Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Anita Grigoriadis"'
Autor:
Hannah Si Hui Lau, Veronique Kiak Mien Tan, Benita Kiat Tee Tan, Yirong Sim, Jelmar Quist, Aye Aye Thike, Puay Hoon Tan, Shazib Pervaiz, Anita Grigoriadis, Kanaga Sabapathy
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-14 (2023)
Abstract Despite our understanding of the genetic basis of intra-tumoral heterogeneity, the role of stromal heterogeneity arising from an altered tumor microenvironment in affecting tumorigenesis is poorly understood. In particular, extensive study o
Externí odkaz:
https://doaj.org/article/482f96ed3bbe408b8d0cdb71f2bc3858
Autor:
Silvia Crescioli, Isabel Correa, Joseph Ng, Zena N. Willsmore, Roman Laddach, Alicia Chenoweth, Jitesh Chauhan, Ashley Di Meo, Alexander Stewart, Eleni Kalliolia, Elena Alberts, Rebecca Adams, Robert J. Harris, Silvia Mele, Giulia Pellizzari, Anna B. M. Black, Heather J. Bax, Anthony Cheung, Mano Nakamura, Ricarda M. Hoffmann, Manuela Terranova-Barberio, Niwa Ali, Ihor Batruch, Antoninus Soosaipillai, Ioannis Prassas, Antigona Ulndreaj, Miyo K. Chatanaka, Rosamund Nuamah, Shichina Kannambath, Pawan Dhami, Jenny L. C. Geh, Alastair D. MacKenzie Ross, Ciaran Healy, Anita Grigoriadis, David Kipling, Panagiotis Karagiannis, Deborah K. Dunn-Walters, Eleftherios P. Diamandis, Sophia Tsoka, James Spicer, Katie E. Lacy, Franca Fraternali, Sophia N. Karagiannis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract B cells are known to contribute to the anti-tumor immune response, especially in immunogenic tumors such as melanoma, yet humoral immunity has not been characterized in these cancers to detail. Here we show comprehensive phenotyping in sampl
Externí odkaz:
https://doaj.org/article/ec79417fc51f4749a49432bb35eb4eff
Autor:
Micaela Harrasser, Satyen Harish Gohil, Hiu Lau, Marco Della Peruta, Vincent Muczynski, Dominic Patel, Elena Miranda, Kristiana Grigoriadis, Anita Grigoriadis, David Granger, Rachel Evans, Amit Chunilal Nathwani
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-10 (2022)
Abstract Background Chimeric antigen receptor (CAR)-T cells can induce powerful immune responses in patients with hematological malignancies but have had limited success against solid tumors. This is in part due to the immunosuppressive tumor microen
Externí odkaz:
https://doaj.org/article/525e45b55e49442f8728048752ec16ba
Autor:
Fangfang Liu, Thomas Hardiman, Kailiang Wu, Jelmar Quist, Patrycja Gazinska, Tony Ng, Arnie Purushotham, Roberto Salgado, Xiaojing Guo, Sarah E. Pinder, Anita Grigoriadis
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract The level of stromal tumor-infiltrating lymphocytes (sTILs) in triple-negative (TNBC) and HER2-positive breast cancers convey prognostic information. The importance of systemic immunity to local immunity is unknown in breast cancer. We previ
Externí odkaz:
https://doaj.org/article/fa6779f79a31447c9a8b4c88579bba41
Autor:
Mengyuan Li, Angela Quintana, Elena Alberts, Miu Shing Hung, Victoire Boulat, Mercè Martí Ripoll, Anita Grigoriadis
Publikováno v:
Cancers, Vol 15, Iss 5, p 1517 (2023)
B cells have recently become a focus in breast cancer pathology due to their influence on tumour regression, prognosis, and response to treatment, besides their contribution to antigen presentation, immunoglobulin production, and regulation of adapti
Externí odkaz:
https://doaj.org/article/f6fc9d994a6646749340225e14df842a
Autor:
Patriek Jurrius, Thomas Green, Hans Garmo, Matthew Young, Massimiliano Cariati, Cheryl Gillett, Anca Mera, Mark Harries, Anita Grigoriadis, Sarah Pinder, Lars Holmberg, Arnie Purushotham
Publikováno v:
Breast, Vol 50, Iss , Pp 39-48 (2020)
Background: Major advances in breast cancer treatment have led to a reducuction in mortality. However, there are still women who are not cured. We hypothesize there is a sub-group of women with treatment-resistant cancers causing early death. Methods
Externí odkaz:
https://doaj.org/article/547d78fbf48c4294986e80fd5ffec387
Autor:
Isobelle Wall, Victoire Boulat, Aekta Shah, Kim R. M. Blenman, Yin Wu, Elena Alberts, Dinis Pedro Calado, Roberto Salgado, Anita Grigoriadis
Publikováno v:
Cancers, Vol 14, Iss 18, p 4505 (2022)
During the anti-tumour response to breast cancer, the primary tumour, the peripheral blood, and the lymph nodes each play unique roles. Immunological features at each site reveal evidence of continuous immune cross-talk between them before, during an
Externí odkaz:
https://doaj.org/article/af60730a0a0147a8af1810826d96e241
Autor:
Anthony Cheung, Alicia M. Chenoweth, Jelmar Quist, Heng Sheng Sow, Christina Malaktou, Riccardo Ferro, Ricarda M. Hoffmann, Gabriel Osborn, Eirini Sachouli, Elise French, Rebecca Marlow, Katie E. Lacy, Sophie Papa, Anita Grigoriadis, Sophia N. Karagiannis
Publikováno v:
Cancers, Vol 14, Iss 14, p 3361 (2022)
Triple-negative breast cancers (TNBC) expressing PD-L1 qualify for checkpoint inhibitor immunotherapy. Cyclin E/CDK2 is a potential target axis in TNBC; however, small-molecule drugs at efficacious doses may be associated with toxicity, and treatment
Externí odkaz:
https://doaj.org/article/b84d0e44fa5848bbab448af572e7d04e
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Lymph nodes (LNs) are highly organized secondary lymphoid organs, and reflective of immune responses to infection, injuries, or the presence of cancer. Extensive molecular and morphological analyses of immune and stromal features in tumors and LNs of
Externí odkaz:
https://doaj.org/article/d8ba58ccb7be404e90796f455f21bf48
Autor:
Aida Santaolalla, Hans Garmo, Anita Grigoriadis, Sundeep Ghuman, Niklas Hammar, Ingmar Jungner, Göran Walldius, Mats Lambe, Lars Holmberg, Mieke Van Hemelrijck
Publikováno v:
BMC Molecular and Cell Biology, Vol 20, Iss 1, Pp 1-15 (2019)
Abstract Background Metabolites are genetically and environmentally determined. Consequently, they can be used to characterize environmental exposures and reveal biochemical mechanisms that link exposure to disease. To explore disease susceptibility
Externí odkaz:
https://doaj.org/article/f1eb1c74b2d84ad5b3c0487a93c291af