Cyclodextrin Derivatives as Promising Solubilizers to Enhance the Biological Activity of Rosmarinic Acid

Autor: Anna Stasiłowicz-Krzemień, Natalia Rosiak, Anita Płazińska, Wojciech Płaziński, Andrzej Miklaszewski, Ewa Tykarska, Judyta Cielecka-Piontek

Publikováno v: Pharmaceutics, Vol 14, Iss 10, p 2098 (2022)

Rosmarinic acid (RA) is a natural antioxidant with neuroprotective properties; however, its preventive and therapeutic use is limited due to its slight solubility and poor permeability. This study aimed to improve RA physicochemical properties by sys

Externí odkaz: https://doaj.org/article/18e7408d026a44ddb8b1503a48e6e1f8

Identification of the first-in-class dual inhibitors of human DNA topoisomerase IIα and indoleamine-2,3-dioxygenase 1 (IDO 1) with strong anticancer properties

Autor: Barbara Kaproń, Anita Płazińska, Wojciech Płaziński, Tomasz Plech

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry. 38:192-202

Molecular docking of a large set of thiosemicarbazide-based ligands resulted in obtaining compounds that inhibited both human DNA topoisomerase IIα and indoleamine-2,3-dioxygenase-1 (IDO1). To the best of our knowledge, these compounds are the first

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343cc9bfbe4cc071fc96e4ce75f29729
https://doi.org/10.1080/14756366.2022.2140420

Synthesis of Novel 2-(Cyclopentylamino)thiazol-4(5H)-one Derivatives with Potential Anticancer, Antioxidant, and 11β-HSD Inhibitory Activities

Autor: Szymon Baumgart, Daria Kupczyk, Aneta Archała, Oliwia Koszła, Przemysław Sołek, Wojciech Płaziński, Anita Płazińska, Renata Studzińska

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 8; Pages: 7252

In this study, a series of nine new 2-(cyclopentylamino)thiazol-4(5H)-one derivatives were synthesized, and their anticancer, antioxidant, and 11β-hydroxysteroid dehydrogenase (11β-HSD) inhibitory activities were tested. Anticancer activity has bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6505746481be0c590a0d9a1d4bf333
https://doi.org/10.3390/ijms24087252

The Systems of Naringenin with Solubilizers Expand Its Capability to Prevent Neurodegenerative Diseases

Autor: Anna Stasiłowicz-Krzemień, Michał Gołębiewski, Anita Płazińska, Wojciech Płaziński, Andrzej Miklaszewski, Marcin Żarowski, Zofia Adamska-Jernaś, Judyta Cielecka-Piontek

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 2; Pages: 755
International Journal of Molecular Sciences, Vol 23, Iss 755, p 755 (2022)
International Journal of Molecular Sciences

Background: Naringenin (NAR) is a flavonoid with excellent antioxidant and neuroprotective potential that is limited by its low solubility. Thus, solid dispersions with β-cyclodextrin (β-CD), hydroxypropyl-β-cyclodextrin (HP-β-CD), hydroxypropylm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0feb50db12fa1a433c1ad40472a387e9

Ketamine Metabolites Enantioselectively Decrease Intracellular D-Serine Concentrations in PC-12 Cells.

Autor: Nagendra S Singh, Ewelina Rutkowska, Anita Plazinska, Mohammed Khadeer, Ruin Moaddel, Krzysztof Jozwiak, Michel Bernier, Irving W Wainer

Publikováno v: PLoS ONE, Vol 11, Iss 4, p e0149499 (2016)

D-Serine is an endogenous NMDA receptor co-agonist that activates synaptic NMDA receptors modulating neuronal networks in the cerebral cortex and plays a key role in long-term potentiation of synaptic transmission. D-serine is associated with NMDA re

Externí odkaz: https://doaj.org/article/0a036b345b984abebf3eeaae410b8ff9