Top-Down Identification and Sequence Analysis of Small Membrane Proteins Using MALDI-MS/MS

Autor: Jakob Meier-Credo, Laura Preiss, Imke Wüllenweber, Anja Resemann, Christoph Nordmann, Jure Zabret, Detlev Suckau, Hartmut Michel, Marc M. Nowaczyk, Thomas Meier, Julian D. Langer

Publikováno v: Journal of the American Society for Mass Spectrometry. 33(7)

Identification and sequence determination by mass spectrometry have become routine analyses for soluble proteins. Membrane proteins, however, remain challenging targets due to their hydrophobicity and poor annotation. In particular small membrane pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40a981ab2ab8048ed164ed195c18b10
https://pubmed.ncbi.nlm.nih.gov/35758524

NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies

Autor: Miyako Nakano, Alena Wiegandt, Yunli Hu, Viv Lindo, Paulina A. Urbanowicz, Zsuzsanna Lakos, Cassie Caron, Song Klapoetke, Niels Christian Reichardt, Niclas Chiang Tan, Sandra Maier, Rene Hennig, Marton Szigeti, Ju Yeon Lee, Ying Qing Yu, Gregory O. Staples, Sachin Patil, Jolanta Jaworek, Waltraud Evers, Benjamin G. Kremkow, Youngsuk Seo, Kathirvel Alagesan, Yuetian Chen, Gordan Lauc, David L. Duewer, Yang Yang, Daniele Menard, Hyun Joo An, Tim Kelly, Stephen E. Stein, Joseph W. Leone, Anja Wiechmann, Ravi Amunugama, Peng George Wang, Clemens Grunwald-Grube, Maria Lorna A. De Leoz, Göran Larson, Rob Haselberg, Samanta Cajic, Stephanie A. Archer-Hartmann, Maja Pučić-Baković, Edward D. Bodnar, Pauline M. Rudd, Anja Resemann, Daniel Kolarich, Akira Harazono, Jeffrey S. Rohrer, Juan Echevarria Ruiz, Stuart Pengelley, Jong Shin Yoo, Arun V. Everest-Dass, Nicolle H. Packer, Steven W. Mast, William R. Alley, Erika Lattová, Anne Zeck, Corné J.M. Stroop, Radoslaw P. Kozak, Chun Shao, Alain Beck, Joseph Zaia, Erdmann Rapp, Lily Liu, Jennie Truong, Yaojun Wang, Christopher W. Cairo, Roisin O'Flaherty, Radka Saldova, Kudrat Goswami, Emy Komatsu, Jessica Örnros, Taiki Sugiyama, Prachi Bhoskar, Pralima Pradhan, Carlito B. Lebrilla, András Guttman, Christine Merle, Brian Kasper, Oscar G. Potter, Soo Kyung Suh, Li Phing Liew, Ranjan Chakrabarti, Terry D. Cyr, Sohei Funaoka, Masaaki Toyoda, Pui King Amy Leung, Toyin Kasali, Jerko Štambuk, Yanming An, Wolfgang Jabs, Bernd Meyer, Chunxia Zou, John F. Cipollo, Sa Rang Kim, Aaron Shafer, Randy M. Whittal, Jichao Kang, Albert J. R. Heck, Yehia Mechref, Hoi Kei Yau, Guinevere S. M. Lageveen-Kammeijer, Shiwei Sun, Kenichiro Furuki, Richard B. Jones, Béla Reiz, Niclas G. Karlsson, Mohammedazam Lahori, Xu Li, Barbara Adamczyk, Rui Cao, Lauren Wu, Koichi Kato, Detlev Suckau, Paweł Link-Lenczowski, Kelvin H. Lee, Xiaomin Song, Noortje de Haan, Ruth Frenkel, Adam Fung, Friedrich Altmann, Manfred Wuhrer, David Falck, Andreas Bock, Paula Magnelli, Brian Gau, Sachiko Kondo, Robert J. Emery, Chunsheng Jin, Louise Royle, David C. Muddiman, Hélène Perreault, John W. Froehlich, Disha Dadke, Peiqing Zhang, Lara K. Mahal, Takashi Nishikaze, Andrew Saati, Chuncui Huang, Hui Zhang, Carina Sihlbom, Parastoo Azadi, Jonas Nilsson, Yaming Liu, Yannis-Nicolas François, Nassur Said, Jin Young Kim, C. T. Yuen, Shuang Yang, Emmanuelle Leize-Wagner, David Harvey, Xiaofeng Shi, Yan Li, Hirokazu Yagi, Zoran Sosic, Elizabeth M. Hecht, Hua Yuan, Marybeth Creskey, Hyun Kyoung Lee, Sadanori Sekiya, Peter de Vreugd, Len Bell, Sam Tep

Publikováno v: De Leoz, M L A, Duewer, D L, Fung, A, Liu, L, Yau, H K, Potter, O, Staples, G O, Furuki, K, Frenkel, R, Hu, Y, Sosic, Z, Zhang, P, Altmann, F, Gru Nwald-Grube, C, Shao, C, Zaia, J, Evers, W, Pengelley, S, Suckau, D, Wiechmann, A, Resemann, A, Jabs, W, Beck, A, Froehlich, J W, Huang, C, Li, Y, Liu, Y, Sun, S, Wang, Y, Seo, Y, An, H J, Reichardt, N C, Ruiz, J E, Archer-Hartmann, S, Azadi, P, Bell, L, Lakos, Z, An, Y, Cipollo, J F, Pucic-Bakovic, M, Štambuk, J, Lauc, G, Li, X, Wang, P G, Bock, A, Hennig, R, Rapp, E, Creskey, M, Cyr, T D, Nakano, M, Sugiyama, T, Leung, P K A, Link-Lenczowski, P, Jaworek, J, Yang, S, Zhang, H, Kelly, T, Klapoetke, S, Cao, R, Kim, J Y, Lee, H K, Lee, J Y, Yoo, J S, Kim, S R, Suh, S K, de Haan, N, Falck, D, Lageveen-Kammeijer, G S M, Wuhrer, M, Emery, R J, Kozak, R P, Liew, L P, Royle, L, Urbanowicz, P A, Packer, N H, Song, X, Everest-Dass, A, Lattová, E, Cajic, S, Alagesan, K, Kolarich, D, Kasali, T, Lindo, V, Chen, Y, Goswami, K, Gau, B, Amunugama, R, Jones, R, Stroop, C J M, Kato, K, Yagi, H, Kondo, S, Yuen, C T, Harazono, A, Shi, X, Magnelli, P E, Kasper, B T, Mahal, L, Harvey, D J, O'Flaherty, R, Rudd, P M, Saldova, R, Hecht, E S, Muddiman, D C, Kang, J, Bhoskar, P, Menard, D, Saati, A, Merle, C, Mast, S, Tep, S, Truong, J, Nishikaze, T, Sekiya, S, Shafer, A, Funaoka, S, Toyoda, M, de Vreugd, P, Caron, C, Pradhan, P, Tan, N C, Mechref, Y, Patil, S, Rohrer, J S, Chakrabarti, R, Dadke, D, Lahori, M, Zou, C, Cairo, C, Reiz, B, Whittal, R M, Lebrilla, C B, Wu, L, Guttman, A, Szigeti, M, Kremkow, B G, Lee, K H, Sihlbom, C, Adamczyk, B, Jin, C, Karlsson, N G, Örnros, J, Larson, G, Nilsson, J, Meyer, B, Wiegandt, A, Komatsu, E, Perreault, H, Bodnar, E D, Said, N, Francois, Y N, Leize-Wagner, E, Maier, S, Zeck, A, Heck, A J R, Yang, Y, Haselberg, R, Yu, Y Q, Alley, W, Leone, J W, Yuan, H & Stein, S E 2020, ' NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies : Comparison of Results from Diverse Analytical Methods ', MCP : Molecular & cellular proteomics, vol. 19, no. 1, pp. 11-30 . https://doi.org/10.1074/mcp.RA119.001677
Molecular and Cellular Proteomics, 19(1), 11-30. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
MCP : Molecular & cellular proteomics, 19(1), 11-30. American Society for Biochemistry and Molecular Biology Inc.
Molecular & Cellular Proteomics
Molecular & Cellular Proteomics, 19(1), 11-30. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Molecular and Cellular Proteomics
Molecular and Cellular Proteomics, American Society for Biochemistry and Molecular Biology, 2019, mcp.RA119.001677. ⟨10.1074/mcp.RA119.001677⟩
Molecular and Cellular Proteomics, 19(1), 11. American Society for Biochemistry and Molecular Biology Inc.
Molecular & Cellular Proteomics : MCP

A broad-based interlaboratory study of glycosylation profiles of a reference and modified IgG antibody involving 103 reports from 76 laboratories.
Graphical Abstract Highlights A broad-based interlaboratory study of the glycosylation of a refere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4214e7f722323aeb909a6ec71f3d6bbd
https://doi.org/10.1074/mcp.RA119.001677

Use of PASEF for Accelerated Protein Sequence Confirmation and De Novo Sequencing with High Data Quality

Autor: Detlev, Suckau, Waltraud, Evers, Eckhard, Belau, Stuart, Pengelley, Anja, Resemann, Wilfred, Tang, K Ilker, Sen, Elsa, Wagner, Olivier, Colas, Alain, Beck

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2313

Biopharmaceutical sequences can be well confirmed by multiple protease digests-e.g., trypsin, elastase, and chymotrypsin-followed by LC-MS/MS data analysis. High quality data can be used for de novo sequencing as well. PASEF (Parallel Accumulation an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e6d3e4246f18e4c5a9a96810abdd1594
https://pubmed.ncbi.nlm.nih.gov/34478140

Interlaboratory study for characterizing monoclonal antibodies by top-down and middle-down mass spectrometry

Autor: Sam Hughes, Nicolas L. Young, David Clarke, Frank Sobott, Anja Resemann, Kristina Srzentić, Kim F. Haselmann, Detlev Suckau, Dina L. Bai, Young Ah Goo, Christian Malosse, Mathieu Dupré, Sylvester M. Greer, Neil R. Quebbemann, Ziqing Lin, Jared B. Shaw, Alain Beck, Yury O. Tsybin, Stuart Pengelley, Timothy K. Toby, Lidong He, Paul O. Danis, Henrique S. Seckler, Robert Anthony D’Ippolito, Natalia Gasilova, Jeffrey N. Agar, Donald F. Hunt, Jennifer S. Brodbelt, Matthew V. Holt, Simone Nicolardi, Joseph A. Loo, Yuri E. M. van der Burgt, Nicholas D. Schmitt, Laure Menin, Robert J. Millikin, Ljiljana Paša-Tolić, David R. Goodlett, Mowei Zhou, Joshua D. Hinkle, Michael R. Shortreed, Christopher L. Hendrickson, Wendy Sandoval, Richa Sarin, Jeffrey Shabanowitz, Alan G. Marshall, Anton N. Kozhinov, Neil L. Kelleher, Chad R. Weisbrod, Lissa C. Anderson, Julia Chamot-Rooke, Yunqiu Chen, John R. Yates, Luca Fornelli, Konstantin O. Nagornov, Lloyd M. Smith, Sneha Chatterjee, Ying Ge, Sung Hwan Yoon, Jolene K. Diedrich, Norelle C. Wildburger

Publikováno v: Journal of The American Society for Mass Spectrometry
Journal of The American Society for Mass Spectrometry, Springer Verlag (Germany), 2020, 31 (9), pp.1783-1802. ⟨10.1021/jasms.0c00036⟩
Journal of the American Society for Mass Spectrometry
Journal of the American Society for Mass Spectrometry, vol 31, iss 9
Journal of The American Society for Mass Spectrometry, 31(9), 1783-1802. AMER CHEMICAL SOC
J Am Soc Mass Spectrom
Journal of The American Society for Mass Spectrometry, 2020, 31 (9), pp.1783-1802. ⟨10.1021/jasms.0c00036⟩

International audience; The Consortium for Top-Down Proteomics (www.topdownproteomics.org) launched the present study to assess the current state of top-down mass spectrometry (TD MS) and middle-down mass spectrometry (MD MS) for characterizing monoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce93ac618ef03bef2381fe00d09bf9cf
https://hdl.handle.net/1887/3182316

Conformational μ-Conotoxin PIIIA Isomers Revisited: Impact of Cysteine Pairing on Disulfide-Bond Assignment and Structure Elucidation

Autor: Pascal Heimer, Alesia A. Tietze, Diana Imhof, Anja Resemann, Charlotte A. Bäuml, Daniel Tietze, Franz Josef Mayer, D. Suckau, Oliver Ohlenschläger

Publikováno v: Analytical chemistry. 90(5)

Peptides and proteins carrying high numbers of cysteines can adopt various 3D structures depending on their disulfide connectivities. The unambiguous verification of such conformational isomers with more than two disulfide bonds is extremely challeng

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7596ca3c26c7e6d624d513ce9048a66b
https://pubmed.ncbi.nlm.nih.gov/29397705