Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Anja, Gäckler"'
Autor:
Kristina Schönfelder, Lucas Kühne, Lena Schulte-Kemna, Jessica Kaufeld, Hana Rohn, Andreas Kribben, Bernd Schröppel, Paul T. Brinkkötter, Anja Gäckler
Publikováno v:
BMC Nephrology, Vol 25, Iss 1, Pp 1-8 (2024)
Abstract Background The complement factor 5 (C5)-inhibitor eculizumab has been established as standard-of-care for the treatment of atypical hemolytic uremic syndrome (aHUS). In 2021, the long-acting C5-inhibitor ravulizumab was approved, extending i
Externí odkaz:
https://doaj.org/article/064aa74fbb6e4cf0a385f7f62fede2f5
Autor:
Kristina Schönfelder, Birte Möhlendick, Ute Eisenberger, Andreas Kribben, Winfried Siffert, Falko M. Heinemann, Anja Gäckler, Benjamin Wilde, Justa Friebus-Kardash
Publikováno v:
Diagnostics, Vol 14, Iss 19, p 2202 (2024)
Background/Objectives: Our previous retrospective single-center cohort study found, at 3-year follow-up, a trend toward low tacrolimus trough levels and an increased risk of de novo donor-specific anti-HLA antibodies (DSAs) and of antibody-mediated r
Externí odkaz:
https://doaj.org/article/d93c3686f4fa4a33a24cacdf6a79f72e
Autor:
Edwin Wong, Carla Nester, Teresa Cavero, Alexandre Karras, Moglie Le Quintrec, Liz Lightstone, Ute Eisenberger, Maria Jose Soler, David Kavanagh, Erica Daina, Manuel Praga, Nicholas R. Medjeral-Thomas, Anja Gäckler, Clara Garcia-Carro, Andrea Biondani, Frederique Chaperon, Kenneth Kulmatycki, Julie Milojevic, Nicholas J.A. Webb, Prasanna Kumar Nidamarthy, Guido Junge, Giuseppe Remuzzi
Publikováno v:
Kidney International Reports, Vol 8, Iss 12, Pp 2754-2764 (2023)
Introduction: Complement 3 glomerulopathy (C3G) is a rare inflammatory kidney disease mediated by dysregulation of the alternative complement pathway. No targeted therapy exists for this aggressive glomerulonephritis. Efficacy, safety, tolerability,
Externí odkaz:
https://doaj.org/article/4142dfa19bbe4b318478e3240af7c53c
Autor:
Kristina Boss, Margarethe Konik, Jan Hinrich Bräsen, Jessica Schmitz, Christiane Jürgens, Andreas Kribben, Oliver Witzke, Sebastian Dolff, Anja Gäckler
Publikováno v:
BMC Nephrology, Vol 24, Iss 1, Pp 1-5 (2023)
Abstract Introduction Immunosuppressive therapy is associated with an increased risk of severe courses of SARS-CoV-2 infection, with frequently delayed viral clearance. We report a case of an acute kidney transplant failure in persistent SARS-CoV-2 i
Externí odkaz:
https://doaj.org/article/ae06ce3d1d5f45faa89be99c2f2c7bcf
Autor:
Laura Thümmler, Margarethe Konik, Monika Lindemann, Neslinur Fisenkci, Michael Koldehoff, Anja Gäckler, Peter A. Horn, Fotis Theodoropoulos, Christian Taube, Markus Zettler, Olympia Evdoxia Anastasiou, Peer Braß, Sarah Jansen, Oliver Witzke, Hana Rohn, Adalbert Krawczyk
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunocompromised patients are at increased risk for a severe course of COVID-19. Treatment of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection with anti-SARS-CoV-2 monoclonal antibodies (mAbs) has become widely accepted. Howeve
Externí odkaz:
https://doaj.org/article/960616c95cae4ed6b07d22684e10cfbd
Autor:
Anja Gäckler, Ulf Schönermarck, Vladimir Dobronravov, Gaetano La Manna, Andrew Denker, Peng Liu, Maria Vinogradova, Sung-Soo Yoon, Manuel Praga
Publikováno v:
BMC Nephrology, Vol 22, Iss 1, Pp 1-9 (2021)
Abstract Background Atypical hemolytic uremic syndrome (aHUS) triggered by pregnancy is a rare disease caused by dysregulation of the alternative complement pathway that occurs in approximately 1 in 25,000 pregnancies. The 311 phase 3 trial (NCT02949
Externí odkaz:
https://doaj.org/article/9339e685f80547318bdb36265bb477ae
Autor:
Hana Rohn, Cordula Lang, Sabine Schramm, Falko M. Heinemann, Mirko Trilling, Anja Gäckler, Oliver Witzke, Peter A. Horn, Vera Rebmann
Publikováno v:
Journal of Immunology Research, Vol 2022 (2022)
The human leukocyte antigen G (HLA-G) is an immune checkpoint molecule with a complex network of interactions with several inhibitory receptors. Although the effect of HLA-G on T cells and NK cells is well studied, the effect of HLA-G on B cells is s
Externí odkaz:
https://doaj.org/article/bc40e9f5db4146bba090e582ad7e2ec0
Autor:
Laura Thümmler, Monika Lindemann, Peter A. Horn, Veronika Lenz, Margarethe Konik, Anja Gäckler, Kristina Boss, Fotis Theodoropoulos, Vasiliki Besa, Christian Taube, Thorsten Brenner, Oliver Witzke, Adalbert Krawczyk, Hana Rohn
Publikováno v:
Viruses, Vol 15, Iss 1, p 119 (2022)
Vulnerable patients such as immunosuppressed or elderly patients are at high risk for a severe course of COVID-19 upon SARS-CoV-2 infection. Immunotherapy with SARS-CoV-2 specific monoclonal antibodies (mAb) or convalescent plasma represents a consid
Externí odkaz:
https://doaj.org/article/c61dcd6137864c6cbac2605228f22a20
Autor:
Anja Gäckler, Sebastian Dolff, Hana Rohn, Johannes Korth, Benjamin Wilde, Ute Eisenberger, Anna Mitchell, Andreas Kribben, Oliver Witzke
Publikováno v:
BMC Nephrology, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background The influence of pre- or postprandial administration on pharmacokinetics of cyclosporine is supposed to be less in gel-based formulations than in microemulsions. This study was designed to investigate the influence of a high-fat m
Externí odkaz:
https://doaj.org/article/1992e79fa9e7415fb79a45e588514042
Autor:
Laura Thümmler, Anja Gäckler, Maren Bormann, Sandra Ciesek, Marek Widera, Hana Rohn, Neslinur Fisenkci, Mona Otte, Mira Alt, Ulf Dittmer, Peter A. Horn, Oliver Witzke, Adalbert Krawczyk, Monika Lindemann
Publikováno v:
Vaccines, Vol 10, Iss 8, p 1348 (2022)
In kidney transplant (KTX) patients, immune responses after booster vaccination against SARS-CoV-2 are inadequately examined. We analyzed these patients a median of four months after a third/fourth vaccination and compared them to healthy controls. C
Externí odkaz:
https://doaj.org/article/d7842fb028ac43d3af732d8512336939