Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Anitha Suram"'
Autor:
Calvin B. Harley, Joseph M. Raffaele, Anitha Suram, Pratheesh Sudhakaran Sudhakaran, Gunasekaran Singaravelu
Publikováno v:
OBM Geriatrics. :1-1
TA-65 is a small molecule telomerase activator extracted from Astragalus species. A previous observational study suggested that TA-65 decreased the number of immunosenescent cells in healthy subjects. Here we examined the impact of TA-65 in a much la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2344a778328c86a4d0bd07b21c1d9b18
https://doi.org/10.21926/obm.geriatr.2102168
https://doi.org/10.21926/obm.geriatr.2102168
Autor:
Latha, Kallur Siddaramaiah, Anitha, Suram, Rao, Kosagi Sharaf Jagannatha *, Viswamitra, Mysore Ananthamurthy
Publikováno v:
In BBA - Molecular Basis of Disease 2002 1588(1):56-64
The replicometer is broken: telomeres activate cellular senescence in response to genotoxic stresses
Autor:
Anitha Suram, Utz Herbig
Publikováno v:
Aging Cell
Telomeres, the ends of our linear chromosomes, can function as ‘replicometers’, capable of counting cell division cycles as they progressively erode with every round of DNA replication. Once they are critically short, telomeres become dysfunction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22be4b66691aa8efc30e07844c206c60
https://doi.org/10.1111/acel.12246
https://doi.org/10.1111/acel.12246
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2016, 113 (34), pp.E5024-E5033. ⟨10.1073/pnas.1602379113⟩
Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (34), pp.E5024-E5033. ⟨10.1073/pnas.1602379113⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2016, 113 (34), pp.E5024-E5033. ⟨10.1073/pnas.1602379113⟩
Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (34), pp.E5024-E5033. ⟨10.1073/pnas.1602379113⟩
International audience; Oncogene-induced senescence (OIS) is a critical tumor-suppressing mechanism that restrains cancer progression at premalignant stages, in part by causing telomere dysfunction. Currently it is unknown whether this proliferative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7bff4f65dfdb6b36a5310902c71bd1f
https://hal-pasteur.archives-ouvertes.fr/pasteur-03234938/file/E5024.full.pdf
https://hal-pasteur.archives-ouvertes.fr/pasteur-03234938/file/E5024.full.pdf
Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions
Autor:
Resham L Gurung, Marzia Fumagalli, Anitha Suram, Utz Herbig, Fabrizio d'Adda di Fagagna, Raffaella Di Micco, Aurora Cerutti, Neena Mirani, Haihe Ruan, Priyanka L. Patel, Virginia Boccardi, Jessica Kaplunov, Manoor Prakash Hande
Publikováno v:
The EMBO Journal. 31:2839-2851
In normal human somatic cells, telomere dysfunction causes cellular senescence, a stable proliferative arrest with tumour suppressing properties. Whether telomere dysfunction-induced senescence (TDIS) suppresses cancer growth in humans, however, is u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9899fab78905f321fa23aa40f32228d0
https://doi.org/10.1038/emboj.2012.132
https://doi.org/10.1038/emboj.2012.132
Autor:
Chitra Venugopal, Yuan Su, Annamalai Prakasam, Steven M. Paul, Anitha Suram, Baolin Li, Kumar Sambamurti, Yan Zhou, Suizhen Lin
Publikováno v:
The FASEB Journal. 22:47-54
Cleavage of the amyloid precursor protein (APP) by β- and γ-secretases results in generation of the amyloid-β protein (Aβ), which is characteristically deposited in the brain of Alzheimer’s disease patients. Inhibitors of 3-hydroxy-3-methyl-glu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be020cdacc3dc2269fe15bde8f220020
https://doi.org/10.1096/fj.07-8175com
https://doi.org/10.1096/fj.07-8175com
Publikováno v:
Archives of Biochemistry and Biophysics. 463:245-252
Alzheimer's disease (AD) is a complex neurodegenerative disorder with a progressive mental deterioration manifested by memory loss. No definite etiology has been established for AD to date. Amyloid beta (Abeta) protein plays a central role in the pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f04c751d4a44712fbfc30e069948f21
https://doi.org/10.1016/j.abb.2007.03.015
https://doi.org/10.1016/j.abb.2007.03.015
Publikováno v:
Current Alzheimer Research. 3:365-375
Alzheimer's disease (AD) is a complex neurodegenerative disorder pathologically identified by the presence of extracellular senile plaques (SP) with a proteinaceous core composed of aggregates of the amyloid peptide (Abeta) and intracellular aggregat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec7c5a2134dd2af78c34753085dec9d
https://doi.org/10.2174/156720506778249380
https://doi.org/10.2174/156720506778249380
Autor:
Nigel H. Greig, Debomoy K. Lahiri, Kumar Sambamurti, Chitra Venugopal, Yan Zhou, Annamalai Prakasam, Anitha Suram
Publikováno v:
Current Alzheimer Research. 3:81-90
The amyloid hypothesis has dominated the thinking in our attempts to understand, diagnose and develop drugs for Alzheimer's disease (AD). This article presents a new hypothesis that takes into account the numerous familial AD (FAD) mutations in the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306d0ea352b0b2ee6eed81e937eef792
https://doi.org/10.2174/156720506775697142
https://doi.org/10.2174/156720506775697142
Autor:
Maria A. Blasco, Utz Herbig, Sophie Badie, Madalena Tarsounas, Maria Thanasoula, Peter Bouwman, Javier Benitez, Ana Rita Carlos, Jos Jonkers, Maria Mercedes Gallardo, Isabel Jaco, Anitha Suram, José M. Escandell
Publikováno v:
Nature Structural & Molecular Biology
Nature structural & molecular biology
Nature structural & molecular biology
The tumor suppressor protein BRCA2 is a key component of the homologous recombination pathway of DNA repair, acting as the loader of RAD51 recombinase at sites of double-strand breaks. Here we show that BRCA2 associates with telomeres during the S an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8b386695b4b9923e0e51fb6e82a5ab