Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Anja Balk"'
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 94:291-304
Ionic liquids (ILs) are organic salts with a melting point below 100°C. Active pharmaceutical ingredients (APIs) are transformed into ILs by combining them with typically large yet charged counterions. ILs hold promise to build a large design space
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0193d5c9dfebeb562fe0e65ed82ff96
https://doi.org/10.1016/j.ejpb.2015.05.027
https://doi.org/10.1016/j.ejpb.2015.05.027
Autor:
Franck Picard, Johannes Wiest, Marco Saedtler, Bruno Galli, Heike Bruhn, Anja Balk, Benjamin Merget, Christoph A. Sotriffer, Toni Widmer, Lorenz Meinel, Helga Stopper, Marc Raccuglia, Wolfgang Dekant, Elbast Walid, Tessa Lühmann, Ulrike Holzgrabe
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 268
Poor water solubility of drugs fuels complex formulations and jeopardizes patient access to medication. Simplifying these complexities we systematically synthesized a library of 36 sterically demanding counterions and mapped the pharmaceutical design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c50a5b7c52d4d8ed8957f0f3b216d3
https://pubmed.ncbi.nlm.nih.gov/29097303
https://pubmed.ncbi.nlm.nih.gov/29097303
Autor:
Toni Widmer, Klaus Müller-Buschbaum, Bruno Galli, Tessa Lühmann, Philipp R. Matthes, Jörg Berghausen, Anja Balk, Lorenz Meinel, Heike Bruhn, Ulrike Holzgrabe, Jens-Christoph Rybak, Anastasios Sakalis, Johannes Wiest
Publikováno v:
Pharmaceutical Research. 32:2154-2167
A poorly water soluble acidic active pharmaceutical ingredient (API) was transformed into an ionic liquid (IL) aiming at faster and higher oral availability in comparison to a prodrug.API preparations were characterized in solid state by single cryst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e40dcb4a1a4ab00e9b8f66fa37252dca
https://doi.org/10.1007/s11095-014-1607-9
https://doi.org/10.1007/s11095-014-1607-9
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 94
Poor water solubility of active pharmaceutical ingredients (API) is a major challenge in drug development impairing bioavailability and therapeutic benefit. This study is addressing the possibility to tailor pharmaceutical and physical properties of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2607d0c13e544d39474c8906f68e50bb
https://pubmed.ncbi.nlm.nih.gov/25976317
https://pubmed.ncbi.nlm.nih.gov/25976317