits are found in nearly 20% of human cancers, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7baf46ab414f77dfcae1491e7d20e34c
https://doi.org/10.1016/j.tig.2014.05.001
https://doi.org/10.1016/j.tig.2014.05.001
Autor:
Mark Pearson, Christopher R. Vakoc, Laetitia J. Martin, Manfred Koegl, Yutaka Suzuki, Thomas Gerstberger, Anja F. Hohmann, Jae Seok Roe, Jessica L. Minder, Steffen Steurer, Junwei Shi, Gerd Bader, Teresa Gottschamel, Darryl B. McConnell, Diane Thompson
Publikováno v:
Nature chemical biology
Here we show that acute myeloid leukemia (AML) cells require the BRD9 subunit of the SWI-SNF chromatin-remodeling complex to sustain MYC transcription, rapid cell proliferation and a block in differentiation. Based on these observations, we derived s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea9c3d2561931d41d3a0fe176c3bece9
https://pubmed.ncbi.nlm.nih.gov/27538023
https://pubmed.ncbi.nlm.nih.gov/27538023
Autor:
Eric Wang, Justin B. Kinney, Yali Xu, Junwei Shi, Shinpei Kawaoka, Yutaka Suzuki, Jae Seok Roe, Anand S. Bhagwat, Anja F. Hohmann, Christopher R. Vakoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::044924802c154267e223f9b80073d356
https://doi.org/10.7554/elife.06377.022
https://doi.org/10.7554/elife.06377.022
Autor:
Shinpei Kawaoka, Eric Wang, Justin B. Kinney, Christopher R. Vakoc, Anand S. Bhagwat, Anja F. Hohmann, Yali Xu, Junwei Shi, Yutaka Suzuki, Jae Seok Roe
Publikováno v:
eLife
eLife, Vol 4 (2015)
eLife, Vol 4 (2015)
Most mammalian transcription factors (TFs) and cofactors occupy thousands of genomic sites and modulate the expression of large gene networks to implement their biological functions. In this study, we describe an exception to this paradigm. TRIM33 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f77729ec258fa7b57725bdff9ce3e168
https://pubmed.ncbi.nlm.nih.gov/25919951
https://pubmed.ncbi.nlm.nih.gov/25919951
Autor:
Mark Pearson, Darryl B. McConnell, Laetitia J. Martin, Thomas Gerstberger, Yutaka Suzuki, Gerd Bader, Jae Seok Roe, Anja F. Hohmann, Junwei Shi, Christopher R. Vakoc, Manfred Koegl, Steffen Steurer, Teresa Gottschamel, Jessica L. Minder, Diane Thompson
Publikováno v:
Cancer Research. 76:LB-206
Recent studies have revealed vital roles of SWI/SNF complexes in leukemia and a variety of other cancers, making this chromatin remodeler a candidate drug target in human malignancy. Chemical modulation of SWI/SNF activity, however, remains to be ach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1e446bdc83c0be428e70e98f5670277
https://doi.org/10.1158/1538-7445.am2016-lb-206
https://doi.org/10.1158/1538-7445.am2016-lb-206
Autor:
Kamalan Jeevaratnam, Yanmin Zhang, Sarah M. Pearcey, Rudolf Duehmke, Anja F. Hohmann, Laila Guzadhur, Christopher L.-H. Huang, Andrew A. Grace, Ming Lei
Publikováno v:
Pflugers Archiv
Recent studies have reported that human mutations in Nav1.5 predispose to early age onset atrial arrhythmia. The present experiments accordingly assess atrial arrhythmogenicity in aging Scn5a+/KPQ mice modeling long QT3 syndrome in relationship to ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13e6cdf4de030903940c3d48f039035