Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Anita van Esch"'
Autor:
Alfred H. Schinkel, Olaf van Tellingen, Fan Lin, Martin van der Valk, Els Wagenaar, Evita van de Steeg, Anita van Esch, Ahmed Elbatsh, Marion Ludwig, Dilek Iusuf
PDF - 278KB, Supplemental figure 1. pH equilibrium between the lactone (closed ring) form and free carboxylic acid (open) form of irinotecan and SN-38. Supplemental Figure 2. Role of Oatp1a/1b uptake transporters in small intestinal (tissue plus cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638cae802c59446336feae0b2f280b61
https://doi.org/10.1158/1535-7163.22500156.v1
https://doi.org/10.1158/1535-7163.22500156.v1
Autor:
Alfred H. Schinkel, Olaf van Tellingen, Fan Lin, Martin van der Valk, Els Wagenaar, Evita van de Steeg, Anita van Esch, Ahmed Elbatsh, Marion Ludwig, Dilek Iusuf
Organic anion-transporting polypeptides (OATP) mediate the hepatic uptake of many drugs, thus codetermining their clearance. Impaired hepatic clearance due to low-activity polymorphisms in human OATP1B1 may increase systemic exposure to SN-38, the ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7919a874f439756c790a463f50f88691
https://doi.org/10.1158/1535-7163.c.6536373.v1
https://doi.org/10.1158/1535-7163.c.6536373.v1
Purpose: Organic anion-transporting polypeptide (OATP) drug uptake transporters are thought to play an important role in drug pharmacokinetics and toxicokinetics. We aimed to determine the influence of the individual human OATP1B1, OATP1B3, and OATP1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51395895b4130d22711ff2299ba77a1a
https://doi.org/10.1158/1078-0432.c.6521525.v1
https://doi.org/10.1158/1078-0432.c.6521525.v1
Autor:
Alfred H. Schinkel, Koen van de Wetering, Ronald P.J. Oude Elferink, Dirk R. de Waart, Olaf van Tellingen, Els Wagenaar, Anita van Esch, Zeliha Pala, Maria L.H. Vlaming
Supplementary Data from Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the In vivo Elimination of Methotrexate and its Main Toxic Metabolite 7-hydroxymethotrexate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f991808ad4b3b0de26cc12b4cccdbc
https://doi.org/10.1158/1078-0432.22439856
https://doi.org/10.1158/1078-0432.22439856
Autor:
Alfred H. Schinkel, Olaf van Tellingen, Koen van de Wetering, Els Wagenaar, Zeliha Pala, Anita van Esch, Maria L. H. Vlaming
Supplementary Table 3 from Abcc2 (Mrp2), Abcc3 (Mrp3), and Abcg2 (Bcrp1) are the main determinants for rapid elimination of methotrexate and its toxic metabolite 7-hydroxymethotrexate in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ffde04a5d0d12e54922271a7ffd34b
https://doi.org/10.1158/1535-7163.22484625.v1
https://doi.org/10.1158/1535-7163.22484625.v1
Autor:
Alfred H. Schinkel, Olaf van Tellingen, Koen van de Wetering, Els Wagenaar, Zeliha Pala, Anita van Esch, Maria L. H. Vlaming
Supplementary Table 1 from Abcc2 (Mrp2), Abcc3 (Mrp3), and Abcg2 (Bcrp1) are the main determinants for rapid elimination of methotrexate and its toxic metabolite 7-hydroxymethotrexate in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63abb7fcc0ec47eb4592e451ae16e247
https://doi.org/10.1158/1535-7163.22484631
https://doi.org/10.1158/1535-7163.22484631
PDF file - 86K,Descriptive RT-PCR data about the expression of other transporter proteins in livers of knockout and humanized transgenic OATP mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d17ed25334fceb43fcdde9a89c99d6
https://doi.org/10.1158/1078-0432.22448969.v1
https://doi.org/10.1158/1078-0432.22448969.v1
PDF file - 159K,Immunohistochemical staining of OATP1B3 in kidneys of humanized transgenic OATP1B3 mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b20bc46088199efa95d5ff78c689c5
https://doi.org/10.1158/1078-0432.22448975
https://doi.org/10.1158/1078-0432.22448975
Autor:
Alfred H. Schinkel, Olaf van Tellingen, Koen van de Wetering, Els Wagenaar, Zeliha Pala, Anita van Esch, Maria L. H. Vlaming
The multidrug transporters ABCC2, ABCC3, and ABCG2 can eliminate potentially toxic compounds from the body and have overlapping substrate specificities. To investigate the overlapping functions of Abcc2, Abcc3, and Abcg2 in vivo, we generated and cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79fe438cc05c2ee4a9774be10e220c57
https://doi.org/10.1158/1535-7163.c.6531498
https://doi.org/10.1158/1535-7163.c.6531498
PDF file - 101K, Tabular RT-PCR analysis results about the expression of other transporter proteins in livers of knockout and humanized transgenic OATP mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1868653c2e62b3230002ed32597dfc28
https://doi.org/10.1158/1078-0432.22448966.v1
https://doi.org/10.1158/1078-0432.22448966.v1