Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Anita Eckly"'
Autor:
Antoine Oprescu, Déborah Michel, Adrien Antkowiak, Elodie Vega, Julien Viaud, Sara A. Courtneidge, Anita Eckly, Henri de la Salle, Gaëtan Chicanne, Catherine Léon, Bernard Payrastre, Frédérique Gaits-Iacovoni
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Bone marrow megakaryocytes (MKs) undergo a maturation involving contacts with the microenvironment before extending proplatelets through sinusoids to deliver platelets in the bloodstream. We demonstrated that MKs assemble linear F-actin-enri
Externí odkaz:
https://doaj.org/article/3c534a032d894f3da7e0844798600b5c
Autor:
Robert H. Lee, Dorsaf Ghalloussi, Gabriel L. Harousseau, Joseph P. Kenny, Patrick A. Kramer, Fabienne Proamer, Bernhard Nieswandt, Matthew J. Flick, Christian Gachet, Caterina Casari, Anita Eckly, Wolfgang Bergmeier
Publikováno v:
JCI Insight, Vol 7, Iss 8 (2022)
Platelet homeostasis is dependent on a tight regulation of both platelet production and clearance. The small GTPase Rap1 mediates platelet adhesion and hemostatic plug formation. However, Rap1 signaling is also critical for platelet homeostasis as bo
Externí odkaz:
https://doaj.org/article/2186e8e3188e42de854d0ccf9a4a23a7
Autor:
Cyril Scandola, Mathieu Erhardt, Jean-Yves Rinckel, Fabienne Proamer, Christian Gachet, Anita Eckly
Publikováno v:
Platelets, Vol 31, Iss 5, Pp 589-598 (2020)
Electron microscopy (EM) has a long history in megakaryocyte (MK) cellular biology. This chapter shows how the electron microscope, since its first appearance almost 90 years ago, has occupied center stage in the studies of MK morphology and function
Externí odkaz:
https://doaj.org/article/fa54f38a50e14b71981c6de83cf40757
Autor:
Nilda Vanesa Ayala-Nunez, Gautier Follain, François Delalande, Aurélie Hirschler, Emma Partiot, Gillian L. Hale, Brigid C. Bollweg, Judith Roels, Maxime Chazal, Florian Bakoa, Margot Carocci, Sandrine Bourdoulous, Orestis Faklaris, Sherif R. Zaki, Anita Eckly, Béatrice Uring-Lambert, Frédéric Doussau, Sarah Cianferani, Christine Carapito, Frank M. J. Jacobs, Nolwenn Jouvenet, Jacky G. Goetz, Raphael Gaudin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Zika virus (ZIKV) can infect the central nervous system, but it is not clear how it reaches the brain. Here, Ayala-Nunez et al. show in ex vivo and in vivo models that ZIKV can hitch a ride in monocytes in a Trojan Horse manner to cross the endotheli
Externí odkaz:
https://doaj.org/article/80c8125c989f4ad684da8d5bd8592317
Autor:
Alicia Aguilar, Josiane Weber, Julie Boscher, Monique Freund, Catherine Ziessel, Anita Eckly, Stéphanie Magnenat, Catherine Bourdon, Béatrice Hechler, Pierre H. Mangin, Christian Gachet, François Lanza, Catherine Léon
Publikováno v:
Blood Advances, Vol 3, Iss 15, Pp 2368-2380 (2019)
Abstract: The biogenesis of lysosome related organelles is defective in Hermansky-Pudlak syndrome (HPS), a disorder characterized by oculocutaneous albinism and platelet dense granule (DG) defects. The first animal model of HPS was the fawn-hooded ra
Externí odkaz:
https://doaj.org/article/f9d29b63529c4e02b39d934bab4263b3
Autor:
Alicia Bornert, Julie Boscher, Fabien Pertuy, Anita Eckly, David Stegner, Catherine Strassel, Christian Gachet, François Lanza, Catherine Léon
Publikováno v:
Haematologica, Vol 106, Iss 5 (2020)
Platelets are produced by bone marrow megakaryocytes through cytoplasmic protrusions, named native proplatelets (nPPT), into blood vessels. Proplatelets also refer to protrusions observed in megakaryocyte culture (cPPT) that are morphologically diffe
Externí odkaz:
https://doaj.org/article/9293cffb03a54b7689d117281a64e7d2
Autor:
Timo Vögtle, Sumana Sharma, Jun Mori, Zoltan Nagy, Daniela Semeniak, Cyril Scandola, Mitchell J Geer, Christopher W Smith, Jordan Lane, Scott Pollack, Riitta Lassila, Annukka Jouppila, Alastair J Barr, Derek J Ogg, Tina D Howard, Helen J McMiken, Juli Warwicker, Catherine Geh, Rachel Rowlinson, W Mark Abbott, Anita Eckly, Harald Schulze, Gavin J Wright, Alexandra Mazharian, Klaus Fütterer, Sundaresan Rajesh, Michael R Douglas, Yotis A Senis
Publikováno v:
eLife, Vol 8 (2019)
The immunoreceptor tyrosine-based inhibition motif (ITIM)-containing receptor G6b-B is critical for platelet production and activation. Loss of G6b-B results in severe macrothrombocytopenia, myelofibrosis and aberrant platelet function in mice and hu
Externí odkaz:
https://doaj.org/article/c344e049fe504f759f1164a922d96039
Autor:
Tatiana A. Kovalenko, Marie-Noelle Giraud, Anita Eckly, Anne-Sophie Ribba, Fabienne Proamer, Sandrine Fraboulet, Nadezhda A. Podoplelova, Jeremy Valentin, Mikhail A. Panteleev, Carmen Gonelle-Gispert, Stéphane Cook, Laurence Lafanechère, Anastasia N. Sveshnikova, Karin Sadoul
Publikováno v:
Cells, Vol 10, Iss 3, p 584 (2021)
Primary hemostasis consists in the activation of platelets, which spread on the exposed extracellular matrix at the injured vessel surface. Secondary hemostasis, the coagulation cascade, generates a fibrin clot in which activated platelets and other
Externí odkaz:
https://doaj.org/article/63aa568d6dfd4a708ae21e1b3a54deb0
Autor:
Paul Saultier, Léa Vidal, Matthias Canault, Denis Bernot, Céline Falaise, Catherine Pouymayou, Jean-Claude Bordet, Noémie Saut, Agathe Rostan, Véronique Baccini, Franck Peiretti, Marie Favier, Pauline Lucca, Jean-François Deleuze, Robert Olaso, Anne Boland, Pierre Emmanuel Morange, Christian Gachet, Fabrice Malergue, Sixtine Fauré, Anita Eckly, David-Alexandre Trégouët, Marjorie Poggi, Marie-Christine Alessi
Publikováno v:
Haematologica, Vol 102, Iss 6 (2017)
Congenital macrothrombocytopenia is a family of rare diseases, of which a significant fraction remains to be genetically characterized. To analyze cases of unexplained thrombocytopenia, 27 individuals from a patient cohort of the Bleeding and Thrombo
Externí odkaz:
https://doaj.org/article/76deb145087e480181da79022f102298
Autor:
Olga G Cordeiro, Mélanie Chypre, Nathalie Brouard, Simon Rauber, Farouk Alloush, Monica Romera-Hernandez, Cécile Bénézech, Zhi Li, Anita Eckly, Mark C Coles, Antal Rot, Hideo Yagita, Catherine Léon, Burkhard Ludewig, Tom Cupedo, François Lanza, Christopher G Mueller
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151848 (2016)
Microenvironment and activation signals likely imprint heterogeneity in the lymphatic endothelial cell (LEC) population. Particularly LECs of secondary lymphoid organs are exposed to different cell types and immune stimuli. However, our understanding
Externí odkaz:
https://doaj.org/article/c21c765901a640338c1658927286699d