Differential intracellular transport and binding of verotoxin 1 and verotoxin 2 to globotriaosylceramide‐containing lipid assemblies

Autor: Patty Tam, Radhia Mahfoud, Anita Nutikka, Paul Paroutis, Aye Aye Khine, Beth Binnington, Clifford A. Lingwood

Publikováno v: Journal of Cellular Physiology. 216:750-763

Although verotoxin-1 (VT1) and verotoxin-2 (VT2) share a common receptor, globotriaosyl ceramide (Gb3), VT2 induces distinct animal pathology and is preferentially associated with human disease. Moreover VT2 cytotoxicity in vitro is less than VT1. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9b7acbcdbc829df3485be966085bfe
https://doi.org/10.1002/jcp.21456

The treatment of malignant meningioma with verotoxin

Autor: Anita Nutikka, Clifford A. Lingwood, Wouter R. van Furth, James T. Rutka, Bodour Salhia

Publikováno v: Neoplasia (New York, N.Y.), 4(4), 304-311. Elsevier Inc.
Neoplasia: An International Journal for Oncology Research, Vol 4, Iss 4, Pp 304-311 (2002)

Malignant meningiomas (MMs) are aggressive intracranial neoplasms with a 75% 5-year recurrence rate. Verotoxin 1 (VTi) is an Escherichia coli toxin, which has recently been shown to have anti-neoplastic action by targeting the globotriosylceramide (G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b552fd4040569130f5358971b7a3019c
https://doi.org/10.1038/sj.neo.7900243

Verotoxin targets lymphoma infiltrates of patients with post-transplant lymphoproliferative disease

Autor: Silviu Grisaru, Michael Dosch, Gerald Arbus, Anita Nutikka, Orit Segal, Prateek Lala, Clifford A. Lingwood, Magdalena Pop

Publikováno v: Leukemia Research. 24:857-864

Post-transplant lymphoproliferative disease (PTLD) is an invasive, EBV expressing B lymphoma and a major cause of morbidity and mortality following organ transplantation. Presently there is limited therapy available; rather the patient often loses th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94a5d0e853499f1c26b206c6d68eed1
https://doi.org/10.1016/s0145-2126(00)00060-6

A comparison of the effects of verocytotoxin-1 on primary human renal cell cultures

Autor: Debora Barnett Foster, Beth Boyd, Clifford A. Lingwood, C. Mark Taylor, Julie M. Williams, David V. Milford, Anita Nutikka

Publikováno v: Toxicology Letters. 105:47-57

Infection with verocytotoxin-producing Escherichia coli causes haemolytic uraemic syndrome (HUS). Verocytotoxin-1 (VT1) is cytopathic to renal microvascular endothelial cells in culture, supporting the hypothesis that the vasculopathy of HUS is cause

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d48b031485a41aa72dd23ed7bcdbf6
https://doi.org/10.1016/s0378-4274(98)00383-x

Brefeldin A and filipin distinguish two globotriaosyl ceramide/verotoxin-1 intracellular trafficking pathways involved in Vero cell cytotoxicity

Autor: Clifford A. Lingwood, Patty Tam, Aye Aye Khine, Anita Nutikka

Publikováno v: Glycobiology. 14(8)

In verotoxin 1 (VT1)-sensitive cells, globotriaosyl ceramide (Gb 3 ) bound VT1 is endocytosed and transported retrogradely to the Golgi/endoplasmic reticulum (ER). The importance of the Golgi-dependent retrograde transportof VT1 is now shown to vary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0859993ec46d0c83bf72cdf6122f10f2
https://pubmed.ncbi.nlm.nih.gov/15102715