Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Anita Pottekat"'
Autor:
Zhouji Chen, Shiyu Wang, Anita Pottekat, Alec Duffey, Insook Jang, Benny H. Chang, Jaehyung Cho, Brian N. Finck, Nicholas O. Davidson, Randal J. Kaufman
Publikováno v:
Molecular Metabolism, Vol 80, Iss , Pp 101874- (2024)
Objectives: The assembly and secretion of hepatic very low-density lipoprotein (VLDL) plays pivotal roles in hepatic and plasma lipid homeostasis. Protein disulfide isomerase A1 (PDIA1/P4HB) is a molecular chaperone whose functions are essential for
Externí odkaz:
https://doaj.org/article/2eb00029f7a54fa383e62a065aa4cf9b
Autor:
Anoop Arunagiri, Leena Haataja, Anita Pottekat, Fawnnie Pamenan, Soohyun Kim, Lori M Zeltser, Adrienne W Paton, James C Paton, Billy Tsai, Pamela Itkin-Ansari, Randal J Kaufman, Ming Liu, Peter Arvan
Publikováno v:
eLife, Vol 8 (2019)
Biosynthesis of insulin – critical to metabolic homeostasis – begins with folding of the proinsulin precursor, including formation of three evolutionarily conserved intramolecular disulfide bonds. Remarkably, normal pancreatic islets contain a su
Externí odkaz:
https://doaj.org/article/e7a8653824104c16932bbe4cb7da543b
Autor:
Insook Jang, Anita Pottekat, Juthakorn Poothong, Jing Yong, Jacqueline Lagunas-Acosta, Adriana Charbono, Zhouji Chen, Donalyn L Scheuner, Ming Liu, Pamela Itkin-Ansari, Peter Arvan, Randal J Kaufman
Publikováno v:
eLife, Vol 8 (2019)
Regulated proinsulin biosynthesis, disulfide bond formation and ER redox homeostasis are essential to prevent Type two diabetes. In ß cells, protein disulfide isomerase A1 (PDIA1/P4HB), the most abundant ER oxidoreductase of over 17 members, can int
Externí odkaz:
https://doaj.org/article/606748e9851d4069a19e7e64c04c8f22
Insulin Biosynthetic Interaction Network Component, TMEM24, Facilitates Insulin Reserve Pool Release
Autor:
Anita Pottekat, Scott Becker, Kathryn R. Spencer, John R. Yates, III, Gerard Manning, Pamela Itkin-Ansari, William E. Balch
Publikováno v:
Cell Reports, Vol 4, Iss 5, Pp 921-930 (2013)
Insulin homeostasis in pancreatic β cells is now recognized as a critical element in the progression of obesity and type II diabetes (T2D). Proteins that interact with insulin to direct its sequential synthesis, folding, trafficking, and packaging i
Externí odkaz:
https://doaj.org/article/00e3f3761be044b295b2fca4466d8629
Autor:
Duc T Tran, Anita Pottekat, Kouta Lee, Megha Raghunathan, Salvatore Loguercio, Saiful A Mir, Adrienne W Paton, James C Paton, Peter Arvan, Randal J Kaufman, Pamela Itkin-Ansari
Publikováno v:
J Clin Endocrinol Metab
Context Aberrant biosynthesis and secretion of the insulin precursor proinsulin occurs in both type I and type II diabetes. Inflammatory cytokines are implicated in pancreatic islet stress and dysfunction in both forms of diabetes, but the mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dafe875f3c854610097ee122a7d75e37
https://europepmc.org/articles/PMC10233482/
https://europepmc.org/articles/PMC10233482/
Autor:
Pamela Itkin-Ansari, Randal J. Kaufman, William E. Balch, Peter Arvan, Ming Liu, Reyhaneh Lahmy, Kathleen M. Scully, Alexandre Rosa Campos, Insook Jang, Salvatore Loguercio, Saiful A. Mir, Anita Pottekat, Duc T. Tran, Ada Admin
The beta cell protein synthetic machinery is dedicated to the production of mature insulin, which requires the proper folding and trafficking of its precursor, proinsulin. The complete network of proteins that mediate proinsulin folding and advanceme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::031d6628f27e281d1887218978b6a65f
https://doi.org/10.2337/figshare.12311435.v1
https://doi.org/10.2337/figshare.12311435.v1
Autor:
Peter Arvan, Alexandre Rosa Campos, Insook Jang, Pamela Itkin-Ansari, Salvatore Loguercio, Reyhaneh Lahmy, William E. Balch, Saiful A. Mir, Kathleen M. Scully, Anita Pottekat, Ming Liu, Duc T. Tran, Randal J. Kaufman
Publikováno v:
Diabetes
The β-cell protein synthetic machinery is dedicated to the production of mature insulin, which requires the proper folding and trafficking of its precursor, proinsulin. The complete network of proteins that mediate proinsulin folding and advancement
Autor:
Anita Pottekat, Mark F. Swift, Zhouji Chen, Niels Volkmann, Juthakorn Poothong, Marina Siirin, Jacqueline Lagunas-Acosta, James C. Paton, Dorit Hanein, Jing Yong, Adrienne W. Paton, Alexandre Rosa Campos, Randal J. Kaufman
Factor VIII (FVIII) is the coagulation factor deficient in hemophilia A, which is treated by protein replacement. Unfortunately, this regimen is costly due to the expense of producing recombinant FVIII as a consequence of its low level secretion. FVI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d79fdc3122cb4401534831cabb9273
Autor:
Saiful A. Mir, Anita Pottekat, Pamela Itkin-Ansari, Reyhaneh Lahmy, Alexandre Rosa Campos, William E. Balch, Peter Arvan, Duc T. Tran, Ming Liu, Salvatore Loguercio, Insook Jang, Randal J. Kaufman
The beta-cell protein synthetic machinery is dedicated to the production of insulin, which plays a critical role in organismal homeostasis. Insulin synthesis requires the proper folding and trafficking of its precursor, proinsulin, yet the precise ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4ba4db3658b2c10c279055a3d0cc33c
Autor:
Jing Yong, Peter Arvan, Ming Liu, Juthakorn Poothong, Insook Jang, Adriana Charbono, Jacqueline Lagunas-Acosta, Randal J. Kaufman, Zhouji Chen, Pamela Itkin-Ansari, Anita Pottekat, Donalyn L Scheuner
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
Regulated proinsulin biosynthesis, disulfide bond formation and ER redox homeostasis are essential to prevent Type two diabetes. In ß cells, protein disulfide isomerase A1 (PDIA1/P4HB), the most abundant ER oxidoreductase of over 17 members, can int