Zobrazeno 1 - 10
of 524
pro vyhledávání: '"Anita Ignatius"'
Autor:
Laura J. Brylka, Assil-Ramin Alimy, Miriam E. A. Tschaffon-Müller, Shan Jiang, Tobias Malte Ballhause, Anke Baranowsky, Simon von Kroge, Julian Delsmann, Eva Pawlus, Kian Eghbalian, Klaus Püschel, Astrid Schoppa, Melanie Haffner-Luntzer, David J. Beech, Frank Timo Beil, Michael Amling, Johannes Keller, Anita Ignatius, Timur A. Yorgan, Tim Rolvien, Thorsten Schinke
Publikováno v:
Bone Research, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Piezo proteins are mechanically activated ion channels, which are required for mechanosensing functions in a variety of cell types. While we and others have previously demonstrated that the expression of Piezo1 in osteoblast lineage cells is
Externí odkaz:
https://doaj.org/article/a1586c2aa5be4762bf608a21489eff44
Publikováno v:
Cellular & Molecular Biology Letters, Vol 28, Iss 1, Pp 1-41 (2023)
Abstract During aging and after traumatic injuries, cartilage and bone cells are exposed to various pathophysiologic mediators, including reactive oxygen species (ROS), damage-associated molecular patterns, and proinflammatory cytokines. This detrime
Externí odkaz:
https://doaj.org/article/c8345475004e422387422340901ddea1
Autor:
Miriam E. A. Tschaffon-Müller, Elena Kempter, Lena Steppe, Sandra Kupfer, Melanie R. Kuhn, Florian Gebhard, Carlos Pankratz, Miriam Kalbitz, Konrad Schütze, Harald Gündel, Nele Kaleck, Gudrun Strauß, Jean Vacher, Hiroshi Ichinose, Katja Weimer, Anita Ignatius, Melanie Haffner-Luntzer, Stefan O. Reber
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Mental traumatization is associated with long-bone growth retardation, osteoporosis and increased fracture risk. We revealed earlier that mental trauma disturbs cartilage-to-bone transition during bone growth and repair in mice. Trauma incre
Externí odkaz:
https://doaj.org/article/390d2eb5c5814de9a2dd67dbe9dd90a6
Autor:
Lena Steppe, Michael Megafu, Miriam E.A. Tschaffon-Müller, Anita Ignatius, Melanie Haffner-Luntzer
Publikováno v:
Bone Reports, Vol 19, Iss , Pp 101686- (2023)
Bone has the rare capability of scarless regeneration that enables the complete restoration of the injured bone area. In recent decades, promising new technologies have emerged from basic, translational and clinical research for fracture treatment; h
Externí odkaz:
https://doaj.org/article/f9289ee49c4a457f9e8db6195dbca09b
Autor:
Mubashir Ahmad, Nadine Stirmlinger, Irfana Jan, Ulrich Stifel, Sooyeon Lee, Marcel Weingandt, Ulrike Kelp, Jürgen Bockmann, Anita Ignatius, Tobias M. Böckers, Jan Tuckermann
Publikováno v:
JBMR Plus, Vol 7, Iss 2, Pp n/a-n/a (2023)
ABSTRACT Mutations of the postsynaptic scaffold protein Shank2 lead to autism spectrum disorders (ASD). These patients frequently suffer from higher fracture risk. Here, we investigated whether Shank2 directly regulates bone mass. We show that Shank2
Externí odkaz:
https://doaj.org/article/46146bcba9f2479d9d2e4235043799ce
Autor:
Mubashir Ahmad, Benjamin Thilo Krüger, Torsten Kroll, Sabine Vettorazzi, Ann-Kristin Dorn, Florian Mengele, Sooyeon Lee, Sayantan Nandi, Dilay Yilmaz, Miriam Stolz, Naveen Kumar Tangudu, David Carro Vázquez, Johanna Pachmayr, Ion Cristian Cirstea, Maja Vujic Spasic, Aspasia Ploubidou, Anita Ignatius, Jan Tuckermann
Publikováno v:
Bone Research, Vol 10, Iss 1, Pp 1-13 (2022)
Abstract Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis, a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblas
Externí odkaz:
https://doaj.org/article/5e25d23c32784b8db85ccc8f4edb0ce7
Autor:
Matthias Sukopp, Maoz Shemesh, Elena Pruech, Eran Linder‐Ganz, Scott Hacker, Vincenzo Condello, Jonas Schwer, Anita Ignatius, Lutz Dürselen, Andreas Martin Seitz
Publikováno v:
Journal of Experimental Orthopaedics, Vol 10, Iss 1, Pp n/a-n/a (2023)
Abstract Purpose The purpose of this in‐vitro study was to examine the kinematics of an artificial, free‐floating medial meniscus replacement device under dynamic loading situations and different knee joint states. Methods A dynamic knee simulato
Externí odkaz:
https://doaj.org/article/f17a31bbf6f54fb6be6bfc115355a307
Autor:
Melanie Haffner-Luntzer, Birte Weber, Kazuhito Morioka, Ina Lackner, Verena Fischer, Chelsea Bahney, Anita Ignatius, Miriam Kalbitz, Ralph Marcucio, Theodore Miclau
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionClinical and preclinical data suggest accelerated bone fracture healing in subjects with an additional traumatic brain injury (TBI). Mechanistically, altered metabolism and neuro-endocrine regulations have been shown to influence bone for
Externí odkaz:
https://doaj.org/article/8225009ee1cb423ca02c124f13c93b63
Autor:
Jasmin Maria Bülow, Nikolai Renz, Melanie Haffner-Luntzer, Verena Fischer, Astrid Schoppa, Jan Tuckermann, Jörg Köhl, Markus Huber-Lang, Anita Ignatius
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
In recent years, evidence has accumulated that the complement system, an integral part of innate immunity, may be involved in the regulation of bone homeostasis as well as inflammatory bone loss, for example, in rheumatoid arthritis and periodontitis
Externí odkaz:
https://doaj.org/article/e102d1ca34ac46c69bf8b674281a26d4
Autor:
Melanie R. Kuhn, Melanie Haffner-Luntzer, Elena Kempter, Stefan O. Reber, Hiroshi Ichinose, Jean Vacher, Anita Ignatius, Miriam E. A. Tschaffon-Müller
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Catecholamine signaling is known to influence bone tissue as reuptake of norepinephrine released from sympathetic nerves into bone cells declines with age leading to osteoporosis. Further, β-adrenoceptor-blockers like propranolol provoke osteoprotec
Externí odkaz:
https://doaj.org/article/c3f9b40511934696ae6cdb532a15acd1