Cyclodextrin Derivatives as Promising Solubilizers to Enhance the Biological Activity of Rosmarinic Acid

Autor: Anna Stasiłowicz-Krzemień, Natalia Rosiak, Anita Płazińska, Wojciech Płaziński, Andrzej Miklaszewski, Ewa Tykarska, Judyta Cielecka-Piontek

Publikováno v: Pharmaceutics, Vol 14, Iss 10, p 2098 (2022)

Rosmarinic acid (RA) is a natural antioxidant with neuroprotective properties; however, its preventive and therapeutic use is limited due to its slight solubility and poor permeability. This study aimed to improve RA physicochemical properties by sys

Externí odkaz: https://doaj.org/article/18e7408d026a44ddb8b1503a48e6e1f8

Structural Insights into Ligand—Receptor Interactions Involved in Biased Agonism of G-Protein Coupled Receptors

Autor: Krzysztof Jóźwiak, Anita Płazińska

Publikováno v: Molecules, Vol 26, Iss 4, p 851 (2021)

G protein-coupled receptors (GPCRs) are versatile signaling proteins that mediate complex cellular responses to hormones and neurotransmitters. Ligand directed signaling is observed when agonists, upon binding to the same receptor, trigger significan

Externí odkaz: https://doaj.org/article/8a2f46d467b147f5a4d5d3c7003ea5bb

Synthesis of Novel 2-(Cyclopentylamino)thiazol-4(5H)-one Derivatives with Potential Anticancer, Antioxidant, and 11β-HSD Inhibitory Activities

Autor: Szymon Baumgart, Daria Kupczyk, Aneta Archała, Oliwia Koszła, Przemysław Sołek, Wojciech Płaziński, Anita Płazińska, Renata Studzińska

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 8; Pages: 7252

In this study, a series of nine new 2-(cyclopentylamino)thiazol-4(5H)-one derivatives were synthesized, and their anticancer, antioxidant, and 11β-hydroxysteroid dehydrogenase (11β-HSD) inhibitory activities were tested. Anticancer activity has bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6505746481be0c590a0d9a1d4bf333
https://doi.org/10.3390/ijms24087252

The Systems of Naringenin with Solubilizers Expand Its Capability to Prevent Neurodegenerative Diseases

Autor: Anna Stasiłowicz-Krzemień, Michał Gołębiewski, Anita Płazińska, Wojciech Płaziński, Andrzej Miklaszewski, Marcin Żarowski, Zofia Adamska-Jernaś, Judyta Cielecka-Piontek

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 2; Pages: 755
International Journal of Molecular Sciences, Vol 23, Iss 755, p 755 (2022)
International Journal of Molecular Sciences

Background: Naringenin (NAR) is a flavonoid with excellent antioxidant and neuroprotective potential that is limited by its low solubility. Thus, solid dispersions with β-cyclodextrin (β-CD), hydroxypropyl-β-cyclodextrin (HP-β-CD), hydroxypropylm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0feb50db12fa1a433c1ad40472a387e9

Identification of the first-in-class dual inhibitors of human DNA topoisomerase IIα and indoleamine-2,3-dioxygenase 1 (IDO 1) with strong anticancer properties.

Autor: Kaproń, Barbara¹ (AUTHOR) barbara.kapron@umlub.pl, Płazińska, Anita² (AUTHOR), Płaziński, Wojciech^2,3 (AUTHOR), Plech, Tomasz⁴ (AUTHOR)

Publikováno v: Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2023, Vol. 38 Issue 1, p192-202. 11p.