Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Anita Hufnagel"'
Autor:
Madlen Meinert, Christina Jessen, Anita Hufnagel, Julia Katharina Charlotte Kreß, Mychal Burnworth, Theo Däubler, Till Gallasch, Thamara Nishida Xavier da Silva, Ancély Ferreira dos Santos, Carsten Patrick Ade, Werner Schmitz, Susanne Kneitz, José Pedro Friedmann Angeli, Svenja Meierjohann
Publikováno v:
Redox Biology, Vol 70, Iss , Pp 103011- (2024)
The cystine/glutamate antiporter xCT is an important source of cysteine for cancer cells. Once taken up, cystine is reduced to cysteine and serves as a building block for the synthesis of glutathione, which efficiently protects cells from oxidative d
Externí odkaz:
https://doaj.org/article/3fd2a9cca6cd42a59ae9cc508320c0e7
Autor:
Julia Katharina Charlotte Kreß, Christina Jessen, Anita Hufnagel, Werner Schmitz, Thamara Nishida Xavier da Silva, Ancély Ferreira dos Santos, Laura Mosteo, Colin R. Goding, José Pedro Friedmann Angeli, Svenja Meierjohann
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112724- (2023)
Summary: The redox regulator NRF2 becomes activated upon oxidative and electrophilic stress and orchestrates a response program associated with redox regulation, metabolism, tumor therapy resistance, and immune suppression. Here, we describe an unrec
Externí odkaz:
https://doaj.org/article/e9c771ed6d1c4e52a0f3a51015e08aa6
Autor:
Christina Jessen, Julia K. C. Kreß, Apoorva Baluapuri, Anita Hufnagel, Werner Schmitz, Susanne Kneitz, Sabine Roth, André Marquardt, Silke Appenzeller, Carsten P. Ade, Valerie Glutsch, Marion Wobser, José Pedro Friedmann-Angeli, Laura Mosteo, Colin R. Goding, Bastian Schilling, Eva Geissinger, Elmar Wolf, Svenja Meierjohann
Publikováno v:
Oncogene
The transcription factor NRF2 is the major mediator of oxidative stress responses and is closely connected to therapy resistance in tumors harboring activating mutations in the NRF2 pathway. In melanoma, such mutations are rare, and it is unclear to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693aa1dac27cf3feda7f718e6d7085e8
https://doi.org/10.1038/s41388-020-01477-8
https://doi.org/10.1038/s41388-020-01477-8
Autor:
Johannes, Grimm, Anita, Hufnagel, Marion, Wobser, Andreas, Borst, Sebastian, Haferkamp, Roland, Houben, Svenja, Meierjohann
Publikováno v:
Oncogenesis, Vol 7, Iss 9, Pp 1-12 (2018)
Approximately half of all melanoma patients harbour activating mutations in the serine/threonine kinase BRAF. This is the basis for one of the main treatment strategies for this tumor type, the targeted therapy with BRAF and MEK inhibitors. While the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ede739acd0939210141dbe9104082ee8
http://link.springer.com/article/10.1038/s41389-018-0082-2
http://link.springer.com/article/10.1038/s41389-018-0082-2
Autor:
Silke Appenzeller, Susanne Kneitz, Colin R. Goding, Svenja Meierjohann, Sabine Roth, Julia Katharina Charlotte Kreß, Carsten P. Ade, Valerie Glutsch, Apoorva Baluapuri, Werner Schmitz, Laura Mosteo, André Marquardt, Elmar Wolf, Eva Geissinger, Christina Jessen, José Pedro Friedmann-Angeli, Bastian Schilling, Anita Hufnagel, Marion Wobser
Publikováno v:
Oncogene. 40:1391-1391
The transcription factor NRF2 is the major mediator of oxidative stress responses and is closely connected to therapy resistance in tumors harboring activating mutations in the NRF2 pathway. In melanoma, such mutations are rare, and it is unclear to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f494abea5a4566f2eec7e3e506f17085
https://doi.org/10.1038/s41388-020-01535-1
https://doi.org/10.1038/s41388-020-01535-1
Autor:
Bastian Schilling, Roland Houben, Maria-Elisabeth Goebeler, Hermann Kneitz, Silke Appenzeller, Manfred Schartl, Matthias Goebeler, Anja Gesierich, Svenja Meierjohann, Katja Maurus, Alexander Thiem, Andreas Rosenwald, Andrea Gehrig, Simone Rost, Cornelia Schmidt, Vanessa Zirkenbach, Claudia Siedel, Thorsten Bischler, Anita Hufnagel, David Schrama, Ralf C. Bargou, Christina Jessen, Martina Regensburger
Publikováno v:
Cancer. 125(4)
Background Increasing knowledge of cancer genomes has triggered the development of specific targeted inhibitors, thus providing a valuable therapeutic pool. Methods In this report, the authors analyze the presence of targetable alterations in 136 tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3548850a2ec0509949dc972e389be078
https://pubmed.ncbi.nlm.nih.gov/30561760
https://pubmed.ncbi.nlm.nih.gov/30561760
Publikováno v:
Biochemical Journal. 471:267-279
Tumour cells are reported to display an imbalance in the levels of ROS (reactive oxygen species). Frequently, elevated ROS production goes along with compensatory up-regulation of antioxidant enzymes. Accordingly, we found in a previous study that pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa87a8abc593a11d051c1e3ed9bd79c6
https://doi.org/10.1042/bj20141204
https://doi.org/10.1042/bj20141204
Autor:
Johannes M. Haydn, Johannes Grimm, Katja Maurus, Manfred Schartl, Anita Hufnagel, Svenja Meierjohann
Publikováno v:
Oncotarget
Scopus-Elsevier
Scopus-Elsevier
// Johannes M. Haydn 1 , Anita Hufnagel 1 , Johannes Grimm 1 , Katja Maurus 1 , Manfred Schartl 1,2 and Svenja Meierjohann 1,2 1 Department of Physiological Chemistry, Biocenter, University of Wurzburg, Wurzburg, Germany 2 Comprehensive Cancer Center
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e230782acb21b8d2b2e6faa3079a56
http://europepmc.org/articles/PMC4148120
http://europepmc.org/articles/PMC4148120
Autor:
Svenja Meierjohann, Manfred Schartl, Christian Stigloher, Saskia A. Graf, Anita Hufnagel, Carola Berking, Eva Geissinger, F Geiger, Anja-Katrin Bosserhoff, Christoph Otto, A Heinemann, Annette Paschen, Katja Maurus, Susanne Kneitz
The MAPK pathway is activated in the majority of melanomas and is the target of therapeutic approaches. Under normal conditions, it initiates the so-called immediate early response, which encompasses the transient transcription of several genes belon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231e248ac64bbe9d00f111612fe930f9
https://www.ncbi.nlm.nih.gov/pubmed/28481878
https://www.ncbi.nlm.nih.gov/pubmed/28481878
Autor:
Martin Eilers, Svenja Meierjohann, M J Müller, Manfred Schartl, Susanne Kneitz, A Fekete, Anita Hufnagel, Susanne Walz, C Leikam
Publikováno v:
Oncogene. 33:771-782
The development of malignant melanoma is a highly complex process, which is still poorly understood. A majority of human melanomas are found to express a few oncogenic proteins, such as mutant RAS and BRAF variants. However, these oncogenes are also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab32efcf16664614ca544b7a30aade48
https://doi.org/10.1038/onc.2012.641
https://doi.org/10.1038/onc.2012.641