Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Anita K. Costa"'
Autor:
James R. Trudell, Anita K. Costa
Publikováno v:
Environmental Health Perspectives
Hepatocyte monolayer cultures were exposed to 6000 ppm styrene vapor at 20%, 2%, or 1% O2 and assayed for signs of cell damage immediately following the 2-hr exposure and then 24 hr later. Oxygen concentrations were used that were previously shown to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e8fad114d9429fc9b0bebefb875fdf
http://europepmc.org/articles/PMC1567641
http://europepmc.org/articles/PMC1567641
Publikováno v:
Annals of the New York Academy of Sciences. 625
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b91cf4644ad9f44c5233ec3a0eb022
https://pubmed.ncbi.nlm.nih.gov/2058922
https://pubmed.ncbi.nlm.nih.gov/2058922
Autor:
James R. Trudell, Anita K. Costa
Publikováno v:
Experimental and Molecular Pathology. 50:183-192
The toxicity of carbon tetrachloride (CCl4) in monolayer cultures of primary hepatocytes was investigated at oxygen concentrations that prevail in the liver under conditions that range from normoxia to hypoxia: 0.5, 1, 2, and 20% O2. CCl4 was adminis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b85589792716bdad700106991cd2630
https://doi.org/10.1016/0014-4800(89)90029-4
https://doi.org/10.1016/0014-4800(89)90029-4
Publikováno v:
In Vitro Cellular & Developmental Biology. 23:501-506
Inasmuch as it is known that the toxicity of anesthetic agents is potentiated by hypoxia and that the reductive metabolism of these agents results in the formation of lipid hydroperoxides, we investigated the toxicity of hydroperoxides under low-oxyg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d1921de535cb9901e7ca0b351908124
https://doi.org/10.1007/bf02628420
https://doi.org/10.1007/bf02628420
Publikováno v:
Anesthesiology. 68:485-494
Hypoxia, phenobarbital induction, and halothane anesthesia have been implicated in the pathogenesis of hepatotoxicity in the rat model. However, a controversy exists over the role of halothane in liver injury; does it act by reducing hepatic blood fl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c55e7de6444a4d1da680ce25a4566755
https://doi.org/10.1097/00000542-198804000-00003
https://doi.org/10.1097/00000542-198804000-00003
Publikováno v:
Archives of Biochemistry and Biophysics. 251:514-524
Polycyclic aromatic hydrocarbons bind to a cytosolic receptor that translocates into the nucleus and induces the synthesis of mRNA for a subset of cytochrome P-450 isozymes. The failure to detect a "phenobarbital" receptor, however, suggests that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd3cfba11bf53f81c0c0b8cea31972d
https://doi.org/10.1016/0003-9861(86)90359-0
https://doi.org/10.1016/0003-9861(86)90359-0
Autor:
Kathryn M. Ivanetich, Anita K. Costa
Publikováno v:
Biochemical Pharmacology. 31:2093-2102
Cis- and trans-1,1-dichloroethylene bound to the active site of hepatic microsomal cytochrome P-450 with the production of a Type I difference spectrum and stimulated CO-inhibitable hepatic microsomal NADPH oxidation. Incubation of cis- and trans-1,2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f913a53a7d31833a856485cb062d61f
https://doi.org/10.1016/0006-2952(82)90426-9
https://doi.org/10.1016/0006-2952(82)90426-9
Autor:
Anita K. Costa, Kathryn M. Ivanetich
Publikováno v:
Biochemical Pharmacology. 29:2863-2869
The interaction of tetrachloroethylene with hepatic microsomal cytochromes P-450 has been investigated using male Long-Evans rats. The spectral binding of tetrachloroethylene to cytochromes P-450 in hepatic microsomes from uninduced rats was characte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5585c47086b4713c3d40534a6c953ca6
https://doi.org/10.1016/0006-2952(80)90023-4
https://doi.org/10.1016/0006-2952(80)90023-4
Publikováno v:
Toxicology and applied pharmacology. 87(1)
Increased cytoplasmic calcium has been implicated in hepatic necrosis induced by cytochrome P-450-mediated halocarbon metabolism; hepatic necrosis is exacerbated by hypoxia. It is known that addition of the calcium ionophore A23187 to a cell can mimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a96e744feadf3ec51ce733245b0c93
https://pubmed.ncbi.nlm.nih.gov/3099427
https://pubmed.ncbi.nlm.nih.gov/3099427
Publikováno v:
Biochimica et biophysica acta. 878(2)
Leukotriene B 4 was found to be metabolized by rat hepatocyte monolayers at a rate that was linear with increasing substrate concentration from 74 to 740 nM leukotriene B 4 . The rates of metabolism were dependent on the O 2 concentration and were 31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2acf6f1b145b1cc82095682d3a2ca18
https://pubmed.ncbi.nlm.nih.gov/3019410
https://pubmed.ncbi.nlm.nih.gov/3019410