Early inflammation as a footprint of increased mortality risk in infants living with HIV from three African countries

Autor: Elena Morrocchi, Giuseppe R. Pascucci, Nicola Cotugno, Chiara Pighi, Sara Dominguez-Rodriguez, Maria Raffaella Petrara, Alfredo Tagarro, Louise Kuhn, Mark F. Cotton, Kennedy Otwombe, Maria G. Lain, Paula Vaz, Shaun L. Barnabas, Moira J. Spyer, Elisa Lopez, Sheila Fernández-Luis, Tacilta Nhampossa, Almoustapha I. Maiga, Oumar Dolo, Anita De Rossi, Pablo Rojo, Carlo Giaquinto, Mathias Lichterfeld, Avy Violari, Theresa Smit, Osee Behuhuma, Nigel Klein, Lesley De Armas, Savita Pahwa, Paolo Rossi, Paolo Palma, EPIICAL consortium

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)

Abstract In this work our aim was to identify early biomarkers in plasma samples associated with mortality in children with perinatal HIV treated early in life, to potentially inform early intervention targeting this vulnerable group. 20/215 children

Externí odkaz: https://doaj.org/article/286d2b323b6a46dda53e87d76b376c7c

The importance of taking ART appropriately in children and adolescents with HIV-1 to reach the highest capacity of immune function later in life

Autor: Katrine Schou Sandgaard, Triantafylia Gkouleli, Teresa Attenborough, Stuart Adams, Deena Gibbons, Mette Holm, Sarah Eisen, Helen Baxendale, Anita De Rossi, Savita Pahwa, Benny Chain, Athina S. Gkazi, Nigel Klein

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Current antiretroviral therapy (ART) guidelines recommend treating all children with HIV-1 infection. This has changed from the broader use of ART to treat children to improve morbidity and minimise mortality. However, prior to current recommendation

Externí odkaz: https://doaj.org/article/5fc8bdfdb716412eb392436e496c945b

Assessing the Variability of Cell-Associated HIV DNA Quantification through a Multicenter Collaborative Study

Autor: Yann Le Duff, Kathleen Gärtner, Eloise J. Busby, Annalisa Dalzini, Sivapragashini Danaviah, José Luis Jiménez Fuentes, Carlo Giaquinto, Jim F. Huggett, Matthew Hurley, Anne-Geneviève Marcellin, María Ángeles Muñoz-Fernández, Denise M. O’Sullivan, Deborah Persaud, Laura Powell, Peter Rigsby, Paolo Rossi, Anita de Rossi, Lilly Siems, Theresa Smit, Sarah A. Watters, Neil Almond, Eleni Nastouli

Publikováno v: Microbiology Spectrum, Vol 10, Iss 3 (2022)

ABSTRACT Reliable and accurate quantification of cell-associated HIV DNA (CA HIV DNA) is critical for early infant diagnosis, clinical management of patients under therapy, and to inform new therapeutics efficacy. The present study assessed the varia

Externí odkaz: https://doaj.org/article/94c480c573cc4c8dacfb127ce8fbdce8

Determinants of B-Cell Compartment Hyperactivation in European Adolescents Living With Perinatally Acquired HIV-1 After Over 10 Years of Suppressive Therapy

Autor: Alessandra Ruggiero, Giuseppe Rubens Pascucci, Nicola Cotugno, Sara Domínguez-Rodríguez, Stefano Rinaldi, Alfredo Tagarro, Pablo Rojo, Caroline Foster, Alasdair Bamford, Anita De Rossi, Eleni Nastouli, Nigel Klein, Elena Morrocchi, Benoit Fatou, Kinga K. Smolen, Al Ozonoff, Michela Di Pastena, Katherine Luzuriaga, Hanno Steen, Carlo Giaquinto, Philip Goulder, Paolo Rossi, Ofer Levy, Savita Pahwa, Paolo Palma, the EPIICAL Consortium, Mark Cotton, Shaun Barnabas, Thanyawee Puthanakit, Louise Kuhn, Andrew Yates, Avy Violari, Kennedy Otwombe, Paula Vaz, Maria Grazia Lain, Tacilta Nampossa, Denise Naniche, Sheila Fernandez-Luis, Elisa Lopez, Holly Peay, Moira Spyer, Vincent Calvez, Anne-Genevieve Marcelin, Maria Angeles Munoz, Annalisa Dalzini, Raffaella Petrara, Kathleen Gartner, Lesley De Armas, Pahwa Rajendra, Suresh Pallikkuth, Deborah Persaud, Nicolas Chomont, Mathias Lichterfeld, Silvia Faggion, Daniel Gomez Pena, Andrea Oletto, Alessandra Nardone, Paola Zangari, Silvia Di Cesare, Chiara Medri, Olga Kolesova, Carla Paganin, William James, Inger Lindfors - Rossi, Shrabon Samiur Hassan, Francesca Mazzetto, Hellen Akisinku, Musakanya Chingandu, Francesca Rocchi, Ilaria Pepponi, Rob J. De Boer, Juliane Schroter, Viviana Giannuzzi, Sinead Morris

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

BackgroundDespite a successful antiretroviral therapy (ART), adolescents living with perinatally acquired HIV (PHIV) experience signs of B-cell hyperactivation with expansion of ‘namely’ atypical B-cell phenotypes, including double negative (CD27

Externí odkaz: https://doaj.org/article/4c3438cc6e094cf89b7fa756b480c8ba

Biological Predictors of De Novo Tumors in Solid Organ Transplanted Patients During Oncological Surveillance: Potential Role of Circulating TERT mRNA

Autor: Michela Cangemi, Stefania Zanussi, Enrica Rampazzo, Ettore Bidoli, Silvia Giunco, Rosamaria Tedeschi, Chiara Pratesi, Debora Martorelli, Mariateresa Casarotto, Ferdinando Martellotta, Ornella Schioppa, Diego Serraino, Agostino Steffan, Anita De Rossi, Riccardo Dolcetti, Emanuela Vaccher

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

BackgroundDe novo tumors are a major cause of morbidity and mortality after long-term solid organ transplantation. Chronic immunosuppression strongly affects solid organ transplanted (SOT) patients’ immune system by promoting immune evasion strateg

Externí odkaz: https://doaj.org/article/3974af58536b4864a9890e01e5005254