Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Anja, Deutzmann"'
Autor:
Anja Deutzmann, Delaney K. Sullivan, Renumathy Dhanasekaran, Wei Li, Xinyu Chen, Ling Tong, Wadie D. Mahauad-Fernandez, John Bell, Adriane Mosley, Angela N. Koehler, Yulin Li, Dean W. Felsher
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The MYC oncogene is often dysregulated in human cancer, including hepatocellular carcinoma (HCC). MYC is considered undruggable to date. Here, we comprehensively identify genes essential for survival of MYC high but not MYC low cells by a CR
Externí odkaz:
https://doaj.org/article/5d5960aaff2349adbf61a3465136928e
Autor:
Srividya Swaminathan, Aida S. Hansen, Line D. Heftdal, Renumathy Dhanasekaran, Anja Deutzmann, Wadie D. M. Fernandez, Daniel F. Liefwalker, Crista Horton, Adriane Mosley, Mariola Liebersbach, Holden T. Maecker, Dean W. Felsher
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Oncogene addiction is considered as a cancer cell-autonomous phenomenon, but can also influence the host immune system. Here the authors show that MYC-driven lymphomagenesis is associated with a block in the maturation and effector functions of natur
Externí odkaz:
https://doaj.org/article/e934ba6da0f2436b96b15ce1e0b4094b
Autor:
Delaney K. Sullivan, Anja Deutzmann, Josiah Yarbrough, Maya S. Krishnan, Arvin M. Gouw, David I. Bellovin, Stacey J. Adam, Daniel F. Liefwalker, Renumathy Dhanasekaran, Dean W. Felsher
Publikováno v:
Oncogene. 41:4960-4970
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3eb64b45b6309a74b1576bf01221b33
https://doi.org/10.1038/s41388-022-02458-9
https://doi.org/10.1038/s41388-022-02458-9
Autor:
Benjamin A. H. Smith, Anja Deutzmann, Kristina M. Correa, Corleone S. Delaveris, Renumathy Dhanasekaran, Christopher G. Dove, Delaney K. Sullivan, Simon Wisnovsky, Jessica C. Stark, John V. Pluvinage, Srividya Swaminathan, Nicholas M. Riley, Anand Rajan, Ravindra Majeti, Dean W. Felsher, Carolyn R. Bertozzi
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The Siglecs (sialic acid-binding immunoglobulin-like lectins) are glycoimmune checkpoint receptors that suppress immune cell activation upon engagement of cognate sialoglycan ligands. The cellular drivers underlying Siglec ligand production on cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2694bbb5db98e831f8954611f3dc713
https://doi.org/10.1073/pnas.2215376120
https://doi.org/10.1073/pnas.2215376120
Autor:
Arvin M. Gouw, Aida S. Hansen, Wadie D. Mahauad-Fernandez, Renumathy Dhanasekaran, Anja Deutzmann, Dean W. Felsher
Publikováno v:
Nat Rev Clin Oncol
The MYC proto-oncogenes encode a family of transcription factors that are among the most commonly activated oncoproteins in human neoplasias. Indeed, MYC aberrations or upregulation of MYC-related pathways by alternate mechanisms occur in the vast ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c504f9d46b9ee4b387d91f449159f6a
https://doi.org/10.1038/s41571-021-00549-2
https://doi.org/10.1038/s41571-021-00549-2
Publikováno v:
Hepatology
Spontaneous regression of cancer is rare and has been observed mostly in immunogenic cancers like melanoma. A few cases of spontaneous regression of hepatocellular carcinoma (HCC) have been reported, but the mechanisms of regression have not been elu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f1084fd9926fa589726ab9da02d420
https://doi.org/10.1002/hep.31489
https://doi.org/10.1002/hep.31489
Autor:
Delaney K, Sullivan, Anja, Deutzmann, Josiah, Yarbrough, Maya S, Krishnan, Arvin M, Gouw, David I, Bellovin, Stacey J, Adam, Daniel F, Liefwalker, Renumathy, Dhanasekaran, Dean W, Felsher
Publikováno v:
Oncogene. 41(45)
MYC is a transcription factor frequently overexpressed in cancer. To determine how MYC drives the neoplastic phenotype, we performed transcriptomic analysis using a panel of MYC-driven autochthonous transgenic mouse models. We found that MYC elicited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::03c37dfedb08a373b20abd5bb39a508b
https://pubmed.ncbi.nlm.nih.gov/36207533
https://pubmed.ncbi.nlm.nih.gov/36207533
Autor:
Daniel F. Liefwalker, Holden T. Maecker, Renumathy Dhanasekaran, Wadie D. M. Fernandez, Dean W. Felsher, Srividya Swaminathan, Line Dam Heftdal, Crista Horton, Anja Deutzmann, Mariola Liebersbach, Aida S. Hansen, Adriane Mosley
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The MYC oncogene drives T- and B- lymphoid malignancies, including Burkitt’s lymphoma (BL) and Acute Lymphoblastic Leukemia (ALL). Here, we demonstrate a systemic reduction in natural killer (NK) cell numbers in SRα-tTA/Tet-O-MYCON mice bearing MY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796bf03de0c068ffa924dd983f7549b1
https://doi.org/10.1038/s41467-020-16447-7
https://doi.org/10.1038/s41467-020-16447-7
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Accurate assessment of changes in cellular differentiation status in response to drug treatments or genetic perturbations is crucial for understanding tumorigenesis and developing novel therapeutics for human cancer. We have developed a novel computa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4bbbd256a594dc90992e96acfa2b29
https://doi.org/10.1038/s41598-019-53290-3
https://doi.org/10.1038/s41598-019-53290-3
Autor:
Anja Deutzmann, Renumathy Dhanasekaran, Daniel F. Liefwalker, Adriane Mosley, Srividya Swaminathan, Holden T. Maecker, Crista Horton, Dean W. Felsher, Line Dam Heftdal, Mariola Liebersbach
The MYC oncogene drives T and B lymphoid malignancies, including Burkitt’s lymphoma (BL) and Acute Lymphoblastic Leukemia (ALL). Using CyTOF, we demonstrate a systemic reduction in natural killer (NK) cell-mediated surveillance inSRα-tTA/Tet-O-MYC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83769fcc777ef23afc276c6d9ac9820f
https://doi.org/10.1101/503086
https://doi.org/10.1101/503086
