Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Anita C. Rudy"'
Publikováno v:
The Journal of Pain. 11:24-31
We conducted a prospective multicenter, open-label, escalating dose-range trial to compare, across patients, single intranasal doses (2, 4, 6, 8, and 10 mg) of hydromorphone HCl in the treatment of acute trauma pain The main outcome measure of pain-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5af37efb70caa3c29b8293a7ee6a470
https://doi.org/10.1016/j.jpain.2009.05.002
https://doi.org/10.1016/j.jpain.2009.05.002
Publikováno v:
Epilepsy Research. 83:124-132
Summary Purpose To compare 2.5mg and 5.0mg single-dose pharmacokinetics (PK), pharmacodynamics (PD) and tolerability of an intranasal (IN) midazolam formulation, to a 2.5-mg intravenous (IV) dose. Methods Design was an open-label, three-way crossover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b64b5db659d4e03dd14c219cb8c3cb
https://doi.org/10.1016/j.eplepsyres.2008.10.005
https://doi.org/10.1016/j.eplepsyres.2008.10.005
Publikováno v:
Clinical Therapeutics. 27:430-440
Butorphanol tartrate (BT) nasal spray is currently marketed as a multidose spray pump product. However, access to excessive amounts of drug in a single bottle (up to 15 doses) creates the potential for misuse, diversion, and abuse.This study evaluate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e093ed830483f1419fa10ef7e6ee36
https://doi.org/10.1016/j.clinthera.2005.04.002
https://doi.org/10.1016/j.clinthera.2005.04.002
Publikováno v:
Clinical Drug Investigation. 24:633-639
Narcotic analgesics such as hydromorphone undergo an extensive first-pass effect resulting in a low systemic bioavailability following oral administration. Alternative dosing routes, such as rectal and intranasal (IN) routes, have been suggested as o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b033320297ba03ea9c50d0f77fccda
https://doi.org/10.2165/00044011-200424110-00002
https://doi.org/10.2165/00044011-200424110-00002
Publikováno v:
Pharmacotherapy. 24:26-32
Study Objective. To investigate the effect of the nasal corticosteroid fluticasone propionate on the bioavailability and pharmacokinetics of single-dose intranasal hydromorphone hydrochloride in patients with allergic rhinitis. Design. Randomized, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f620be3740e94be62cb8deaa6f6ac0cd
https://doi.org/10.1592/phco.24.1.26.34810
https://doi.org/10.1592/phco.24.1.26.34810
Publikováno v:
Pharmacotherapy. 23:153-158
Study Objectives. To determine the distribution of hydromorphone into breast milk and the potential exposure of the suckling infant, and whether the distribution of hydromorphone into milk can be predicted accurately by a passive diffusion model. Des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7142477bff7fff832a549e7ffa332d
https://doi.org/10.1592/phco.23.2.153.32081
https://doi.org/10.1592/phco.23.2.153.32081
Publikováno v:
The Journal of Clinical Pharmacology. 41:1225-1231
The purpose of this study was to evaluate the pharmacokinetic profile of intranasal lorazepam in comparison to currently established administration routes. Eleven healthy volunteers completed this randomized crossover study. On three occasions, each
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d2319ddc62211241cc803795a7e9e7
https://doi.org/10.1177/00912700122012779
https://doi.org/10.1177/00912700122012779
Publikováno v:
British Journal of Clinical Pharmacology. 37:1-5
1. Piroxicam pharmacokinetics were assessed in three groups of subjects: (1) young healthy volunteers, (2) healthy elderly subjects (mean +/- s.d. creatinine clearance 88 +/- 13 ml min-1), and (3) elderly patients with renal insufficiency (creatinine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcbaafb1427ac1df9b6ecb8e9bf74898
https://doi.org/10.1111/j.1365-2125.1994.tb04230.x
https://doi.org/10.1111/j.1365-2125.1994.tb04230.x
Autor:
Qian Xiaotao, Anita C. Rudy, Stephen D. Hall, Sarah I. Ryan, Lorrie A. Kalasinski, John D. Bradley
Publikováno v:
Therapeutic Drug Monitoring. 14:464-470
The pharmacokinetics of the enantiomers of ibuprofen have been investigated following oral administration of 300 or 600 mg of racemic ibuprofen four times daily to 45 patients with osteoarthritis. Fifteen of these patients also received single doses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c66942fe0dcf51d7edad323f17ac45bc
https://doi.org/10.1097/00007691-199212000-00005
https://doi.org/10.1097/00007691-199212000-00005
Publikováno v:
Pharmacotherapy. 28(7)
Study Objective. To evaluate the pharmacokinetics of haloperidol after intranasal administration compared with intravenous and intramuscular administration, and to evaluate systemic and local tolerance of intranasal administration. Design. Randomized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ea60741cd1a407c86ec27aa7b78dbe
https://pubmed.ncbi.nlm.nih.gov/18576902
https://pubmed.ncbi.nlm.nih.gov/18576902