Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Anita Bartoszko-Malik"'
Autor:
Peter F. Kador, Anita Bartoszko-Malik, Duane D. Miller, Yasar S. Abdel‐Ghany, Tadashi Mizoguchi, Isaac O. Donkor
Publikováno v:
European Journal of Medicinal Chemistry. 34:235-243
Derivatives of alrestatin ( 1 – 5 ) and alconil ( 6 – 8 ) possessing Michael acceptor substituents were synthesized as aldose reductase inhibitors. The alrestatin derivatives demonstrated enhanced aldose reductase inhibitory activity. The most po
Autor:
Isaac O. Donkor, Yasser S. Abdel-Ghany, Duane D. Miller, Peter F. Kador, Anita Bartoszko-Malik, Tadashi Mizoguchi
Publikováno v:
European Journal of Medicinal Chemistry. 33:15-22
We have synthesized alrestatin derivatives 1–11 possessing acyl benzenesulfonamide groups as surrogates for the carboxylic acid moiety of alrestatin. Most of the compounds were inactive as aldose reductase inhibitors compared to alrestatin, however
Autor:
Frank McKinney, Jason Kim, Mihaela Draganoiu Leonida, Susan B. Sobolov, Kamen I. Voivodov, Albert J. Fry, Anita Bartoszko-Malik
Publikováno v:
The Journal of Organic Chemistry. 61:2125-2128
Lactate dehydrogenase (LDH) was crystallized from concentrated ammonium sulfate solution and cross-linked with glutaraldehyde to afford long-lived enzymatically active cross-linked crystals (LDH-CLC). The crystals were employed in an electrolytic cel
Publikováno v:
Tetrahedron Letters. 35:7751-7754
Crystals of rabbit muscle aldolase were grown from 45% saturated ammonium sulfate solutions and cross-linked with glutaraldehyde to produce a biocatalyst that has stability for months, can be reisolated and reused, and has excellent solvent stability
Autor:
Peter F. Kador, Yasser S. Abdel-Ghany, Duane D. Miller, Isaac O. Donkor, Anita Bartoszko-Malik, Tadashi Mizoguchi
Publikováno v:
ChemInform. 29
We have synthesized alrestatin derivatives 1–11 possessing acyl benzenesulfonamide groups as surrogates for the carboxylic acid moiety of alrestatin. Most of the compounds were inactive as aldose reductase inhibitors compared to alrestatin, however
Autor:
Anita Bartoszko-Malik, Duane D. Miller, Yasar S. Abdel‐Ghany, Tadashi Mizoguchi, Isaac O. Donkor, Peter F. Kador
Publikováno v:
ChemInform. 30
Derivatives of alrestatin ( 1 – 5 ) and alconil ( 6 – 8 ) possessing Michael acceptor substituents were synthesized as aldose reductase inhibitors. The alrestatin derivatives demonstrated enhanced aldose reductase inhibitory activity. The most po
Publikováno v:
The American journal of physiology. 274(6)
Although bile acids damage gastric mucosa, the mechanisms underlying tissue injury induced by these agents are not well understood. To determine whether bile acids alter gastric secretory function, we investigated the actions of sodium cholate, deoxy
Autor:
Sanai Sato, Peter F. Kador, Duane D. Miller, Anita Bartoszko-Malik, Yong S. Lee, Libaniel Rodriguez, Yasser S. Abdel-Ghany
Publikováno v:
Bioorganicmedicinal chemistry. 3(10)
Animal studies indicate that aldose reductase inhibitors represent a pharmacological method for inhibiting the onset of diabetic complications that is independent of blood sugar control. This has spurred the development of aldose reductase inhibitors