Výsledky vyhledávání - "Anita Ivanova"

Improving the enantioselectivity of artificial transfer hydrogenases based on the biotin–streptavidin technology by combinations of point mutations

Autor: Anita Ivanova, Christophe Letondor, Anca Pordea, Thomas R. Ward, Marc Creus

Publikováno v: Inorganica Chimica Acta. 363:601-604

Artificial metalloenzymes based on the incorporation of biotinylated ruthenium piano–stool complexes within streptavidin can be readily optimized by chemical or genetic means. We performed genetic modifications of such artificial metalloenzymes for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d37eccfa02aa47b7ea1306f672666d51
https://doi.org/10.1016/j.ica.2009.02.001

Zobrazit plný text záznamu

X-Ray Structure and Designed Evolution of an Artificial Transfer Hydrogenase

Autor: Anca Pordea, Christophe Letondor, Isolde LeTrong, Thomas R. Ward, Marc Creus, Thibaud Rossel, Alessia Sardo, Anita Ivanova, Ronald E. Stenkamp

Publikováno v: Angewandte Chemie International Edition. 47:1400-1404

A structure is worth a thousand words: guided by the crystal structure of an S-selective artificial transfer hydrogenase, designed evolution was used to optimize the selectivity of hybrid catalysts. Fine-tuning of the second coordination sphere of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13934e2a195997a556685ab6aae8f09b
https://doi.org/10.1002/anie.200704865

Zobrazit plný text záznamu

Artificial Metalloenzymes for Asymmetric Allylic Alkylation on the Basis of the Biotin–Avidin Technology

Autor: Anita Ivanova, Thomas R. Ward, Marc Creus, Julien Pierron, Julieta Gradinaru, Ines Hafner, Christophe Malan, Alessia Sardo

Publikováno v: Angewandte Chemie International Edition. 47:701-705

Palladium in the active site: The incorporation of a biotinylated palladium diphosphine within streptavidin yielded an artificial metalloenzyme for the title reaction (see scheme). Chemogenetic optimization of the catalyst by the introduction of a sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7457ca68d85fa77cadca763e5ec744ed
https://doi.org/10.1002/anie.200703159

Zobrazit plný text záznamu

Tailoring the Active Site of Chemzymes by Using a Chemogenetic-Optimization Procedure: Towards Substrate-Specific Artificial Hydrogenases Based on the Biotin-Avidin Technology

Autor: Julieta Gradinaru, Thomas R. Ward, Anita Ivanova, Gérard Klein, François Gilardoni, Untung E. Rusbandi, Nicolas Humbert

Publikováno v: Angewandte Chemie. 117:7942-7945

The combination of chemical- with genetic-optimization strategies (i.e. chemogenetic) allows the production of artificial hydrogenases based on the biotin–avidin technology. In the spirit of enzymes, second-coordination-sphere interactions between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ca009a24b2c35e923eb46238b8e3dac
https://doi.org/10.1002/ange.200502000

Zobrazit plný text záznamu

Artificial transfer hydrogenases based on the biotin-(strept)avidin technology: fine tuning the selectivity by saturation mutagenesis of the host protein

Autor: Thomas R. Ward, Anca Pordea, Sylwester Mazurek, Christophe Letondor, Nicolas Humbert, Marjana Novic, Anita Ivanova

Publikováno v: Journal of the American Chemical Society. 128(25)

Incorporation of biotinylated racemic three-legged d6-piano stool complexes in streptavidin yields enantioselective transfer hydrogenation artificial metalloenzymes for the reduction of ketones. Having identified the most promising organometallic cat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aac4cc31aee1f7d99780ef77f0226e7
https://pubmed.ncbi.nlm.nih.gov/16787096

Zobrazit plný text záznamu

Chemical Optimization of Artificial Metalloenzymes Based on the Biotin-Avidin Technology: (S)-Selective and Solvent-Tolerant Hydrogenation Catalysts via the Introduction of Chiral Amino Acid Spacers

Autor: Christophe Malan, Anita Ivanova, Myriem Skander, Thomas R. Ward

Publikováno v: ChemInform. 37

Incorporation of biotinylated-[rhodium(diphosphine)]+ complexes, with enantiopure amino acid spacers, in streptavidin affords solvent-tolerant and selective artificial metalloenzymes: up to 91% ee (S) in the hydrogenation of N-protected dehydroamino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50973ffe74b63c787e7dadcaab85f270
https://doi.org/10.1002/chin.200608167

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání