Výsledky vyhledávání - "Anita T. Shortnacy"

Synthesis and Anticancer Evaluation of 4′-C-Methyl-2′-Fluoro Arabino Nucleosides

Autor: William R. Waud, John A. Secrist, William B. Parker, Kamal N. Tiwari, Anita T. Shortnacy-Fowler

Publikováno v: Nucleosides, Nucleotides & Nucleic Acids. 28:657-677

As part of an ongoing program to develop novel antitumor agents over the years, we have synthesized and evaluated a number of 4'-C-substituted nucleosides. A few years ago, we reported the first synthesis of 4'-C-hydroxymethyl-2'-fluoro arabino nucle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae1b21eae8e5fbde3fe1db238256693
https://doi.org/10.1080/15257770903091946

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Synthesis and Structure Activity Relationships of 5-Substituted - 4′-thio-β-D-Arabinofuranosylcytosines

Autor: William B. Parker, Loredana Cappellacci, Kamal N. Tiwari, William R. Waud, John A. Secrist, Anita T. Shortnacy-Fowler, John A. Montgomery

Publikováno v: Nucleosides, Nucleotides and Nucleic Acids. 19:2005-2017

Four 5-substituted (chloro, fluoro, bromo, methyl) 1-(4-thio-beta-D-arabinofuranosyl)cytosines and their alpha anomers were synthesized by a facile route in high yields. All of these nucleosides were evaluated for cytotoxicity against a panel of huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd65b4a1b836bd5f5206875676ba9251
https://doi.org/10.1080/15257770008045474

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Synthesis of 4′-Thio-β-D-arabinofuranosylcytosine (4′-Thio-ara-C) and Comparison of Its Anticancer Activity with That of Ara-C

Autor: William B. Parker, John A. Secrist, Kamal N. Tiwari, Loredana Cappellacci, John A. Montgomery, William R. Waud, Anita T. Shortnacy-Fowler

Publikováno v: Nucleosides, Nucleotides and Nucleic Acids. 19:329-340

4'-thio-beta-D-arabinofuranosylcytosine was synthesized by a facile route in high yields. It was evaluated for antitumor activity against a panel of human tumors, both in vitro and in vivo.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f8b76b331e86968ef0f4e03c04880d
https://doi.org/10.1080/15257770008033012

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Synthesis and Biological Activity of 2′-Fluoro-D-arabinofuranosylpyrazolo[3,4-d]pyrimidine Nucleosides

Autor: Kamal N. Tiwari, John A. Secrist, Robert W. Buckheit, John A. Montgomery, Anita T. Shortnacy-Fowler, Frank Seela

Publikováno v: Helvetica Chimica Acta. 82:2240-2245

Coupling of 2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl bromide with 4-methoxypyrazolo[3,4-d]pyrimidine gave an α-D/β-D mixture of N1- and N2-coupled products. All the anomers were separated and deblocked to yield the corresponding nucleosides.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5488191bbb880e5a47c9b3abbb8f52a
https://doi.org/10.1002/(sici)1522-2675(19991215)82:12<2240::aid-hlca2240>3.0.co

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Synthesis and Biological Activity of Certain 4‘-Thio-d-arabinofuranosylpurine Nucleosides

Autor: John A. Montgomery, Kamal N. Tiwari, Anita T. Shortnacy-Fowler, Lea Messini, John A. Secrist, James M. Riordan, Scott C. Meyers, Steven E. Ealick

Publikováno v: Journal of Medicinal Chemistry. 41:3865-3871

A series of 4'-thio-D-arabinofuranosylpurine nucleosides was prepared and evaluated as potential anticancer agents. The details of a convenient and high-yielding synthesis of the carbohydrate precursor 1-O-acetyl-2,3,5-tri-O-benzyl-4-thio-D-arabinofu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ece82a59af8e0e703c83a77c5c5e329f
https://doi.org/10.1021/jm980195+

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Synthesis and Antiviral Evaluation of Analogs of Adenosine-N1-Oxide and 1-(Benzyloxy)Adenosine

Autor: Charles A. Krauth, Anita T. Shortnacy-Fowler, John A. Secrist, G. Arnett, John A. Montgomery, Cecil D. Kwong, William M. Shannon, Melinda G. Hollingshead

Publikováno v: Nucleosides and Nucleotides. 17:1409-1443

The activity of a series of compounds related to adenosine-N 1-oxide (1) and 1-(benzyloxy)adenosine (42) against vaccinia virus has been determined both in vitro and in a vaccinia mouse tailpox model. Significant activities have been found both in vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f411a59185fe8fa77ecdfc895acc2cc6
https://doi.org/10.1080/07328319808003478

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Synthesis and Biologic Evaluation of 8-Substituted Derivatives of Nebularine (9-β-D-Ribofuranosylpurine)

Autor: John A. Montgomery, Anita T. Shortnacy-Fowler, L. Lee Bennett, John A. Secrist

Publikováno v: Nucleosides and Nucleotides. 13:1017-1029

A series of 8-substituted purine ribonucleosides were prepared from 2′, 3′, 5′-tri-O-acetyl-8-bromoadenosine and evaluated for cytotoxicity and antiviral activity. Four of these nucleosides (6b-9b) were significantly toxic to both HEp-2 and L12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c21da66c050ae587a584ee84e9d8d0da
https://doi.org/10.1080/15257779408011875

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