Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Anita Lehner"'
Autor:
Jana Neuhold, Katharina Radakovics, Anita Lehner, Florian Weissmann, Maria Queralt Garcia, Mari Carmen Romero, Nicholas S. Berrow, Peggy Stolt-Bergner
Publikováno v:
BMC Biotechnology, Vol 20, Iss 1, Pp 1-15 (2020)
Abstract Background Recombinant protein production and purification of large protein complexes in eukaryotes requires efficient methods to generate multi-gene expression constructs, where each individual gene is under the control of its own promoter
Externí odkaz:
https://doaj.org/article/2a6ec979be764c5d8a30b24ef358dfde
Autor:
Doris Hellerschmied, Anita Lehner, Nina Franicevic, Renato Arnese, Chloe Johnson, Antonia Vogel, Anton Meinhart, Robert Kurzbauer, Luiza Deszcz, Linn Gazda, Michael Geeves, Tim Clausen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Myosin, a motor protein essential for intracellular transport to muscle contraction, requires a chaperone UNC-45 for folding and assembly. Here authors use in vitro reconstitution and structural biology to characterize the interplay between UNC-45 an
Externí odkaz:
https://doaj.org/article/988d6ef9a9a34ef79788fa29755892f7
Autor:
Juraj Ahel, Anita Lehner, Antonia Vogel, Alexander Schleiffer, Anton Meinhart, David Haselbach, Tim Clausen
Publikováno v:
eLife, Vol 9 (2020)
RNF213 is the major susceptibility factor for Moyamoya disease, a progressive cerebrovascular disorder that often leads to brain stroke in adults and children. Characterization of disease-associated mutations has been complicated by the enormous size
Externí odkaz:
https://doaj.org/article/75607b9332b1404caeb8b255f07add85
Autor:
Doris Hellerschmied, Max Roessler, Anita Lehner, Linn Gazda, Karel Stejskal, Richard Imre, Karl Mechtler, Alexander Dammermann, Tim Clausen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The U-box ubiquitin ligase UFD-2 is one of the most abundant components of the ubiquitin proteasome system in muscle cells. Here the authors perform in vitro and in vivo experiments and show that UFD-2 has E3 ligase activity and that it ubiquitinates
Externí odkaz:
https://doaj.org/article/5d615670363d4e18b6f7439c5d092bfd
Autor:
Jakob Fuhrmann, Beata Mierzwa, Débora B. Trentini, Silvia Spiess, Anita Lehner, Emmanuelle Charpentier, Tim Clausen
Publikováno v:
Cell Reports, Vol 3, Iss 6, Pp 1832-1839 (2013)
Many cellular pathways are regulated by the competing activity of protein kinases and phosphatases. The recent identification of arginine phosphorylation as a protein modification in bacteria prompted us to analyze the molecular basis of targeting ph
Externí odkaz:
https://doaj.org/article/120de2e4669f4e0392ecdb9a73ae4550
Autor:
Gerhard Fischer, Luiza Deszcz, Antonia Vogel, Daniel B. Grabarczyk, Dirk Kessler, Olga A Petrova, Juraj Ahel, Darja Kordic, Alexander Schleiffer, Anton Meinhart, Richard Imre, David Haselbach, Gerd Bader, Tim Clausen, Paul Murphy, Robert Kurzbauer, Irina Grishkovskaya, Rebeca Gogova, Jark Böttcher, Victoria Faas, Peggy Stolt-Bergner, Anita Lehner, Jana Neuhold, Bernhard Wolkerstorfer
Publikováno v:
Nature chemical biology 17(10), 1084-1092 (2021). doi:10.1038/s41589-021-00831-5
Nature chemical biology 17(10), 1084 - 1092 (2021). doi:10.1038/s41589-021-00831-5
HUWE1 is a universal quality-control E3 ligase that marks diverse client proteins for proteasomal degradation. Although the giant HECT enzyme is an essential comp
HUWE1 is a universal quality-control E3 ligase that marks diverse client proteins for proteasomal degradation. Although the giant HECT enzyme is an essential comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b1ac621385c0d023d55ef8d2a62a45
Autor:
Anita Lehner, Mari Carmen Romero, Florian Weissmann, Maria Queralt Garcia, Katharina Radakovics, Jana Neuhold, Peggy Stolt-Bergner, Nicholas S. Berrow
Publikováno v:
BMC Biotechnology
BMC Biotechnology, Vol 20, Iss 1, Pp 1-15 (2020)
BMC Biotechnology, Vol 20, Iss 1, Pp 1-15 (2020)
Background Recombinant protein production and purification of large protein complexes in eukaryotes requires efficient methods to generate multi-gene expression constructs, where each individual gene is under the control of its own promoter and termi
Autor:
Patrick H.N. Celie, Georg Huber, Christian Benda, Anita Lehner, Hüseyin Besir, Cindy Chang, Paola Storici, Peggy Stolt-Bergner, Joop van den Heuvel, Astrid Sander, Gwynn Pardee, Sabine Suppmann, Regis P. Lemaitre, Barbara Giabbai, Wolfgang Knecht, Isabel Zaror, Daniel Weinbruch, Linda H.L. Lua, Tim Bergbrede, Ines Racke, Judith Scholz, David N. Drechsel, Arie Geerlof, Magda Stadnik, Ariane Fischer, Kristina Nordén, Kim Remans
Publikováno v:
J. Struct. Biol. 203, 71-80 (2018)
Baculovirus-insect cell expression system has become one of the most widely used eukaryotic expression systems for heterologous protein production in many laboratories. The availability of robust insect cell lines, serum-free media, a range of vector
Autor:
Anita Lehner, David S. Guttman, G. Adam Mott, Peggy Stolt-Bergner, Jana Neuhold, Darrell Desveaux, Katarzyna Parys, Karin Grünwald, Wolfgang Busch, Youssef Belkhadir, Jixiang Kong, Mehdi Layeghifard, M. Shahid Mukhtar, Santosh B. Satbhai, Nicholas J. Provart, Martin Stegmann, Dominik Mayer, Mathias Madalinski, T C Howton, Natascha Weinberger, Elwira Smakowska-Luzan, Cyril Zipfel
Publikováno v:
Nature. 553:342-346
The cells of multicellular organisms receive extracellular signals using surface receptors. The extracellular domains (ECDs) of cell surface receptors function as interaction platforms, and as regulatory modules of receptor activation. Understanding