Zobrazeno 1 - 10
of 299
pro vyhledávání: '"Anita B Roberts"'
Autor:
Christina H Stuelten, Johanna I Busch, Binwu Tang, Kathleen C Flanders, Akira Oshima, Emily Sutton, Tatiana S Karpova, Anita B Roberts, Lalage M Wakefield, John E Niederhuber
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9832 (2010)
Carcinoma are complex societies of mutually interacting cells in which there is a progressive failure of normal homeostatic mechanisms, causing the parenchymal component to expand inappropriately and ultimately to disseminate to distant sites. When a
Externí odkaz:
https://doaj.org/article/d15b19825f5f427fac40762a3c937a65
Publikováno v:
BioTechniques, Vol 43, Iss 3, Pp 289-294 (2007)
Canonical TGF-β is involved in cell differentiation, tissue maintenance, and wound healing, but also plays a central role in the pathogenesis of diseases such as cancer. Here we describe a lentivirus-based reporter vector system expressing green flu
Externí odkaz:
https://doaj.org/article/a1b3e2a71f0b4b798fc67d9f9e6791aa
Autor:
David C. Beebe, Ramya Rajagopal, Vesa Kaartinen, Jie Huang, Anita B. Roberts, Lieve Umans, Chu-Xia Deng, Lisa K. Dattilo, Yuji Mishina, An Zwijsen, Ying Liu
Publikováno v:
Development. 136:1741-1750
There are conflicting reports about whether BMP signaling is required for eyelid closure during fetal development. This question was addressed using mice deficient in BMP or TGFβ signaling in prospective eyelid and conjunctival epithelial cells. Gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40634cbd4bc0de5420cecdab041b245
https://doi.org/10.1242/dev.034082
https://doi.org/10.1242/dev.034082
Autor:
David M. Harlan, Seong-Jin Kim, Heather W. Collins, Anil K. Kamaraju, Huei-Min Lin, Franz M. Matschinsky, Duan Zhigang, Sushil G. Rane, Hariom Yadav, Eric Liu, Anita B. Roberts, Ji-Hyeon Lee, Anthony Vieira
Publikováno v:
Journal of Biological Chemistry. 284:12246-12257
Pancreatic islet beta-cell dysfunction is a signature feature of Type 2 diabetes pathogenesis. Consequently, knowledge of signals that regulate beta-cell function is of immense clinical relevance. Transforming growth factor (TGF)-beta signaling plays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a29deb22e968e89b0a64438ae7a1e1
https://doi.org/10.1074/jbc.m805379200
https://doi.org/10.1074/jbc.m805379200
Autor:
Ryan Katz, Lalage M. Wakefield, Misako Sato, Anita B. Roberts, Christina H. Stuelten, Adrian Barbul, Emily Sutton, John E. Niederhuber, Johanna Busch
Publikováno v:
Cancer Research. 68:7278-7282
We investigated the influence of acute wounding on tumor growth in a syngeneic mouse breast cancer model. Metastatic mouse breast cancer cells (4T1) were orthotopically injected into the mammary fat pads of BALB/c mice, and animals were wounded local
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043892de10bcd0ed2ef2b46dabf2b6bf
https://doi.org/10.1158/0008-5472.can-08-1842
https://doi.org/10.1158/0008-5472.can-08-1842
Publikováno v:
Oncogene. 27:2507-2512
The ability of transforming growth factor-beta (TGF-beta) to modulate various effects on distinct cell lineages has been a central feature of its multi-faceted nature. The purpose of this study was to access the effects of deletion of a key TGF-beta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167fe7509362c228b700d658a8c68906
https://doi.org/10.1038/sj.onc.1210889
https://doi.org/10.1038/sj.onc.1210889
Autor:
James B. Mitchell, Praveen R. Arany, Kathleen C. Flanders, John A. Cook, Anita B. Roberts, William DeGraff
Publikováno v:
Journal of Dermatological Science. 48:35-42
Summary Background Transforming growth factor-β1 (TGF-β1), a key biological mediator following ionizing radiation, plays a role in a complex tissue reaction involved in local radiation-induced pathological damage. Knocking out Smad3 (S3KO), a downs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94af4d715c436d56a61fa60c5ac1db14
https://doi.org/10.1016/j.jdermsci.2007.05.012
https://doi.org/10.1016/j.jdermsci.2007.05.012
Autor:
Christina H. Stuelten, Akira Ooshima, Kathleen C. Flanders, Fang Tian, Stacey DaCosta Byfield, Anita B. Roberts, Shizuya Saika
Publikováno v:
Cytokine & Growth Factor Reviews. 17:19-27
Smads2 and 3 transduce signals of TGF-beta from the cell surface to the nucleus. We used mice with a targeted deletion of Smad3 to study the specific contributions of this signaling pathway to pathogenic effects of TGF-beta. Focusing on models involv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ab44f31baf4e57de349a6348f91e78
https://doi.org/10.1016/j.cytogfr.2005.09.008
https://doi.org/10.1016/j.cytogfr.2005.09.008
Publikováno v:
The Journal of Immunology. 174:2061-2070
We previously demonstrated that agents known to signal infection or inflammation can rapidly and directly drive differentiation of human CD14+ monocytes into CD83+ dendritic cells (DCs) when introduced to cells under serum-free conditions. In this st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a67523910af10373328a12c3873f9b66
https://doi.org/10.4049/jimmunol.174.4.2061
https://doi.org/10.4049/jimmunol.174.4.2061