Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Anita Bułakowska"'
Autor:
Rafał Hałasa, Anita Bułakowska, Jarosław Sławiński, Magdalena Smoktunowicz, Aleksandra Rapacka-Zdończyk, Urszula Mizerska
Publikováno v:
Antibiotics, Vol 12, Iss 12, p 1691 (2023)
The rapid increase in strains that are resistant to antibiotics requires new active compounds to be found whose mechanism of action on bacteria is different to those that are currently known. Of particular interest are compounds that occur in plants
Externí odkaz:
https://doaj.org/article/230f736b70b6420ab58ea69fab192813
Autor:
Anita Bułakowska, Jarosław Sławiński, Anna Hering, Magdalena Gucwa, J. Renata Ochocka, Rafał Hałasa, Łukasz Balewski, Justyna Stefanowicz-Hajduk
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 274 (2023)
Chalcones and their derivatives, both natural and synthetic, exhibit diverse biological activities. In this study, we focused on designing and synthesizing (E)-2,4-dichloro-N-(4-cinnamoylphenyl)-5-methylbenzenesulfonamides 4–8 with the following tw
Externí odkaz:
https://doaj.org/article/f4254283b59547519a55c9b52e631595
Autor:
Anita Bułakowska, Jarosław Sławiński, Rafał Hałasa, Anna Hering, Magdalena Gucwa, J. Renata Ochocka, Justyna Stefanowicz-Hajduk
Publikováno v:
Molecules, Vol 28, Iss 7, p 3087 (2023)
Cinnamic acid is a plant metabolite with antimicrobial, anticancer, and antioxidant properties. Its synthetic derivatives are often more effective in vitro than parent compounds due to stronger biological activities. In our study, we synthesized ten
Externí odkaz:
https://doaj.org/article/f2129ac5a5d248e99b3a47b0778bc884
Publikováno v:
Medical Sciences Forum, Vol 14, Iss 1, p 55 (2022)
Aryl/heteroarylsulfonamides are an important group of compounds with different directions of biological activity. The number of literature reports on the antibacterial activity of sulfonamides is steadily increasing, bringing a lot of interesting dat
Externí odkaz:
https://doaj.org/article/6883aa76e4754b75afeac6b09048c726
Autor:
Grzegorz Stasiłojć, Marcin Serocki, Mateusz Heldt, Jarosław Sławiński, Anita Bułakowska, Kamila Siedlecka-Kroplewska
Publikováno v:
Bioorganic Chemistry. 104:104309
A new series of N-(aryl/heteroaryl)-2-chlorobenzenesulfonamide derivatives 4-21 have been synthesized, and evaluated at the National Cancer Institute (USA) for their in vitro activities against a panel of 60 different human cancer cell lines. Among t
Autor:
Anita Bułakowska, Marek T. Konieczny
Publikováno v:
Journal of Heterocyclic Chemistry. 52:440-444
A new, mild method of synthesis of 2-hydroxyphenyl vinyl sulfones from 4,4-dioxo-2,3-dihydrobenzo[b][1,4]oxathiine derivatives is described. The products were further modified in situ, either by Michael addition of nucleophiles or by reaction of the
Publikováno v:
Mycoses. 54:e407-e414
AMG-148, pochodna chalkonu z pierścieniem oksatiolonowym, wykazuje aktywnośc przeciwgrzybową in vitro wobec szczepow grzybowych patogennych dla czlowieka, z wartościami minimalnych stezen hamujących wzrost mieszczących sie w zakresie 1-16 mikro
Autor:
Marek T. Konieczny, Anita Bułakowska
Publikováno v:
ChemInform. 46
A new, mild method of synthesis of 2-hydroxyphenyl vinyl sulfones from 4,4-dioxo-2,3-dihydrobenzo[b][1,4]oxathiine derivatives is described. The products were further modified in situ, either by Michael addition of nucleophiles or by reaction of the
Publikováno v:
Journal of Heterocyclic Chemistry. 39:911-915
The ureidation reactions of 2- and 4-picoline N-oxides with 2-chloro-4,5-dihydroimidazole are described. A mechanism of novel thioureidation reaction of 4-picoline N-oxide with 2-(4,5-dihydro-1H-imidazol-2-ylthioxy)-4,5-dihydro-1H-imidazole is propos
Autor:
Wojciech Konieczny, Michal Sabisz, Justyna Polak, Joanna Wietrzyk, Patrycja Gryń, Marek T. Konieczny, Katarzyna Wiciejowska, Krzysztof Lemke, Andrzej Skladanowski, Marlena Gałązka, Danuta Pirska, Anna Pieczykolan, Anita Bułakowska
Publikováno v:
Chemical biologydrug design. 84(1)
Derivatives of (E)-1-(5-alkoxybenzo[d][1,3]oxathiol-6-yl)-3-phenylprop-2-en-1-one (1) demonstrated exceptionally high in vitro cytotoxic activity, with IC50 values of the most active derivatives in the nanomolar range. To identify structural fragment