Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Anja Bathke"'
Publikováno v:
Methods and Protocols, Vol 7, Iss 5, p 71 (2024)
Polysorbates are the predominant surfactants used to stabilize protein formulations. Unfortunately, polysorbates can undergo hydrolytic degradation, which releases fatty acids that can accumulate to form visible particles. The detection and quantitat
Externí odkaz:
https://doaj.org/article/615abb47b5e249c0b99823afc6148d9f
Autor:
Feng Yang, Jennifer Zhang, Alexander Buettner, Eva Vosika, Monica Sadek, Zhiqi Hao, Dietmar Reusch, Maximiliane Koenig, Wayman Chan, Anja Bathke, Hilary Pallat, Victor Lundin, Jochen Felix Kepert, Patrick Bulau, Galahad Deperalta, Christopher Yu, Richard Beardsley, Tura Camilli, Reed Harris, John Stults
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTThe multi-attribute method (MAM), a liquid chromatography-mass spectrometry (LC-MS)-based peptide mapping method, has gained increased interest and applications in the biopharmaceutical industry. MAM can, in one method, provide targeted quant
Externí odkaz:
https://doaj.org/article/7874d2b0e1c34b02adff141b78f9fabe
Publikováno v:
Analytical Chemistry. 94:8136-8145
For the past few years, multidimensional liquid chromatography-mass spectrometry (LC-MS) systems have been commonly used to characterize post-translational modifications (PTMs) of therapeutic antibodies (mAbs). In most cases, this is performed by fra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e466dd3177e812849ac4cd656bffd6
https://doi.org/10.1021/acs.analchem.1c04450
https://doi.org/10.1021/acs.analchem.1c04450
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a58ba40544b16a84c7f80eb5a9cbfa
https://doi.org/10.2139/ssrn.4196746
https://doi.org/10.2139/ssrn.4196746
Autor:
Katrin Heinrich, Michael Leiss, Elena Domínguez-Vega, Sanne Pot, Christoph Gstöttner, Ingrid Grunert, Sina Hoelterhoff, Anja Bathke
Publikováno v:
Analytica Chimica Acta, 1184. ELSEVIER
Characterization of post-translational modifications (PTMs) of therapeutic antibodies is commonly performed by bottom-up approaches, involving sample preparation and peptide analysis by liquid chromatography-mass spectrometry (LC-MS). Conventional sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::248bb57008c67eee1d664e224ccb6f11
https://www.sciencedirect.com/science/article/pii/S0003267021008412?via=ihub
https://www.sciencedirect.com/science/article/pii/S0003267021008412?via=ihub
Autor:
Ingrid Grunert, Sina Hoelterhoff, Martin Winter, Thomas Weindl, Davy Guillarme, Saban Özipek, Cinzia Stella, Monika Meier, Katrin Heinrich, Julien Camperi, Anja Bathke, Patrick Bulau, Kilian Mayr, Michael Molhoj, Michael Leiss
Publikováno v:
Talanta, Vol. 234 (2021) P. 122628
An international study was conducted to evaluate the performance and reliability of an online multi-dimensional (mD)-LC-MS/MS approach for the characterization of antibody charge variants. The characterization of antibody charge variants is tradition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3caa353dd492ef0d46f2690965f9bffd
https://pubmed.ncbi.nlm.nih.gov/34364437
https://pubmed.ncbi.nlm.nih.gov/34364437
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1148
Monoclonal antibodies (mAbs) constitute one of the most important and fastest growing sector within the pharmaceutical industry. The variety of different formats and the large molecule sizes of the mAbs result in an inherent complexity. In addition,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82a5e9b958e713cf85af6e29ef7f5f4
https://pubmed.ncbi.nlm.nih.gov/32422530
https://pubmed.ncbi.nlm.nih.gov/32422530
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1116
Hydrolysis of the non-ionic surfactant polysorbate upon long-term storage poses significant challenges to development of biopharmaceutical liquid formulations. Low concentrations of intact surfactant may compromise its protective properties and thus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b2dfb61db600878ffeed4a4e6fbd60
https://pubmed.ncbi.nlm.nih.gov/30951966
https://pubmed.ncbi.nlm.nih.gov/30951966