Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Anita Lövgren-Sandblom"'
Autor:
Peder Rustøen Braadland, Kai Markus Schneider, Annika Bergquist, Antonio Molinaro, Anita Lövgren-Sandblom, Marcus Henricsson, Tom Hemming Karlsen, Mette Vesterhus, Christian Trautwein, Johannes Roksund Hov, Hanns-Ulrich Marschall
Publikováno v:
JHEP Reports, Vol 4, Iss 11, Pp 100561- (2022)
Background & Aims: Farnesoid X receptor (FXR) agonists and fibroblast growth factor 19 (FGF19) analogues suppress bile acid synthesis and are being investigated for their potential therapeutic efficacy in cholestatic liver diseases. We investigated w
Externí odkaz:
https://doaj.org/article/5da6d93d1b724ac6b4d7ca6c74b5971b
Autor:
Ingemar Björkhem, Ulf Diczfalusy, Anita Lövgren-Sandblom, Lena Starck, Monica Jonsson, Keri Tallman, Henrik Schirmer, Lilian Bomme Ousager, Peter J. Crick, Yuqin Wang, William J. Griffiths, F. Peter Guengerich
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 6, Pp 1165-1172 (2014)
A new mechanism for formation of 7-ketocholesterol was recently described involving cytochrome P-450 (CYP)7A1-catalyzed conversion of 7-dehydrocholesterol into 7-ketocholesterol with cholesterol-7,8-epoxide as a side product. Some patients with cereb
Externí odkaz:
https://doaj.org/article/576e66e606e24d37898877f880a7b361
Autor:
Ahmed Saeed, Federico Floris, Ulla Andersson, Irina Pikuleva, Anita Lövgren-Sandblom, Maria Bjerke, Martin Paucar, Anders Wallin, Per Svenningsson, Ingemar Björkhem
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 2, Pp 313-318 (2014)
There is a continuous flux of the oxysterol 27-hydroxycholesterol (27-OHC) from the circulation across the blood-brain barrier (BBB) into the brain. The major metabolite of 27-OHC in the brain is 7α-hydroxy-3-oxo-4-cholestenoic acid (7-HOCA). We con
Externí odkaz:
https://doaj.org/article/59a7314806d24d4a9fc206a8a02a6f57
Autor:
Zeina Ali, Maura Heverin, Maria Olin, Jure Acimovic, Anita Lövgren-Sandblom, Marjan Shafaati, Ann Båvner, Vardiella Meiner, Eran Leitersdorf, Ingemar Björkhem
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 4, Pp 1033-1043 (2013)
The two oxysterols, 27-hydroxycholesterol (27OH) and 24S-hydroxycholesterol (24OH), are both inhibitors of cholesterol synthesis and activators of the liver X receptor (LXR) in vitro. Their role as physiological regulators under in vivo conditions is
Externí odkaz:
https://doaj.org/article/3b238914b2e3482080eebfdfe6ed5a09
Autor:
Marjan Shafaati, Amelia Marutle, Hanna Pettersson, Anita Lövgren-Sandblom, Maria Olin, Irina Pikuleva, Bengt Winblad, Agneta Nordberg, Ingemar Björkhem
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 5, Pp 1004-1010 (2011)
There is a significant flux of the neurotoxic oxysterol 27-hydroxycholesterol (27OHC) from the circulation across the blood-brain barrier. Because there is a correlation between 27OHC and cholesterol in the circulation and lipoprotein-bound cholester
Externí odkaz:
https://doaj.org/article/e58aff6c3f8847e9b89bdf7500b05731
Autor:
Dragana D. Bojanic, Paul T. Tarr, Greg D. Gale, Desmond J. Smith, Dean Bok, Bryan Chen, Steven Nusinowitz, Anita Lövgren-Sandblom, Ingemar Björkhem, Peter A. Edwards
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 1, Pp 169-181 (2010)
ABCG1 and ABCG4 are highly homologous members of the ATP binding cassette (ABC) transporter family that regulate cellular cholesterol homeostasis. In adult mice, ABCG1 is known to be expressed in numerous cell types and tissues, whereas ABCG4 express
Externí odkaz:
https://doaj.org/article/1ce7609a1be94150831d0eb93a90f8c8
Autor:
Victoria Geenes, Anita Lövgren-Sandblom, Lisbet Benthin, Dominic Lawrance, Jenny Chambers, Vinita Gurung, Jim Thornton, Lucy Chappell, Erum Khan, Peter Dixon, Hanns-Ulrich Marschall, Catherine Williamson
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83828 (2014)
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder associated with an increased risk of adverse fetal outcomes. It is characterised by raised maternal serum bile acids, which are believed to cause the adverse outcomes.
Externí odkaz:
https://doaj.org/article/368cbbacdc92492694fcc577078aa6dd
Autor:
Anna Wuolikainen, Jure Acimovic, Anita Lövgren-Sandblom, Paolo Parini, Peter M Andersen, Ingemar Björkhem
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e113619 (2014)
High plasma levels of cholesterol have been suggested to be neuroprotective for the degenerative disease amyotrophic lateral sclerosis (ALS) and to be associated with increased survival time. The gene encoding cholesterol 27-hydroxylase, CYP27A1, was
Externí odkaz:
https://doaj.org/article/e6598c7ebb94454c83ee294f470972a6
Autor:
Jure Acimovic, Anita Lövgren-Sandblom, Maria Olin, Zeina Ali, Maura Heverin, Rebecca Schüle, Ludger Schöls, Björn Fischler, Peter Fickert, Michael Trauner, Ingemar Björkhem
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68031 (2013)
24S- and 27-hydroxycholesterol (24OHC and 27OHC) are potent regulators of different biochemical systems in vitro and are the major circulating oxysterols. A small fraction of these oxysterols has been reported to be sulphated but there are no detaile
Externí odkaz:
https://doaj.org/article/3a23f36d35224ac28d6a9da4fa331e2c
Autor:
Emanuele Porru, Erik Edström, Lisa Arvidsson, Adrian Elmi-Terander, Alexander Fletcher-Sandersjöö, Anita Lövgren Sandblom, Magnus Hansson, Frida Duell, Ingemar Björkhem
Publikováno v:
Brain Sciences, Vol 12, Iss 11, p 1450 (2022)
Idiopathic normal pressure hydrocephalus (iNPH) is the most common form of hydrocephalus in the adult population, and is often treated with cerebrospinal fluid (CSF) drainage using a ventriculoperitoneal (VP) shunt. Symptoms of iNPH include gait impa
Externí odkaz:
https://doaj.org/article/61c367d9fb9949ba8ba68eaec67e7e71