Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Anita M. Fletcher"'
Autor:
David M. Yurek, Anita M. Fletcher, Matthew McShane, Tomasz H. Kowalczyk, Linas Padegimas, Marcy R. Weatherspoon, Michael D. Kaytor, Mark J. Cooper, Assem G. Ziady
Publikováno v:
Molecular Imaging, Vol 10 (2011)
In this study, we used bioluminescence imaging (BLI) to track long-term transgene activity following the transfection of brain cells using a nonviral gene therapy technique. Formulations of deoxyribonucleic acid (DNA) combined with 30-mer lysine poly
Externí odkaz:
https://doaj.org/article/74fd1eaad961438ba622f377fd517651
Autor:
Chen Zhang, E. Truit, Anita M. Fletcher, Kristine S. Ziemba, George M. Smith, Ying Jin, Biswarup Ghosh, David M. Yurek
Publikováno v:
Experimental Neurology. 250:156-164
Different experimental and clinical strategies have been used to promote survival of transplanted embryonic ventral mesencephalic (VM) neurons. However, few studies have focused on the long-distance growth of dopaminergic axons from VM transplants. T
Publikováno v:
Neurochemical Research. 35:531-539
Lesions of the nigrostriatal pathway are known to induce a compensatory up-regulation of various neurotrophic factors. In this study we examined protein content of basic fibroblast growth factor (FGF-2) in tissue samples taken from the ventral midbra
Autor:
Assem G. Ziady, Kim B. Seroogy, Tomasz H. Kowalczyk, Anita M. Fletcher, Joseph Molter, Linas Padegimas, David M. Yurek, Mark J. Cooper, George M. Smith
Publikováno v:
Molecular Therapy. 17(4):641-650
This study demonstrates proof of concept for delivery and expression of compacted plasmid DNA in the central nervous system. Plasmid DNA was compacted with polyethylene glycol substituted lysine 30-mer peptides, forming rod-like nanoparticles with di
Autor:
Stephen W. Scheff, Phillip J. Kraemer, Dev K. Singh, Gordon Campbell, Renuka M. Prasad, Derek Mace, David M. Yurek, Anita M. Fletcher, Peter Dendle, Irina Doubinskaia
Publikováno v:
Journal of Neurotrauma. 18:1019-1029
This study examined the effects of 4 weeks of binge ethanol administration (BEAn) on the behavioral outcome in rats after lateral fluid percussion (FP) brain injury. Rats were intragastrically given 7.5 mL/kg of either 40% ethanol in 5% glucose solut
Publikováno v:
Neurochemical research. 39(8)
Current therapies for Parkinson’s disease (PD) offer symptomatic relief but do not provide a cure or slow the disease process. Treatments that could halt progression of the disease or help restore function to damaged neurons would be of substantial
Autor:
Michael D. Kaytor, Matthew McShane, Assem G. Ziady, Marcy R. Weatherspoon, Anita M. Fletcher, David M. Yurek, Tomasz Kowalczyk, Linas Padegimas, Mark J. Cooper
Publikováno v:
Molecular Imaging, Vol 10 (2011)
In this study, we used bioluminescence imaging (BLI) to track long-term transgene activity following the transfection of brain cells using a nonviral gene therapy technique. Formulations of deoxyribonucleic acid (DNA) combined with 30-mer lysine poly
Publikováno v:
Neuroscience. 194
A goal of our studies is to develop a potential therapeutic for Parkinson's disease (PD) by a human glial cell line-derived neurotrophic factor (hGDNF) expression plasmid administered to the rat striatum as a compacted DNA nanoparticle (DNP) and whic