Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Anita, Schultz"'
Publikováno v:
Cellular Signalling. 103:110568
Acidic lipid extracts from mouse liver, kidney, heart, brain, and lung inhibited human pseudoheterodimeric adenylyl cyclases (hACs) expressed in HEK293 cells. Using an acidic lipid extract from bovine lung, a combined MS- and bioassay-guided fraction
Autor:
Anubha Seth, Marius Landau, Andrej Shevchenko, Sofia Traikov, Anita Schultz, Sherif Elsabbagh, Joachim E. Schultz
Nine mammalian adenylyl cyclases (AC) are pseudoheterodimers with two hexahelical membrane domains which are isoform-specifically conserved. Previously we proposed that these membrane domains are orphan receptors (10.7554/eLife.13098; 10.1016/j.cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2577d2e252cadf8dfca668f7790c82d0
https://doi.org/10.1101/2022.02.23.481604
https://doi.org/10.1101/2022.02.23.481604
Autor:
Anita Schultz, Stephanie Beltz, Jens Bassler, Andrei N. Lupas, Joachim E. Schultz, Miriam Ziegler
Publikováno v:
The FEBS Journal. 284:1204-1217
Adenylate cyclases (ACs) are signaling proteins that produce the second messenger cAMP. Class III ACs comprise four groups (class IIIa-d) of which class IIIa and IIIb ACs have been identified in bacteria and eukaryotes. Many class IIIa ACs are anchor
Autor:
Markus O. Zimmermann, Ursula Kurz, Joachim E. Schultz, Ana Banjac, Frank M. Boeckler, Anita Schultz
Publikováno v:
Cellular Signalling. 24:629-634
The dimeric mammalian phosphodiesterases (PDEs) are regulated by N-terminal domains. In PDE5, the GAF-A subdomain of a GAF-tandem (GAF-A and -B) binds the activator cGMP and in PDE10 GAF-B binds cAMP. GAF-tandem chimeras of PDE5 and 10 in which the 3
Publikováno v:
Journal of Biological Chemistry. 287:1022-1031
HAMP domains, ∼55 amino acid motifs first identified in histidine kinases, adenylyl cyclases, methyl-accepting chemotaxis proteins, and phosphatases, operate as signal mediators in two-component signal transduction proteins. A bioinformatics study
Autor:
Anita Schultz, Ying Lan Guo, Dorothea Dittrich, Hermann A. Mayer, Peter Sander, Waldemar Vollmer, Joachim E. Schultz
Publikováno v:
FEBS Journal. 276:1094-1103
cAMP generation in bacteria is often stimulated by sudden, but lasting, changes in extracellular conditions, whereas intracellular cAMP concentrations quickly settle at new levels. As bacteria lack G-proteins, it is unknown how bacterial adenylate cy
Autor:
Anita Schultz, Joachim E. Schultz, Arnulf Stenzl, Florian Altenberend, Marco Gross-Langenhoff
Publikováno v:
FEBS Journal. 275:1643-1650
The tandem GAF domain of human phosphodiesterase 11A4 (hPDE11A4) requires 72 μm cGMP for half-maximal effective concentration (EC50) of a cyanobacterial adenylyl cyclase used as a reporter enzyme. Here we examine whether modifications in the N-termi
Publikováno v:
FEBS Journal. 274:1514-1523
The C-terminal catalytic domains of the 11 mammalian phosphodiesterase families (PDEs) are important drug targets. Five of the 11 PDE families contain less well-characterized N-terminal GAF domains. cGMP is the ligand for the GAF domains in PDEs 2, 5
Autor:
Markus Gruber, Michael Hulko, Joachim E. Schultz, Franziska Berndt, Jürgen U. Linder, Anita Schultz, Andrei N. Lupas, Vincent Truffault, Jörg Martin, Murray Coles
Publikováno v:
Cell. 126(5):929-940
SummaryHAMP domains connect extracellular sensory with intracellular signaling domains in over 7500 proteins, including histidine kinases, adenylyl cyclases, chemotaxis receptors, and phosphatases. The solution structure of an archaeal HAMP domain sh
Publikováno v:
Journal of Biological Chemistry. 281:2841-2846
N-terminal tandem GAF domains are present in 5 out of 11 mammalian phosphodiesterase (PDE) families. The ligand for the GAF domains of PDEs 2, 5, and 6 is cGMP, whereas those for PDEs 10 and 11 remained enigmatic for years. Here we used the cyanobact