Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Anita Sveen"'
Autor:
Jonas Langerud, Ina A. Eilertsen, Seyed H. Moosavi, Solveig M. K. Klokkerud, Henrik M. Reims, Ingeborg F. Backe, Merete Hektoen, Ole H. Sjo, Marine Jeanmougin, Sabine Tejpar, Arild Nesbakken, Ragnhild A. Lothe, Anita Sveen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Intra-tumor heterogeneity compromises the clinical value of transcriptomic classifications of colorectal cancer. We investigated the prognostic effect of transcriptomic heterogeneity and the potential for classifications less vulnerable to h
Externí odkaz:
https://doaj.org/article/d4d1453bbc3e48efb2d29292fe31b570
Autor:
Maren Høland, Kaja C.G. Berg, Ina A. Eilertsen, Bodil Bjerkehagen, Matthias Kolberg, Kjetil Boye, Ole Christian Lingjærde, Tormod K. Guren, Nils Mandahl, Eva van den Berg, Emanuela Palmerini, Sigbjørn Smeland, Piero Picci, Fredrik Mertens, Anita Sveen, Ragnhild A. Lothe
Publikováno v:
EBioMedicine, Vol 97, Iss , Pp 104829- (2023)
Summary: Background: Malignant peripheral nerve sheath tumour (MPNST) is an aggressive orphan disease commonly affecting adolescents or young adults. Current knowledge of molecular tumour biology has been insufficient for development of rational trea
Externí odkaz:
https://doaj.org/article/120a8ea2f5d04915b737b8e0d970bebb
Autor:
Seyed H. Moosavi, Peter W. Eide, Ina A. Eilertsen, Tuva H. Brunsell, Kaja C. G. Berg, Bård I. Røsok, Kristoffer W. Brudvik, Bjørn A. Bjørnbeth, Marianne G. Guren, Arild Nesbakken, Ragnhild A. Lothe, Anita Sveen
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-19 (2021)
Abstract Background Gene expression-based subtyping has the potential to form a new paradigm for stratified treatment of colorectal cancer. However, current frameworks are based on the transcriptomic profiles of primary tumors, and metastatic heterog
Externí odkaz:
https://doaj.org/article/b1393ac416664e709cf7f9292e056fff
Autor:
Anita Sveen, Bjarne Johannessen, Ina A. Eilertsen, Bård I. Røsok, Marie Gulla, Peter W. Eide, Jarle Bruun, Kushtrim Kryeziu, Leonardo A. Meza-Zepeda, Ola Myklebost, Bjørn A. Bjørnbeth, Rolf I. Skotheim, Arild Nesbakken, Ragnhild A. Lothe
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-18 (2021)
Abstract Background Colorectal cancer is the 2nd leading cause of cancer-related deaths with few patients benefiting from biomarker-guided therapy. Mutation expression is essential for accurate interpretation of mutations as biomarkers, but surprisin
Externí odkaz:
https://doaj.org/article/b34b58a9f5234132b5b1362c2f2bb886
Autor:
Kushtrim Kryeziu, Seyed H. Moosavi, Christian H. Bergsland, Marianne G. Guren, Peter W. Eide, Max Z. Totland, Kristoffer Lassen, Andreas Abildgaard, Arild Nesbakken, Anita Sveen, Ragnhild A. Lothe
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-11 (2021)
Abstract Tumor heterogeneity is a primary cause of treatment failure. However, changes in drug sensitivity over time are not well mapped in cancer. Patient-derived organoids (PDOs) may predict clinical drug responses ex vivo and offer an opportunity
Externí odkaz:
https://doaj.org/article/ae8e4589a2914bc0acf2c8d31711cf45
Autor:
Peter W. Eide, Seyed H. Moosavi, Ina A. Eilertsen, Tuva H. Brunsell, Jonas Langerud, Kaja C. G. Berg, Bård I. Røsok, Bjørn A. Bjørnbeth, Arild Nesbakken, Ragnhild A. Lothe, Anita Sveen
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-9 (2021)
Abstract Gene expression-based subtypes of colorectal cancer have clinical relevance, but the representativeness of primary tumors and the consensus molecular subtypes (CMS) for metastatic cancers is not well known. We investigated the metastatic het
Externí odkaz:
https://doaj.org/article/8094865baf5d4bffb26a44258515a35d
Autor:
Kaja C. G. Berg, Tuva H. Brunsell, Anita Sveen, Sharmini Alagaratnam, Merete Bjørnslett, Merete Hektoen, Kristoffer W. Brudvik, Bård I. Røsok, Bjørn Atle Bjørnbeth, Arild Nesbakken, Ragnhild A. Lothe
Publikováno v:
Molecular Oncology, Vol 15, Iss 4, Pp 830-845 (2021)
Hepatic resection is potentially curative for patients with colorectal liver metastases, but the treatment benefit varies. KRAS/NRAS (RAS)/TP53 co‐mutations are associated with a poor prognosis after resection, but there is large variation in patie
Externí odkaz:
https://doaj.org/article/d2dbfb57bdf24a8294717b68cf6264b2
Autor:
Marine Jeanmougin, Annette B. Håvik, Lina Cekaite, Petter Brandal, Anita Sveen, Torstein R. Meling, Trude H. Ågesen, David Scheie, Sverre Heim, Ragnhild A. Lothe, Guro E. Lind
Publikováno v:
Molecular Oncology, Vol 14, Iss 5, Pp 1016-1027 (2020)
Glioblastoma (GBM), the most aggressive form of brain cancer, is characterized by a high level of molecular heterogeneity, and infiltration by various immune and stromal cell populations. Important advances have been made in deciphering the microenvi
Externí odkaz:
https://doaj.org/article/50f176e97628490093af05af0a6840dd
Autor:
Jarle Bruun, Anita Sveen, Rita Barros, Peter W. Eide, Ina Eilertsen, Matthias Kolberg, Teijo Pellinen, Leonor David, Aud Svindland, Olli Kallioniemi, Marianne G. Guren, Arild Nesbakken, Raquel Almeida, Ragnhild A. Lothe
Publikováno v:
Molecular Oncology, Vol 12, Iss 9, Pp 1639-1655 (2018)
We aimed to refine the value of CDX2 as an independent prognostic and predictive biomarker in colorectal cancer (CRC) according to disease stage and chemotherapy sensitivity in preclinical models. CDX2 expression was evaluated in 1045 stage I–IV pr
Externí odkaz:
https://doaj.org/article/86ace7d506a24870a91ce2572c977013
Autor:
Jørgen Smeby, Kushtrim Kryeziu, Kaja C.G. Berg, Ina A. Eilertsen, Peter W. Eide, Bjarne Johannessen, Marianne G. Guren, Arild Nesbakken, Jarle Bruun, Ragnhild A. Lothe, Anita Sveen
Publikováno v:
EBioMedicine, Vol 59, Iss , Pp 102923- (2020)
Background: PARP inhibitors are active in various tumour types beyond BRCA-mutant cancers, but their activity and molecular correlates in colorectal cancer (CRC) are not well studied. Methods: Mutations and genome-wide mutational patterns associated
Externí odkaz:
https://doaj.org/article/aa799509497e47aca84342bd1349c228