Reversible covalent c-Jun N-terminal kinase inhibitors targeting a specific cysteine by precision-guided Michael-acceptor warheads

Autor: Dániel Bálint, Ádám Levente Póti, Anita Alexa, Péter Sok, Krisztián Albert, Lili Torda, Dóra Földesi-Nagy, Dániel Csókás, Gábor Turczel, Tímea Imre, Eszter Szarka, Ferenc Fekete, Isabel Bento, Márton Bojtár, Roberta Palkó, Pál Szabó, Katalin Monostory, Imre Pápai, Tibor Soós, Attila Reményi

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Abstract There has been a surge of interest in covalent inhibitors for protein kinases in recent years. Despite success in oncology, the off-target reactivity of these molecules is still hampering the use of covalent warhead-based strategies. Herein,

Externí odkaz: https://doaj.org/article/a3e63eb44b28449ba2031704dd9ee83f

A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host

Autor: Anita Alexa, Péter Sok, Fridolin Gross, Krisztián Albert, Evan Kobori, Ádám L. Póti, Gergő Gógl, Isabel Bento, Ersheng Kuang, Susan S. Taylor, Fanxiu Zhu, Andrea Ciliberto, Attila Reményi

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)

The herpesvirus protein ORF45 can bind the two host kinases ERK and RSK but how this affects cell signalling is unclear. Here, the authors show that ORF45 hijacks the ERK-RSK complex by binding to the two kinases with optimized linear motifs and inte

Externí odkaz: https://doaj.org/article/b1961af753104939b45873b5e2d5dcfc

Peptide Based Inhibitors of Protein Binding to the Mitogen-Activated Protein Kinase Docking Groove

Autor: Anita Alexa, Orsolya Ember, Ildikó Szabó, Yousef Mo’ath, Ádám L. Póti, Attila Reményi, Zoltán Bánóczi

Publikováno v: Frontiers in Molecular Biosciences, Vol 8 (2021)

Mitogen-activated protein kinases (MAPK) are important regulatory units in cells and they take part in the regulation of many cellular functions such as cell division, differentiation or apoptosis. All MAPKs have a shallow docking groove that interac

Externí odkaz: https://doaj.org/article/10a444f3e4e44098bd54465bfa952cd0

Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38

Autor: Wolfgang Peti, Attila Reményi, Klára Kirsch, Isabel Bento, Péter Egri, Anita Alexa, Ganesan Senthil Kumar, Orsolya Tőke, Ashish Sethi, Péter Sok, András Zeke, Paul R. Gooley, Anna Sebő, Ádám Póti

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications 11(1), 5769 (2020). doi:10.1038/s41467-020-19582-3
Nature Communications

Nature Communications 11(1), 5769 (2020). doi:10.1038/s41467-020-19582-3
Transcription factor phosphorylation at specific sites often activates gene expression, but how environmental cues quantitatively control transcription is not well-understo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65e55fcf11cc31de830e4b204cf66ca
https://doaj.org/article/8e3a384b4b1a49a98424465168b5b1a6

MAP Kinase Mediated Activation of RSK1 and MK2 Substrate Kinases

Autor: Zoltán Gáspári, Anna Sebő, László Drahos, Gergő Gógl, Ganesan Senthil Kumar, Attila Reményi, Péter Sok, Anita Alexa, Neha Singh, Klára Kirsch, Wolfgang Peti

Publikováno v: SSRN Electronic Journal.

Mitogen activated protein kinases (MAPKs) control essential eukaryotic signaling pathways. While much has been learned about MAPK activation, much less is known about substrate recruitment and specificity. MAPK substrates may be other kinases that ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68ec822aa797b6f782db44d94af143ba
https://doi.org/10.2139/ssrn.3547608