Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Anita Nomden"'
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155317 (2016)
In oligodendrocytes (OLGs), an indirect, transcytotic pathway is mediating transport of de novo synthesized PLP, a major myelin specific protein, from the apical-like plasma membrane to the specialized basolateral-like myelin membrane to prevent its
Externí odkaz:
https://doaj.org/article/7f9c2327eceb4555bdb2c6e85ef24608
Autor:
Charlotte E. Teunissen, Anita Nomden, Dick Hoekstra, Jenny C. de Jonge, Wia Baron, Marjolein Bijlard
Publikováno v:
Glia. 62:927-942
In the central nervous system, the extracellular matrix (ECM) compound laminin-2, present on developing axons, is essential in regulating oligodendrocyte (OLG) maturation. For example, laminin-2 is involved in mediating interactions between integrins
Autor:
Mirjana Stancic, Josephine M. J. Stoffels, Jenny C. de Jonge, Dan Ma, Olaf Maier, Wia Baron, Miriam E. van Strien, Zuzana Siskova, Robin J.M. Franklin, Dick Hoekstra, Charles ffrench-Constant, Anita Nomden, Chao Zhao
Publikováno v:
Brain, 136, 116-131. Oxford University Press
Stoffels, J M J, de Jonge, J C, Stancic, M, Nomden, A, van Strien, M E, Ma, D, Siskova, Z, Maier, O, Ffrench-Constant, C, Franklin, R J M, Hoekstra, D, Zhao, C & Baron, W 2013, ' Fibronectin aggregation in multiple sclerosis lesions impairs remyelination ', Brain, vol. 136, pp. 116-131 . https://doi.org/10.1093/brain/aws313
Stoffels, J M J, de Jonge, J C, Stancic, M, Nomden, A, van Strien, M E, Ma, D, Siskova, Z, Maier, O, Ffrench-Constant, C, Franklin, R J M, Hoekstra, D, Zhao, C & Baron, W 2013, ' Fibronectin aggregation in multiple sclerosis lesions impairs remyelination ', Brain, vol. 136, pp. 116-131 . https://doi.org/10.1093/brain/aws313
Remyelination following central nervous system demyelination is essential to prevent axon degeneration. However, remyelination ultimately fails in demyelinating diseases such as multiple sclerosis. This failure of remyelination is likely mediated by
Autor:
Wia Baron, Jenny Dallinga-de Jonge, Bert-Jan Klunder, Dick Hoekstra, Anita Nomden, Marjolein Bijlard
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155317 (2016)
PLoS ONE, 11(5):e0155317. PUBLIC LIBRARY SCIENCE
PLoS ONE
PLoS ONE, 11(5):e0155317. PUBLIC LIBRARY SCIENCE
PLoS ONE
In oligodendrocytes (OLGs), an indirect, transcytotic pathway is mediating transport of de novo synthesized PLP, a major myelin specific protein, from the apical-like plasma membrane to the specialized basolateral-like myelin membrane to prevent its
Publikováno v:
Journal of Neuroscience Research, 90(2), 388-398. Wiley-Blackwell
Toll-like receptors (TLRs) play a key role in controlling innate immune responses to a wide variety of pathogen-associated molecules as well as endogenous signals. In addition, TLR expression within nonimmune cells has been recognized as as modulator
Lovastatin Induces the Formation of Abnormal Myelin-Like Membrane Sheets in Primary Oligodendrocytes
Publikováno v:
Glia, 57(4), 402-413. Wiley
Statins, well-known inhibitors of cholesterol synthesis and protein isoprenylation, have been proposed as therapeutic drugs for multiple sclerosis (MS). As lovastatin and simvastatin, which are currently tested for their use in MS, can cross the bloo
Autor:
Dick Hoekstra, Jenny C. de Jonge, Wia Baron, Sanjay Tyagi, Marjolein Bijlard, Hans de Vries, Anita Nomden, Bert Klunder
Publikováno v:
Molecular and Cellular Biology, 35(4), 675-687. AMER SOC MICROBIOLOGY
Myelination of axons by oligodendrocytes is essential for saltatory nerve conduction. To form myelin membranes, a coordinated synthesis and subsequent polarized transport of myelin components are necessary. Here, we show that as part of the mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e7d54164c38deda16dde192e963c7c
https://research.rug.nl/en/publications/49d73ead-08a9-4e8f-ac05-e92aff36714c
https://research.rug.nl/en/publications/49d73ead-08a9-4e8f-ac05-e92aff36714c
Autor:
Dick Hoekstra, Wia Baron, Hans de Vries, Elisabeth Trifilieff, Anita Nomden, Annechien Plat, Bert Klunder, Hande Ozgen, Jenny C. de Jonge
Publikováno v:
Molecular and Cellular Biology, 35(1), 288-302. AMER SOC MICROBIOLOGY
Myelin membranes are sheet-like extensions of oligodendrocytes that can be considered membrane domains distinct from the cell's plasma membrane. Consistent with the polarized nature of oligodendrocytes, we demonstrate that transcytotic transport of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14cd4018f4e9a1a91a64b6dac7172018
https://research.rug.nl/en/publications/0f6244c4-e4a6-480c-807f-68ddd02a516b
https://research.rug.nl/en/publications/0f6244c4-e4a6-480c-807f-68ddd02a516b
Publikováno v:
Nucleic Acids Research, 29(10), 2079-2087. Oxford University Press
Oligonucleotides (ODNs) can be employed as effective gene-specific regulators. However, before ODNs can reach their targets, several physical barriers have to be overcome, as although ODNs may pass cell membranes, most become sequestered in endocytic
Autor:
Wia, Baron, Marjolein, Bijlard, Anita, Nomden, Jenny C, de Jonge, Charlotte E, Teunissen, Dick, Hoekstra
Publikováno v:
Glia. 62(6)
In the central nervous system, the extracellular matrix (ECM) compound laminin-2, present on developing axons, is essential in regulating oligodendrocyte (OLG) maturation. For example, laminin-2 is involved in mediating interactions between integrins