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Autor:
Sani Kizilbash, David Piccioni, Solmaz Sahebjam, John Villano, Kurt Jaeckle, Mary Welch, Xiao-Tang Kong, Matthias Holdhoff, Anita Lammers, Adam Remick, Joel Reid, Jacob Allred, John Port, Ian Lanza, Samuel McBrayer, Charles Kunos, Geoffrey Shapiro, Alex Adjei
Publikováno v:
Neuro-Oncology. 24:vii75-vii75
IDH mutant gliomas depend on glutaminase for glutamate/glutathione generation from glutamine because R-2-hydroxyglutarate inhibits branched chain amino acid transaminase mediated glutamate biosynthesis. Telaglenastat (CB-839 HCl) is a potent glutamin