Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Anita Goyala"'
Autor:
Alina C. Teuscher, Cyril Statzer, Anita Goyala, Seraina A. Domenig, Ingmar Schoen, Max Hess, Alexander M. Hofer, Andrea Fossati, Viola Vogel, Orcun Goksel, Ruedi Aebersold, Collin Y. Ewald
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Dysfunctional extracellular matrices (ECM) contribute to aging and disease. Repairing dysfunctional ECM could potentially prevent age-related pathologies. Interventions promoting longevity also impact ECM gene expression. However, the role o
Externí odkaz:
https://doaj.org/article/c0e058623cd74bde8b2a47d1ff75c848
Publikováno v:
eLife, Vol 12 (2023)
The amyloid beta (Aβ) plaques found in Alzheimer’s disease (AD) patients’ brains contain collagens and are embedded extracellularly. Several collagens have been proposed to influence Aβ aggregate formation, yet their role in clearance is unknow
Externí odkaz:
https://doaj.org/article/a453b4860a2b4ed9a190f65e2d2b127b
Autor:
Manish Chamoli, Anita Goyala, Syed Shamsh Tabrez, Atif Ahmed Siddiqui, Anupama Singh, Adam Antebi, Gordon J. Lithgow, Jennifer L. Watts, Arnab Mukhopadhyay
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Metabolic reprogramming during Dietary Restriction (DR) activates cytoprotective gene expression. Here the authors show that PUFAs generated during DR signal via the p38-MAPK pathway to enhance cytoprotective gene expression, contributing to increase
Externí odkaz:
https://doaj.org/article/3c37c1fd9a7048f1bb216609bd91f5e7
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0241478 (2020)
Dietary restriction (DR) increases life span and improves health in most model systems tested, including non-human primates. In C. elegans, as in other models, DR leads to reprogramming of metabolism, improvements in mitochondrial health, large chang
Externí odkaz:
https://doaj.org/article/baf16c2604454c29b37221181c239ae1
Publikováno v:
PLoS Genetics, Vol 14, Iss 8, p e1007608 (2018)
Diet profoundly affects metabolism and incidences of age-related diseases. Animals adapt their physiology to different food-types, modulating complex life-history traits like aging. The molecular mechanisms linking adaptive capacity to diet with agin
Externí odkaz:
https://doaj.org/article/b4f4b1287f45480b8e18250168391a2a
Autor:
Dominic F. Bennett, Anita Goyala, Cyril Statzer, Charles W. Beckett, Alexander Tyshkovskiy, Vadim N. Gladyshev, Collin Y. Ewald, João Pedro de Magalhães
Publikováno v:
Aging Cell, 22 (2)
Repurposing drugs capable of extending lifespan and health span has a huge untapped potential in translational geroscience. Here, we searched for known compounds that elicit a similar gene expression signature to caloric restriction and identified ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3fb8ec041bd04c6c0300179a963d583
https://hdl.handle.net/20.500.11850/596274
https://hdl.handle.net/20.500.11850/596274
Autor:
Alina C. Teuscher, Cyril Statzer, Anita Goyala, Seraina A. Domenig, Ingmar Schoen, Max Hess, Alexander M. Hofer, Andrea Fossati, Viola Vogel, Orcun Goksel, Ruedi Aebersold, Collin Y. Ewald
Although it is postulated that dysfunctional extracellular matrices (ECM) drive aging and disease, how ECM integrity assures longevity is unknown. Here, using proteomics and in-vivo monitoring of fluorescently tagged ECM proteins, we systematically e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ddfb76a940c2acacabf30383ddd6bc0
https://doi.org/10.1101/2022.08.30.505802
https://doi.org/10.1101/2022.08.30.505802
Autor:
Gautam Chandra Sarkar, Umanshi Rautela, Anita Goyala, Sudeshna Datta, Nikhita Anand, Anupama Singh, Prachi Singh, Manish Chamoli, Arnab Mukhopadhyay
Germline integrity is critical for progeny fitness. Organisms deploy the DNA damage response (DDR) signalling to protect germline from genotoxic stress, facilitating cell-cycle arrest of germ cells and DNA repair or their apoptosis. Cell-autonomous r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b566491eefeecfd1b48ddd88e3e79a
https://doi.org/10.21203/rs.3.rs-1119544/v1
https://doi.org/10.21203/rs.3.rs-1119544/v1
Autor:
Charles W. Beckett, Collin Y. Ewald, Alexander Tyshkovskiy, Anita Goyala, Vadim N. Gladyshev, Dominic Bennett, João Pedro de Magalhães, Cyril Statzer
Caloric restriction increases lifespan across species and has health benefits in humans. Because complying with a low-calorie diet is challenging, here we investigated pharmacological interventions mimicking the benefits of caloric restriction. Searc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e16aa8ae93391690f51eab03e0852c50
https://doi.org/10.1101/2021.10.13.464294
https://doi.org/10.1101/2021.10.13.464294
Autor:
Fabian Fischer, Christoph Benner, Anita Goyala, Giovanna Grigolon, Davide Vitiello, JiaYee Wu, Kim Zarse, Collin Y. Ewald, Michael Ristow
Publikováno v:
Journal of Biological Chemistry, 298 (7)
Inhibition of gene expression in Caenorhabditis elegans, a versatile model organism for studying the genetics of development and aging, is achievable by feeding nematodes with bacteria expressing specific dsRNAs. Overexpression of hypoxia-inducible f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e326c9c011cbdc49e0e81409d0c282
https://doi.org/10.1016/j.jbc.2022.102085
https://doi.org/10.1016/j.jbc.2022.102085