Lactated Ringers, albumin and mannitol as priming during cardiopulmonary bypass reduces pulmonary edema in rats compared with hydroxyethyl starch

Autor: Anne M. Beukers, Anoek L. I. van Leeuwen, Roselique Ibelings, Anita M. Tuip-de Boer, Carolien S. E. Bulte, Susanne Eberl, Charissa E. van den Brom

Publikováno v: Intensive Care Medicine Experimental, Vol 12, Iss 1, Pp 1-11 (2024)

Abstract Background Endothelial disorders with edema formation and microcirculatory perfusion disturbances are common in cardiac surgery with cardiopulmonary bypass (CPB) and contribute to disturbed tissue oxygenation resulting in organ dysfunction.

Externí odkaz: https://doaj.org/article/f9f118e8e27e468cb19e855640200731

Anti-C5a antibody vilobelimab treatment and the effect on biomarkers of inflammation and coagulation in patients with severe COVID-19: a substudy of the phase 2 PANAMO trial

Autor: Endry H. T. Lim, Alexander P. J. Vlaar, Lieuwe D. J. Bos, Lonneke A. van Vught, Anita M. Tuip-de Boer, Romein W. G. Dujardin, Maria Habel, Zhongli Xu, Matthijs C. Brouwer, Diederik van de Beek, Sanne de Bruin, the Amsterdam UMC COVID-19 Biobank Investigators

Publikováno v: Respiratory Research, Vol 23, Iss 1, Pp 1-6 (2022)

Abstract We recently reported in the phase 3 PANAMO trial that selectively blocking complement 5a (C5a) with vilobelimab led to improved survival in critically ill COVID-19 patients. C5a is an important contributor to the innate immune system and can

Externí odkaz: https://doaj.org/article/5d4d30322d4340d189e888acf0f705da

Validation of volatile metabolites of pulmonary oxidative injury: a bench to bedside study

Autor: Dominic Fenn, Thijs A. Lilien, Laura A. Hagens, Marry R. Smit, Nanon F.L. Heijnen, Anita M. Tuip-de Boer, Anne H. Neerincx, Korneliusz Golebski, Dennis C.J.J. Bergmans, Ronny M. Schnabel, Marcus J. Schultz, Anke H. Maitland-van der Zee, Paul Brinkman, Lieuwe D.J. Bos

Publikováno v: ERJ Open Research, Vol 9, Iss 2 (2023)

Background Changes in exhaled volatile organic compounds (VOCs) can be used to discriminate between respiratory diseases, and increased concentrations of hydrocarbons are commonly linked to oxidative stress. However, the VOCs identified are inconsist

Externí odkaz: https://doaj.org/article/4ad35999d3744212916af4e1309aa61f

Transfusion of female blood in a rat model is associated with red blood cells entrapment in organs.

Autor: Abdulrahman Alshalani, Marit B de Wissel, Anita M Tuip-de Boer, Joris J T H Roelofs, Robin van Bruggen, Jason P Acker, Nicole P Juffermans

Publikováno v: PLoS ONE, Vol 18, Iss 11, p e0288308 (2023)

Transfusion of red blood cells (RBCs) has been associated with adverse outcomes. Mechanisms may be related to donor sex and biological age of RBC. This study hypothesized that receipt of female blood is associated with decreased post-transfusion reco

Externí odkaz: https://doaj.org/article/75511daef9ad4b679f2586b0c2ec82cc

Clinical features and prognostic factors in Covid-19: A prospective cohort study

Autor: Sanne de Bruin, Lieuwe D. Bos, Marian A. van Roon, Anita M. Tuip-de Boer, Alex R. Schuurman, Marleen J.A. Koel-Simmelinck, Harm Jan Bogaard, Pieter Roel Tuinman, Michiel A. van Agtmael, Jörg Hamann, Charlotte E. Teunissen, W. Joost Wiersinga, A.H. (Koos) Zwinderman, Matthijs C. Brouwer, Diederik van de Beek, Alexander P.J. Vlaar, Michiel van Agtmael, Anne Geke Algera, Brent Appelman, Frank van Baarle, Diane Bax, Martijn Beudel, Marije Bomers, Peter Bonta, Lieuwe Bos, Michela Botta, Justin de Brabander, Godelieve de Bree, David T.P. Buis, Marianna Bugiani, Esther Bulle, Osoul Chouchane, Alex Cloherty, Maurits C.F.J. de Rotte, Mirjam Dijkstra, Dave A. Dongelmans, Romein W.G. Dujardin, Paul Elbers, Lucas Fleuren, Suzanne Geerlings, Theo Geijtenbeek, Armand Girbes, Bram Goorhuis, Martin P. Grobusch, Florianne Hafkamp, Laura Hagens, Jorg Hamann, Vanessa Harris, Robert Hemke, Sabine M. Hermans, Leo Heunks, Markus Hollmann, Janneke Horn, Joppe W. Hovius, Menno D. de Jong, Rutger Koning, Endry H.T. Lim, Niels van Mourik, Jeannine Nellen, Esther J. Nossent, Frederique Paulus, Edgar Peters, Dan A.I. Piña-Fuentes, Tom van der Poll, Bennedikt Preckel, Jan M. Prins, Jorinde Raasveld, Tom Reijnders, Michiel Schinkel, Femke A.P. Schrauwen, Marcus J. Schultz, Alex Schuurmans, Jaap Schuurmans, Kim Sigaloff, Marleen A. Slim, Patrick Smeele, Marry Smit, Cornelis S. Stijnis, Willemke Stilma, Charlotte Teunissen, Patrick Thoral, Anissa M. Tsonas, Pieter R. Tuinman, Marc van der Valk, Denise Veelo, Carolien Volleman, Heder de Vries, Lonneke A. Vught, Michèle van Vugt, Dorien Wouters, A.H (Koos) Zwinderman

Publikováno v: EBioMedicine, Vol 67, Iss , Pp 103378- (2021)

Background: Mortality rates are high among hospitalized patients with COVID-19, especially in those intubated on the ICU. Insight in pathways associated with unfavourable outcome may lead to new treatment strategies. Methods: We performed a prospecti

Externí odkaz: https://doaj.org/article/39c08e0ba3924a9abcf24a1846852f13