Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Anita M. Goodman"'
Publikováno v:
The American Journal of Medicine. 103:491-497
PURPOSE: To study the efficacy and safety of various dosages of metformin as compared with placebo in patients with type II diabetes mellitus. PATIENTS AND METHODS: A 14-week, multicenter, double-blind, dose-response study was conducted. After a 3-we
Autor:
Anita M. Goodman, Ralph A. DeFronzo
Publikováno v:
New England Journal of Medicine. 333:541-549
Background Sulfonylurea drugs have been the only oral therapy available for patients with non-insulin-dependent diabetes mellitus (NIDDM) in the United States. Recently, however, metformin has been approved for the treatment of NIDDM. Methods We perf
Publikováno v:
Journal of addiction medicine. 2(1)
Acamprosate, in conjunction with psychosocial treatment, has demonstrated efficacy in maintaining abstinence in alcohol-dependent patients in multiple clinical trials. Data from 13 short-term (≤26 weeks) and long-term (≥48 weeks) clinical trials
Autor:
Leslie Z. Benet, Chui Y. Liu, Anita M. Goodman, Nancy C. Sambol, Janie Chiang, John H. Karam, Emil T. Lin, Michael O'Conner
Publikováno v:
Journal of clinical pharmacology. 36(11)
This study was conducted to assess the effect of noninsulin-dependent diabetes mellitus (NIDDM) and gender on the pharmacokinetics of metformin and to investigate whether or not metformin exhibits dose-dependent pharmacokinetics. The pharmacodynamic
Autor:
Emil T. Lin, Chui Y. Liu, Nancy C. Sambol, Janie Chiang, Martin G. Cogan, Anita M. Goodman, Leslie Z. Benet
Publikováno v:
Journal of clinical pharmacology. 35(11)
The effects of renal impairment and age on the pharmacokinetics of metformin were evaluated. The subjects, including 6 young, 12 elderly, and 3 middle-age healthy adults and 15 adults with various degrees of chronic renal impairment (CRI) each were g
Publikováno v:
American Journal of Hematology. 5:43-49
Because unexplained megaloblastic erythroid maturation occurs in patients with primary refractory sideroblastic anemia (PRSA), deoxyuridine (dU) suppression tests using125 I-UdR were performed on bone marrow from five patients with PRSA. All patients
Publikováno v:
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry. 68:421-423
1. 1. Red cell membranes were isolated from rhesus-monkey erythrocytes and their proteins were analyzed by polyacrylamide gel electrophoresis in sodium dodecyl sulfate and compared to the membrane protein pattern of human red cells. 2. 2. Rhesus-monk
Publikováno v:
Archives of ophthalmology (Chicago, Ill. : 1960). 101(7)
• The incidence of clinically apparent retinal changes in 35 anemic patients and 35 age- and sex-matched control subjects was studied. Retinal photographs of all subjects were obtained. From these, all vascular and extravascular retinal lesions wer
Publikováno v:
Archives of Internal Medicine. 141:223
• Two patients became severely pancytopenic while receiving azathioprine in low dosages for treatment of connective-tissue diseases. While mild hematologic complications are common with this drug, we believe that the degree of bone marrow suppressi