Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells

Autor: Sabine Klawitter, Nina V. Fuchs, Kyle R. Upton, Martin Muñoz-Lopez, Ruchi Shukla, Jichang Wang, Marta Garcia-Cañadas, Cesar Lopez-Ruiz, Daniel J. Gerhardt, Attila Sebe, Ivana Grabundzija, Sylvia Merkert, Patricia Gerdes, J. Andres Pulgarin, Anja Bock, Ulrike Held, Anett Witthuhn, Alexandra Haase, Balázs Sarkadi, Johannes Löwer, Ernst J. Wolvetang, Ulrich Martin, Zoltán Ivics, Zsuzsanna Izsvák, Jose L. Garcia-Perez, Geoffrey J. Faulkner, Gerald G. Schumann

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)

Genetic and epigenetic abnormalities have been found to result from reprogramming of differentiated cells into human induced pluripotent stem cells (hiPSCs). Here, Klawitter et al.identify endogenous L1, Alu and SVA mobilization during reprogramming,

Externí odkaz: https://doaj.org/article/c3ef18eb5c21445d985ad18b9ff23d87

The Role of Beach and Wave Characteristics in Determining Suitable Habitat for Three Resident Shorebird Species in Tasmania

Autor: Eric J. Woehler, Anja Bock, Matthew R. Phillips

Publikováno v: Journal of Coastal Research. 75:358-362

Bock, A.; Phillips, M.R., and Woehler, E., 2016. The role of beach and wave characteristics in determining suitable habitat for three resident shorebird species in Tasmania. In: Vila-Concejo, A.; Bruce, E.; Kennedy, D.M., and McCarroll, R.J. (eds.),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::481f408dd361fb7f95186e583fb85d62
https://doi.org/10.2112/si75-072.1

Human LINE-1 restriction by APOBEC3C is deaminase independent and mediated by an ORF1p interaction that affects LINE reverse transcriptase activity

Autor: Jan-Hendrik Trösemeier, Axel V. Horn, Gerald G. Schumann, Robert A. Jabulowsky, Carsten Münk, Johannes Löwer, Kay-Martin Hanschmann, Henning Hofmann, André Berger, Sabine Klawitter, Anja Bock, Ananda Ayyappan Jaguva Vasudevan, Egbert Flory, Jeffrey S. Han, Roswitha Löwer, Ulrike Held

Publikováno v: Nucleic Acids Research

LINE-1 (L1) retrotransposons are mobile genetic elements whose extensive proliferation resulted in the generation of ≈ 34% of the human genome. They have been shown to be a cause of single-gene diseases. Moreover, L1-encoded endonuclease can elicit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6f44f06f408885c41f27329d8d305c
http://europepmc.org/articles/PMC3874205

The Engineered SVA Trans-mobilization Assay

Autor: Anja, Bock, Gerald G, Schumann

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1400

Mammalian genomes harbor autonomous retrotransposons coding for the proteins required for their own mobilization, and nonautonomous retrotransposons, such as the human SVA element, which are transcribed but do not have any coding capacity. Mobilizati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7e1d85c90e5c6bfd09b49ccdd1e881ef
https://pubmed.ncbi.nlm.nih.gov/26895056

Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells

Autor: Gerald G. Schumann, Zoltán Ivics, Marta García-Cañadas, Ulrike Held, Zsuzsanna Izsvák, Anett Witthuhn, Ruchi Shukla, Ernst J. Wolvetang, Daniel J. Gerhardt, Balázs Sarkadi, J. Andres Pulgarin, Johannes Löwer, Sabine Klawitter, Jose L. Garcia-Perez, Alexandra Haase, Ulrich Martin, Sylvia Merkert, Martin Muñoz-Lopez, Attila Sebe, Anja Bock, Ivana Grabundzija, Kyle R. Upton, Jichang Wang, Patricia Gerdes, Cesar Lopez-Ruiz, Nina V. Fuchs, Geoffrey J. Faulkner

Publikováno v: Nature Communications
Klawitter, S, Fuchs, N V, Upton, K R, Muñoz-Lopez, M, Shukla, R, Wang, J, Garcia-Cañadas, M, Lopez-Ruiz, C, Gerhardt, D J, Sebe, A, Grabundzija, I, Merkert, S, Gerdes, P, Pulgarin, J A, Bock, A, Held, U, Witthuhn, A, Haase, A, Sarkadi, B, Löwer, J, Wolvetang, E J, Martin, U, Ivics, Z, Izsvák, Z, Garcia-Perez, J L, Faulkner, G J & Schumann, G G 2016, ' Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells ', Nature Communications, vol. 7, pp. 10286 . https://doi.org/10.1038/ncomms10286
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)

Human induced pluripotent stem cells (hiPSCs) are capable of unlimited proliferation and can differentiate in vitro to generate derivatives of the three primary germ layers. Genetic and epigenetic abnormalities have been reported by Wissing and colle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fcc916635bdb9eef381a840be71aa5b
https://pubmed.ncbi.nlm.nih.gov/30568248