Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Anita Ledger"'
Autor:
David Gallego-Ortega, Anita Ledger, Daniel L Roden, Andrew M K Law, Astrid Magenau, Zoya Kikhtyak, Christina Cho, Stephanie L Allerdice, Heather J Lee, Fatima Valdes-Mora, David Herrmann, Robert Salomon, Adelaide I J Young, Brian Y Lee, C Marcelo Sergio, Warren Kaplan, Catherine Piggin, James R W Conway, Brian Rabinovich, Ewan K A Millar, Samantha R Oakes, Tatyana Chtanova, Alexander Swarbrick, Matthew J Naylor, Sandra O'Toole, Andrew R Green, Paul Timpson, Julia M W Gee, Ian O Ellis, Susan J Clark, Christopher J Ormandy
Publikováno v:
PLoS Biology, Vol 13, Iss 12, p e1002330 (2015)
During pregnancy, the ETS transcription factor ELF5 establishes the milk-secreting alveolar cell lineage by driving a cell fate decision of the mammary luminal progenitor cell. In breast cancer, ELF5 is a key transcriptional determinant of tumor subt
Externí odkaz:
https://doaj.org/article/eb537bc34b10404fbde06ea888ba833f
Autor:
Maria Kalyuga, David Gallego-Ortega, Heather J Lee, Daniel L Roden, Mark J Cowley, C Elizabeth Caldon, Andrew Stone, Stephanie L Allerdice, Fatima Valdes-Mora, Rosalind Launchbury, Aaron L Statham, Nicola Armstrong, M Chehani Alles, Adelaide Young, Andrea Egger, Wendy Au, Catherine L Piggin, Cara J Evans, Anita Ledger, Tilman Brummer, Samantha R Oakes, Warren Kaplan, Julia M W Gee, Robert I Nicholson, Robert L Sutherland, Alexander Swarbrick, Matthew J Naylor, Susan J Clark, Jason S Carroll, Christopher J Ormandy
Publikováno v:
PLoS Biology, Vol 10, Iss 12, p e1001461 (2012)
We have previously shown that during pregnancy the E-twenty-six (ETS) transcription factor ELF5 directs the differentiation of mammary progenitor cells toward the estrogen receptor (ER)-negative and milk producing cell lineage, raising the possibilit
Externí odkaz:
https://doaj.org/article/7e94d3be63174fc88be2581b9f7d3521
Autor:
Matthew J. Naylor, Jane E. Visvader, Jason S. Carroll, Peter T. Simpson, Christopher J. Ormandy, Alexander Swarbrick, Paul Shore, Alison Ferguson, Anne-Marie Mooney, Anita Ledger, Sarah A. Best, Renee L. Rogers, Thomas W. Owens
Supplementary Data File containing: Supplementary Figure 1 - Failed lobuloalveolar development in Runx2 knockout transplanted mammary glands is retained at the first day postpartum. Supplementary Figure 2 - Generation and validation of Runx2 floxed;M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa2ab5e099978ff75fe3d84aee668bc
https://doi.org/10.1158/0008-5472.22403157.v1
https://doi.org/10.1158/0008-5472.22403157.v1
Autor:
Anita Ledger, Anne Marie Mooney, Renee L. Rogers, Paul Shore, Thomas W. Owens, Matthew J. Naylor, Jason S. Carroll, Peter T. Simpson, Christopher J. Ormandy, Alexander Swarbrick, Sarah A. Best, Alison Ferguson, Jane E. Visvader
Publikováno v:
Cancer Research. 74:5277-5286
Regulators of differentiated cell fate can offer targets for managing cancer development and progression. Here, we identify Runx2 as a new regulator of epithelial cell fate in mammary gland development and breast cancer. Runx2 is expressed in the epi
Autor:
Anita Ledger, Daniel Schramek, Maria M. Szwarc, Christina Cho, Purna A. Joshi, Heather J. Lee, David Gallego-Ortega, Josef M. Penninger, Christopher J. Ormandy, John P. Lydon, Rama Khokha
Publikováno v:
Development
Progesterone-RankL paracrine signaling has been proposed as a driver of stem cell expansion in the mammary gland, and Elf5 is essential for the differentiation of mammary epithelial progenitor cells. We demonstrate that Elf5 expression is induced by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb50489a0aa95464ef62b0deffc2ba00
https://hdl.handle.net/10453/166472
https://hdl.handle.net/10453/166472
Publikováno v:
Scientific Reports
β1 integrin regulates the response of both normal and cancer cells to their local environment. Although mis-localised in prostate cancer, the role β1 integrin plays in prostate development and carcinogenesis remains unknown. To assess the role of
Autor:
Nicola J. Armstrong, Anita Ledger, Catherine L. Piggin, Christopher J. Ormandy, Maria Kalyuga, Matthew J. Naylor, Alexander Swarbrick, Jason S. Carroll, Adelaide Young, Cara J. Evans, Daniel L. Roden, Aaron L. Statham, C. Elizabeth Caldon, David Gallego-Ortega, M. Chehani Alles, Heather J. Lee, Tilman Brummer, Mark J. Cowley, Stephanie L. Allerdice, Fatima Valdes-Mora, Susan J. Clark, Warren Kaplan, Julia Margaret Wendy Gee, Robert L. Sutherland, Andrea Egger, Robert Ian Nicholson, Rosalind Launchbury, Wendy Wing Yee Au, Samantha R. Oakes, Andrew Stone
Publikováno v:
PLoS Biology, Vol 10, Iss 12, p e1001461 (2012)
PLoS Biology
PLoS Biology
The transcription factor ELF5 is responsible for gene expression patterning underlying molecular subtypes of breast cancer and may mediate acquired resistance to anti-estrogen therapy.
We have previously shown that during pregnancy the E-twenty-
We have previously shown that during pregnancy the E-twenty-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b3f2b7fe954e81ba0a1ae6db69f8e8
https://www.repository.cam.ac.uk/handle/1810/316297
https://www.repository.cam.ac.uk/handle/1810/316297
Autor:
Brian Y. Lee, Paul Timpson, Anita Ledger, Andrew M. K. Law, Andrew R. Green, Robert Salomon, Samantha R. Oakes, Matthew J. Naylor, Fatima Valdes-Mora, Ewan K.A. Millar, Alexander Swarbrick, C. Marcelo Sergio, Zoya Kikhtyak, Brian Rabinovich, Catherine L. Piggin, Christina Cho, Adelaide I. J. Young, Sandra A O'Toole, Susan J. Clark, Warren Kaplan, Christopher J. Ormandy, Julia Margaret Wendy Gee, James R.W. Conway, Tatyana Chtanova, Astrid Magenau, Heather J. Lee, David Herrmann, David Gallego-Ortega, Ian O. Ellis, Daniel L. Roden, Stephanie L. Allerdice
Publikováno v:
PLoS Biology, Vol 13, Iss 12, p e1002330 (2015)
PLoS Biology
PLoS Biology
During pregnancy, the ETS transcription factor ELF5 establishes the milk-secreting alveolar cell lineage by driving a cell fate decision of the mammary luminal progenitor cell. In breast cancer, ELF5 is a key transcriptional determinant of tumor subt