Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Anja, Bloom"'
Autor:
Katharine Clark, Jessica Yau, Anja Bloom, Jing Wang, David J. Venzon, Motoshi Suzuki, Lise Pasquet, Benjamin J. Compton, Susanna L. Cardell, Steven A. Porcelli, Gavin F. Painter, Dirk M. Zajonc, Jay A. Berzofsky, Masaki Terabe
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
iNKT cells are CD1d-restricted T cells recognizing lipid antigens. The prototypic iNKT cell-agonist α-galactosylceramide (α-GalCer) alongside compounds with similar structures induces robust proliferation and cytokine production of iNKT cells and p
Externí odkaz:
https://doaj.org/article/e95ec8af4f7c4721ac18347afdd733cc
Autor:
Andrew Godkin, Awen Gallimore, Tom Hockey, Adam Christian, Simon Phillips, Rachel Hargest, Mike Davies, Hayley Bridgeman, Kathryn Smart, Clare Brown, Rohit Srinivasan, Tom Pembroke, Anja Bloom, Martin Scurr
PDF file - 10925K, S. Fig. 1. Cultured 5T4-specific CD4+ T cells can be cloned from CRC patients (A) and healthy donors (B). S. Fig. 2. A comparison of 5T4 responses and age amongst CRC patients. S. Fig. 3. 5T4 Immunohistochemistry staining of frozen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e4fb6564364670e2df082f05d6e122
https://doi.org/10.1158/2326-6066.22536068.v1
https://doi.org/10.1158/2326-6066.22536068.v1
Autor:
Andrew Godkin, Awen Gallimore, Tom Hockey, Adam Christian, Simon Phillips, Rachel Hargest, Mike Davies, Hayley Bridgeman, Kathryn Smart, Clare Brown, Rohit Srinivasan, Tom Pembroke, Anja Bloom, Martin Scurr
The relationship between the adaptive CD4+ T-cell response and human cancer is unclear. The oncofetal antigen 5T4 is expressed in many human carcinomas, including colorectal cancer cells, but has limited expression on normal tissues. We previously id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b1bf0a7180aec6b54e1db4cf624551e
https://doi.org/10.1158/2326-6066.c.6548039.v1
https://doi.org/10.1158/2326-6066.c.6548039.v1
Autor:
Andrew Godkin, Awen Gallimore, Tom Hockey, Adam Christian, Simon Phillips, Rachel Hargest, Mike Davies, Hayley Bridgeman, Kathryn Smart, Clare Brown, Rohit Srinivasan, Tom Pembroke, Anja Bloom, Martin Scurr
PDF file - 65K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4188c8de9b64c796beb387924f72e320
https://doi.org/10.1158/2326-6066.22536071.v1
https://doi.org/10.1158/2326-6066.22536071.v1
Autor:
Andrew Godkin, Awen Gallimore, Robert Hills, Richard Harrop, Daniel Blount, Sarah Gwynne, Robert Jones, Alison Brewster, Richard Adams, Hayley Bridgeman, Kathryn Smart, Amanda Thomson, David Roberts, Anja Bloom, Tom Pembroke, Martin Scurr
Purpose: Anticancer T-cell responses can control tumors, but immunosuppressive mechanisms in vivo prevent their function. The role of regulatory T cells (Tregs) in metastatic colorectal cancer is unclear. We have previously shown depletion of Tregs e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d1f48485911346057d5a28de4595efc
https://doi.org/10.1158/1078-0432.c.6525245
https://doi.org/10.1158/1078-0432.c.6525245
Autor:
Andrew Godkin, Awen Gallimore, Robert Hills, Richard Harrop, Daniel Blount, Sarah Gwynne, Robert Jones, Alison Brewster, Richard Adams, Hayley Bridgeman, Kathryn Smart, Amanda Thomson, David Roberts, Anja Bloom, Tom Pembroke, Martin Scurr
Supplementary Figure 1. CONSORT diagram. Supplementary Figure 2. 5T4 peptide pools and matrix system. Supplementary Figure 3. B-cell number in response to cyclophosphamide. Supplementary Figure 4. Expression of activation markers in T-cell subsets du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ccf646f32661490d9797c502cb70e8a
https://doi.org/10.1158/1078-0432.22462886.v1
https://doi.org/10.1158/1078-0432.22462886.v1
Autor:
Masaki Terabe, Faith C. Robertson, Katharine Clark, Emma De Ravin, Anja Bloom, David J. Venzon, Shingo Kato, Amer Mirza, Jay A. Berzofsky
Publikováno v:
OncoImmunology, Vol 6, Iss 5 (2017)
Checkpoint inhibition has established immunotherapy as a major modality of cancer treatment. However, the success of cancer immunotherapy is still limited as immune regulation of tumor immunity is very complicated and mechanisms involved may also dif
Externí odkaz:
https://doaj.org/article/99f3560e21d741ceb59bff6e96c93455
Autor:
Andrew James Godkin, Andrew Blainey, Anja Bloom, Sarah Nicol Lauder, Jake Scott, Awen Gallimore, Emma Jones, Molly Browne, E. Hughes, Michelle Somerville, Ann Ager, Kathryn Smart
Publikováno v:
Cancer Immunology, Immunotherapy
Although metastatic disease is responsible for the majority of cancer deaths, tests of novel immunotherapies in mouse tumour models often focus on primary tumours without determining whether these therapies also target metastatic disease. This study
Autor:
Simon Phillips, Awen Gallimore, Martin J. Scurr, Tom Pembroke, Kathryn Smart, M. M. Davies, Andrew James Godkin, Clare M. Brown, Rohit Srinivasan, Tom Hockey, Hayley Bridgeman, Rachel Hargest, Adam Christian, Anja Bloom
Publikováno v:
Cancer Immunology Research. 1:416-425
The relationship between the adaptive CD4+ T-cell response and human cancer is unclear. The oncofetal antigen 5T4 is expressed in many human carcinomas, including colorectal cancer cells, but has limited expression on normal tissues. We previously id
Autor:
Ceri Alan Fielding, Sarah Nicol Lauder, Mathew Clement, Beatrice Ondondo, Philip R. Taylor, James P. Hindley, Kathryn Smart, Anja Bloom, Awen Gallimore, Anwen Sian Williams, Emma Jones, Simon Arnett Jones, Andrew James Godkin
Publikováno v:
European Journal of Immunology. 43:2613-2625
Balancing the generation of immune responses capable of controlling virus replication with those causing immunopathology is critical for the survival of the host and resolution of influenza-induced inflammation. Based on the capacity of interleukin-6