Zobrazeno 1 - 10
of 299
pro vyhledávání: '"Anita B. Roberts"'
Publikováno v:
BioTechniques, Vol 43, Iss 3, Pp 289-294 (2007)
Canonical TGF-β is involved in cell differentiation, tissue maintenance, and wound healing, but also plays a central role in the pathogenesis of diseases such as cancer. Here we describe a lentivirus-based reporter vector system expressing green flu
Externí odkaz:
https://doaj.org/article/a1b3e2a71f0b4b798fc67d9f9e6791aa
Autor:
Anita B. Roberts, Hector F. DeLuca
Publikováno v:
Journal of Lipid Research, Vol 9, Iss 4, Pp 501-508 (1968)
Liver and kidney microsomes have been found to catalyze a rapid decarboxylation of retinoic acid in vitro. The reaction requires NADPH and Fe2+, and is further stimulated by the presence of pyrophosphate. Thiamine pyrophosphate contained sufficient i
Externí odkaz:
https://doaj.org/article/1ae038d8733640faa4b8c5b4e73a98be
Autor:
Christina H Stuelten, Johanna I Busch, Binwu Tang, Kathleen C Flanders, Akira Oshima, Emily Sutton, Tatiana S Karpova, Anita B Roberts, Lalage M Wakefield, John E Niederhuber
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9832 (2010)
Carcinoma are complex societies of mutually interacting cells in which there is a progressive failure of normal homeostatic mechanisms, causing the parenchymal component to expand inappropriately and ultimately to disseminate to distant sites. When a
Externí odkaz:
https://doaj.org/article/d15b19825f5f427fac40762a3c937a65
Autor:
David C. Beebe, Ramya Rajagopal, Vesa Kaartinen, Jie Huang, Anita B. Roberts, Lieve Umans, Chu-Xia Deng, Lisa K. Dattilo, Yuji Mishina, An Zwijsen, Ying Liu
Publikováno v:
Development. 136:1741-1750
There are conflicting reports about whether BMP signaling is required for eyelid closure during fetal development. This question was addressed using mice deficient in BMP or TGFβ signaling in prospective eyelid and conjunctival epithelial cells. Gen
Autor:
David M. Harlan, Seong-Jin Kim, Heather W. Collins, Anil K. Kamaraju, Huei-Min Lin, Franz M. Matschinsky, Duan Zhigang, Sushil G. Rane, Hariom Yadav, Eric Liu, Anita B. Roberts, Ji-Hyeon Lee, Anthony Vieira
Publikováno v:
Journal of Biological Chemistry. 284:12246-12257
Pancreatic islet beta-cell dysfunction is a signature feature of Type 2 diabetes pathogenesis. Consequently, knowledge of signals that regulate beta-cell function is of immense clinical relevance. Transforming growth factor (TGF)-beta signaling plays
Autor:
Ryan Katz, Lalage M. Wakefield, Misako Sato, Anita B. Roberts, Christina H. Stuelten, Adrian Barbul, Emily Sutton, John E. Niederhuber, Johanna Busch
Publikováno v:
Cancer Research. 68:7278-7282
We investigated the influence of acute wounding on tumor growth in a syngeneic mouse breast cancer model. Metastatic mouse breast cancer cells (4T1) were orthotopically injected into the mammary fat pads of BALB/c mice, and animals were wounded local
Publikováno v:
Oncogene. 27:2507-2512
The ability of transforming growth factor-beta (TGF-beta) to modulate various effects on distinct cell lineages has been a central feature of its multi-faceted nature. The purpose of this study was to access the effects of deletion of a key TGF-beta
Autor:
James B. Mitchell, Praveen R. Arany, Kathleen C. Flanders, John A. Cook, Anita B. Roberts, William DeGraff
Publikováno v:
Journal of Dermatological Science. 48:35-42
Summary Background Transforming growth factor-β1 (TGF-β1), a key biological mediator following ionizing radiation, plays a role in a complex tissue reaction involved in local radiation-induced pathological damage. Knocking out Smad3 (S3KO), a downs
Autor:
Christina H. Stuelten, Akira Ooshima, Kathleen C. Flanders, Fang Tian, Stacey DaCosta Byfield, Anita B. Roberts, Shizuya Saika
Publikováno v:
Cytokine & Growth Factor Reviews. 17:19-27
Smads2 and 3 transduce signals of TGF-beta from the cell surface to the nucleus. We used mice with a targeted deletion of Smad3 to study the specific contributions of this signaling pathway to pathogenic effects of TGF-beta. Focusing on models involv