Early increase in anti-inflammatory biomarkers is associated with the development of multiple organ dysfunction syndrome in severely injured trauma patients

Autor: Markus W Hollmann, Derek JB Kleinveld, Anita M Tuip-de Boer, Nicole P Juffermans

Publikováno v: Trauma Surgery & Acute Care Open, Vol 4, Iss 1 (2019)

Background As a result of improvements in the early resuscitation phase of trauma, mortality is largely driven by later mortality due to multiple organ dysfunction syndrome (MODS), which may be mediated by an early overdrive in the host immune respon

Externí odkaz: https://doaj.org/article/cf9fe572b6c048a29b976b10c3059907

Anti-C5a antibody vilobelimab treatment and the effect on biomarkers of inflammation and coagulation in patients with severe COVID-19: a substudy of the phase 2 PANAMO trial

Autor: Endry H. T. Lim, Alexander P. J. Vlaar, Lieuwe D. J. Bos, Lonneke A. van Vught, Anita M. Tuip-de Boer, Romein W. G. Dujardin, Maria Habel, Zhongli Xu, Matthijs C. Brouwer, Diederik van de Beek, Sanne de Bruin, the Amsterdam UMC COVID-19 Biobank Investigators

Publikováno v: Respiratory Research, Vol 23, Iss 1, Pp 1-6 (2022)

Abstract We recently reported in the phase 3 PANAMO trial that selectively blocking complement 5a (C5a) with vilobelimab led to improved survival in critically ill COVID-19 patients. C5a is an important contributor to the innate immune system and can

Externí odkaz: https://doaj.org/article/5d4d30322d4340d189e888acf0f705da

Clinical features and prognostic factors in Covid-19: A prospective cohort study

Autor: Sanne de Bruin, Lieuwe D. Bos, Marian A. van Roon, Anita M. Tuip-de Boer, Alex R. Schuurman, Marleen J.A. Koel-Simmelinck, Harm Jan Bogaard, Pieter Roel Tuinman, Michiel A. van Agtmael, Jörg Hamann, Charlotte E. Teunissen, W. Joost Wiersinga, A.H. (Koos) Zwinderman, Matthijs C. Brouwer, Diederik van de Beek, Alexander P.J. Vlaar, Michiel van Agtmael, Anne Geke Algera, Brent Appelman, Frank van Baarle, Diane Bax, Martijn Beudel, Marije Bomers, Peter Bonta, Lieuwe Bos, Michela Botta, Justin de Brabander, Godelieve de Bree, David T.P. Buis, Marianna Bugiani, Esther Bulle, Osoul Chouchane, Alex Cloherty, Maurits C.F.J. de Rotte, Mirjam Dijkstra, Dave A. Dongelmans, Romein W.G. Dujardin, Paul Elbers, Lucas Fleuren, Suzanne Geerlings, Theo Geijtenbeek, Armand Girbes, Bram Goorhuis, Martin P. Grobusch, Florianne Hafkamp, Laura Hagens, Jorg Hamann, Vanessa Harris, Robert Hemke, Sabine M. Hermans, Leo Heunks, Markus Hollmann, Janneke Horn, Joppe W. Hovius, Menno D. de Jong, Rutger Koning, Endry H.T. Lim, Niels van Mourik, Jeannine Nellen, Esther J. Nossent, Frederique Paulus, Edgar Peters, Dan A.I. Piña-Fuentes, Tom van der Poll, Bennedikt Preckel, Jan M. Prins, Jorinde Raasveld, Tom Reijnders, Michiel Schinkel, Femke A.P. Schrauwen, Marcus J. Schultz, Alex Schuurmans, Jaap Schuurmans, Kim Sigaloff, Marleen A. Slim, Patrick Smeele, Marry Smit, Cornelis S. Stijnis, Willemke Stilma, Charlotte Teunissen, Patrick Thoral, Anissa M. Tsonas, Pieter R. Tuinman, Marc van der Valk, Denise Veelo, Carolien Volleman, Heder de Vries, Lonneke A. Vught, Michèle van Vugt, Dorien Wouters, A.H (Koos) Zwinderman

Publikováno v: EBioMedicine, Vol 67, Iss , Pp 103378- (2021)

Background: Mortality rates are high among hospitalized patients with COVID-19, especially in those intubated on the ICU. Insight in pathways associated with unfavourable outcome may lead to new treatment strategies. Methods: We performed a prospecti

Externí odkaz: https://doaj.org/article/39c08e0ba3924a9abcf24a1846852f13

Validation of volatile metabolites of pulmonary oxidative injury: a bench to bedside study

Autor: Dominic Fenn, Thijs A. Lilien, Laura A. Hagens, Marry R. Smit, Nanon F.L. Heijnen, Anita M. Tuip-de Boer, Anne H. Neerincx, Korneliusz Golebski, Dennis C.J.J. Bergmans, Ronny M. Schnabel, Marcus J. Schultz, Anke H. Maitland-van der Zee, Paul Brinkman, Lieuwe D.J. Bos

Publikováno v: ERJ Open Research, 9(2):00427-2022. BMJ Publishing Group
ERJ Open Research, 9(2):00427-2022. European Respiratory Society
DARTS Consortium 2023, ' Validation of volatile metabolites of pulmonary oxidative injury : a bench to bedside study ', ERJ Open Research, vol. 9, no. 2, 00427-2022 . https://doi.org/10.1183/23120541.00427-2022

BackgroundChanges in exhaled volatile organic compounds (VOCs) can be used to discriminate between respiratory diseases, and increased concentrations of hydrocarbons are commonly linked to oxidative stress. However, the VOCs identified are inconsiste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a36d99346c999cee2240a1094f6d39
https://doi.org/10.1183/23120541.00427-2022

Shock-Driven Endotheliopathy in Trauma Patients Is Associated with Leucocyte Derived Extracellular Vesicles

Autor: Romein W. G. Dujardin, Jeske E. C. Kisters, Mathijs R. Wirtz, Najat Hajji, Anita M. Tuip-de Boer, Jakob Stensballe, Pär I. Johansson, Karim Brohi, Ross A. Davenport, Christine Gaarder, Simon Stanworth, Marc Maegele, Rienk Nieuwland, Edwin van der Pol, Nicole P. Juffermans

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 24; Pages: 15990
Dujardin, R W G, Kisters, J E C, Wirtz, M R, Hajji, N, Tuip-de Boer, A M, Stensballe, J, Johansson, P I, Brohi, K, Davenport, R A, Gaarder, C, Stanworth, S, Maegele, M, Nieuwland, R, van der Pol, E & Juffermans, N P 2022, ' Shock-Driven Endotheliopathy in Trauma Patients Is Associated with Leucocyte Derived Extracellular Vesicles ', International Journal of Molecular Sciences, vol. 23, no. 24, 15990 . https://doi.org/10.3390/ijms232415990
International journal of molecular sciences, 23(24):15990. Multidisciplinary Digital Publishing Institute (MDPI)

Endotheliopathy following trauma is associated with poor outcome, but the underlying mechanisms are unknown. This study hypothesized that an increased extracellular vesicle (EV) concentration is associated with endotheliopathy after trauma and that r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32bbefc4c423c09d6c11ae9a954c74c