In vivo monitoring of leukemia-niche interactions in a zebrafish xenograft model.

Autor: Anja Arner, Andreas Ettinger, Bradley Wayne Blaser, Bettina Schmid, Irmela Jeremias, Nadia Rostam, Vera Binder-Blaser

Publikováno v: PLoS ONE, Vol 19, Iss 8, p e0309415 (2024)

Acute lymphoblastic leukemia (ALL) is the most common type of malignancy in children. ALL prognosis after initial diagnosis is generally good; however, patients suffering from relapse have a poor outcome. The tumor microenvironment is recognized as a

Externí odkaz: https://doaj.org/article/17ad6fb7b0134e96acfb19449f186da9

In vivo inducible reverse genetics in patients’ tumors to identify individual therapeutic targets

Autor: Kerstin Völse, Binje Vick, Wen-Hsin Liu, Daniela Senft, Lorenz Bastian, Denis M. Schewe, Marc Schmidt-Supprian, Vindi Jurinovic, Jan Philipp Schmid, Boris Fehse, Alexander Wilhelm, Martin Becker, Cornelius Miething, Kristoffer Riecken, Claudia D. Baldus, Johannes W. Bagnoli, Irmela Jeremias, Veronika Dill, Philipp J. Jost, Jenny Vergalli, Yuqiao Gao, Lennart Lenk, Anja Arner, Michela Carlet, Rolf Marschalek, Vera Binder, Tobias Herold

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications

High-throughput sequencing describes multiple alterations in individual tumors, but their functional relevance is often unclear. Clinic-close, individualized molecular model systems are required for functional validation and to identify therapeutic t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c108a41db88aecd0352ded6d797fe0a
https://doaj.org/article/6e797a213a574904a9cff02ded829844

Targeting actin inhibits repair of doxorubicin-induced {DNA} damage: {A} novel therapeutic approach for combination therapy

Autor: Lisa Pfitzer, Angelika M. Vollmar, Rebekka Kubisch-Dohmen, Rebecca Smith, Christina Moser, Themistoklis Zisis, Gyula Timinszky, Stefan Zahler, Olga V. Kalinina, Florian A. Gegenfurtner, Anja Arner, Johanna Busse, Ernst Wagner, Rolf Müller, Carina Atzberger, Florian Foerster

Publikováno v: Cell Death and Disease
Cell Death and Disease, Nature Publishing Group, 2019, 10 (4), pp.302. ⟨10.1038/s41419-019-1546-9⟩
Cell death & disease
Cell Death & Disease
Cell Death and Disease, Vol 10, Iss 4, Pp 1-14 (2019)
Cell Death and Disease, 2019, 10 (4), pp.302. ⟨10.1038/s41419-019-1546-9⟩

Severe side effects often restrict clinical application of the widely used chemotherapeutic drug doxorubicin. In order to decrease required substance concentrations, new concepts for successful combination therapy are needed. Since doxorubicin causes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fefd39517fd0521019e9c1bc9b0cc57
https://hal-univ-rennes1.archives-ouvertes.fr/hal-02119228/document