Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Anita Niedziela-Majka"'
Autor:
Weimei Xing, Ona Barauskas, Thorsten Kirschberg, Anita Niedziela-Majka, Michael Clarke, Gabriel Birkus, Perry Weissburg, Xiaohong Liu, Brian E Schultz, Roman Sakowicz, HyockJoo Kwon, Joy Y Feng
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181969 (2017)
Influenza polymerase is a heterotrimer composed of polymerase acidic protein A (PA) and basic proteins 1 (PB1) and 2 (PB2). The endonuclease active site, located in the PA subunit, cleaves host mRNA to prime viral mRNA transcription, and is essential
Externí odkaz:
https://doaj.org/article/214d6c14bef247f8a2cf1c7bae8f111c
Autor:
Hyock Joo Kwon, Weimei Xing, Katie Chan, Anita Niedziela-Majka, Katherine M Brendza, Thorsten Kirschberg, Darryl Kato, John O Link, Guofeng Cheng, Xiaohong Liu, Roman Sakowicz
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0122844 (2015)
Ledipasvir, a direct acting antiviral agent (DAA) targeting the Hepatitis C Virus NS5A protein, exhibits picomolar activity in replicon cells. While its mechanism of action is unclear, mutations that confer resistance to ledipasvir in HCV replicon ce
Externí odkaz:
https://doaj.org/article/2ec4378953f54de7b0076a7adeb703bd
Autor:
Sarah E Boyce, Neeraj Tirunagari, Anita Niedziela-Majka, Jason Perry, Melanie Wong, Elaine Kan, Leanna Lagpacan, Ona Barauskas, Magdeleine Hung, Martijn Fenaux, Todd Appleby, William J Watkins, Uli Schmitz, Roman Sakowicz
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84808 (2014)
Elucidation of the mechanism of action of the HCV NS5B polymerase thumb site II inhibitors has presented a challenge. Current opinion holds that these allosteric inhibitors stabilize the closed, inactive enzyme conformation, but how this inhibition i
Externí odkaz:
https://doaj.org/article/511db7137be1485baa683530d590daed
Autor:
Magdeleine Hung, Anita Niedziela-Majka, Debi Jin, Melanie Wong, Stephanie Leavitt, Katherine M Brendza, Xiaohong Liu, Roman Sakowicz
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58035 (2013)
During human immunodeficiency virus type-1 (HIV-1) virion maturation, capsid proteins undergo a major rearrangement to form a conical core that protects the viral nucleoprotein complexes. Mutations in the capsid sequence that alter the stability of t
Externí odkaz:
https://doaj.org/article/0dc931a917b94da785019ee58099729c
Autor:
Mini Balakrishnan, Stephen R Yant, Luong Tsai, Christopher O'Sullivan, Rujuta A Bam, Angela Tsai, Anita Niedziela-Majka, Kirsten M Stray, Roman Sakowicz, Tomas Cihlar
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74163 (2013)
HIV-1 integrase (IN) is the target for two classes of antiretrovirals: i) the integrase strand-transfer inhibitors (INSTIs) and ii) the non-catalytic site integrase inhibitors (NCINIs). NCINIs bind at the IN dimer interface and are thought to interfe
Externí odkaz:
https://doaj.org/article/ab7f85858d794836a0e3f22e87f9d8d3
Autor:
Richard L. Mackman, Rao Kalla, Darius Babusis, Jared Pitts, Kimberly T. Barrett, Kwon Chun, Venice Du Pont, Lauren Rodriguez, Jasmine Moshiri, Yili Xu, Michael Lee, Gary Lee, Blake Bleier, Anh-Quan Nguyen, B. Michael O’Keefe, Andrea Ambrosi, Meredith Cook, Joy Yu, Elodie Dempah, Elaine Bunyan, Nicholas C. Riola, Xianghan Lu, Renmeng Liu, Ashley Davie, Tien-Ying Hsiang, Michael Gale, Anita Niedziela-Majka, Joy Y. Feng, Charlotte Hedskog, John P. Bilello, Raju Subramanian, Tomas Cihlar
Remdesivir1is an amidate prodrug that releases the monophosphate of nucleoside GS-441524 (2) into lung cells thereby forming the bioactive triphosphate2-NTP.2-NTP, an analog of ATP, inhibits the SARS-CoV-2 RNA-dependent RNA polymerase replication and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f124f071d22852c94170b2ccfc17e415
https://doi.org/10.1101/2023.04.28.538473
https://doi.org/10.1101/2023.04.28.538473
Autor:
Alejandro M. Gomez, R. Camille Brewer, Jae-Seung Moon, Suman Acharya, Sarah Kongpachith, Qian Wang, Shaghayegh Jahanbani, Heidi H. Wong, Tobias V. Lanz, Zelda Z. Love, Gundula Min-Oo, Anita Niedziela-Majka, William H. Robinson
Anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis (RA) and have long been considered to contribute to pathogenesis. In this study, we sequenced the plasmablast antibody repertoires of RA patients and functionally ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2342c6dd5b03f7fbedc2f66709236c7
https://doi.org/10.1101/2023.03.08.531560
https://doi.org/10.1101/2023.03.08.531560
Autor:
Dara Burdette, Anastasia Hyrina, Zhijuan Song, Rudolf K. Beran, Tara Cheung, Sarah Gilmore, Tetsuya Kobayashi, Li Li, Yang Liu, Anita Niedziela-Majka, Jonathan Medley, Upasana Mehra, Philip Morganelli, Nikolai Novikov, Congrong Niu, Danny Tam, Jennifer Tang, Jianhong Wang, Qin Yue, Simon P. Fletcher, Meghan M. Holdorf, William E. Delaney, Becket Feierbach, Scott Lazerwith
Publikováno v:
Antimicrobial agents and chemotherapy.
The standard of care for the treatment of chronic hepatitis B (CHB) is typically lifelong treatment with nucleos(t)ide analogs (NAs), which suppress viral replication and provide long-term clinical benefits. However, infectious virus can still be det
Autor:
Qi Liu, Chien-Hung Chou, Eda Canales, Roman Sakowicz, Steven Bondy, Tomas Cihlar, Albert Liclican, Diana M. Brainard, Anita Niedziela-Majka, William Rowe, Nikolai Novikov, Shekeba Ahmadyar, John R. Somoza, Randall L. Halcomb, Cheryl K. McDonald, Carina E. Cannizzaro, Nicolas Margot, Debi Jin, George Stepan, Qiaoyin Wu, Eric Hu, Judy Mwangi, Stephanie A. Leavitt, Todd C. Appleby, Robert L. Anderson, Scott E. Lazerwith, Schroeder Scott D, Tse Winston C, Gediminas Brizgys, Rebecca Begley, Yili Xu, Scott Sellers, Scott A. Wolckenhauer, Wesley I. Sundquist, Derek Hansen, Philip Morganelli, Andrew Mulato, Sheila Clancy, Xiaohong Liu, Anna Chiu, Eric S. Daar, Renee R. Ram, S. Swaminathan, Anne E. Chester, Melanie H. Wong, Ya-Pei Liu, John O. Link, Michael Graupe, Luong K. Tsai, Christian Callebaut, Latesh Lad, William E. Lee, Rujuta A. Bam, Terrence Z. Cai, Bing Lu, John K. Ling, Roland D. Saito, Magdeleine Hung, Armando G. Villaseñor, Peter Ruane, Nikos Pagratis, Martin S. Rhee, David Koditek, Gordon Crofoot, Giuseppe A. Papalia, Stephen R. Yant, Rob Hyland, Helen Yu, Jim Zheng, Jennifer R. Zhang, Gary I. Sinclair, Jiayao Li, Eric Singer
Publikováno v:
Nature
Oral antiretroviral agents provide life-saving treatments for millions of people living with HIV, and can prevent new infections via pre-exposure prophylaxis1–5. However, some people living with HIV who are heavily treatment-experienced have limite
Autor:
Melanie H. Wong, Helen Yu, Daniel Gonik, Derek Hansen, Wesley I. Sundquist, Debi Jin, Anita Niedziela-Majka, Nikolai Novikov, William M. McDougall, Shekeba Ahmadyar, Albert Liclican, Jill M. Perreira, Andrew Mulato, George Stepan, Jennifer R. Zhang, Bing Lu, Magdeleine Hung, Giuseppe A. Papalia, Renee R. Ram, John O. Link, Kevin Chou, Abraham L. Brass, Eric E. Paoli, Stephen R. Yant, Jim Zheng, Eric Singer, Eric Hu, Tomas Cihlar, Schroeder Scott D, Tse Winston C
Publikováno v:
Nat Med
People living with HIV (PLWH) have expressed concern about the life-long burden and stigma associated with taking pills daily and can experience medication fatigue that might lead to suboptimal treatment adherence and the emergence of drug-resistant