Intestinal organoids to model Salmonella infection and its impact on progenitors

Autor: Jin Yan, Claire Racaud-Sultan, Tiffany Pezier, Anissa Edir, Corinne Rolland, Coralie Claverie, Julien Burlaud-Gaillard, Michel Olivier, Philippe Velge, Sonia Lacroix-Lamandé, Nathalie Vergnolle, Agnès Wiedemann

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)

Abstract In order to survive and replicate, Salmonella has evolved mechanisms to gain access to intestinal epithelial cells of the crypt. However, the impact of Salmonella Typhimurium on stem cells and progenitors, which are responsible for the abili

Externí odkaz: https://doaj.org/article/d3ee979c7b5441f8aef55395c3368a2a

Active thrombin produced by the intestinal epithelium controls mucosal biofilms

Autor: Jean-Paul Motta, Alexandre Denadai-Souza, David Sagnat, Laura Guiraud, Anissa Edir, Chrystelle Bonnart, Mireille Sebbag, Perrine Rousset, Ariane Lapeyre, Carine Seguy, Noa Mathurine-Thomas, Heather J. Galipeau, Delphine Bonnet, Laurent Alric, Andre G. Buret, John L. Wallace, Antoine Dufour, Elena F. Verdu, Morley D. Hollenberg, Eric Oswald, Matteo Serino, Celine Deraison, Nathalie Vergnolle

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

The roles played by thrombin in the human intestinal mucosa are unclear. Here, the authors show that the commensal microbiota modulates epithelial production of active thrombin, which controls biofilm growth and contributes to protection of the mucos

Externí odkaz: https://doaj.org/article/68a8589ee36440b4a7b451d28d77ced9

Colitis Linked to Endoplasmic Reticulum Stress Induces Trypsin Activity Affecting Epithelial Functions

Autor: Delphine Bonnet, Nathalie Vergnolle, Sylvain Kirzin, Corinne Rolland, Muriel Quaranta-Nicaise, Alexandre Denadai-Souza, Anissa Edir, Laurent Alric, Nuria Sola Tapias, Emmanuel Mas, Gilles Dietrich, Marlène Marcellin, Frédérick Barreau, Carla Cirillo, Céline Deraison, Claire Rolland-Fourcade, Odile Burlet-Schiltz, Chrystelle Bonnart, Catherine Blanpied, Guillaume Portier

Publikováno v: Journal of Crohn's and Colitis
Journal of Crohn's and Colitis, Elsevier-Oxford University Press, 2021, 15 (9), pp.1528-1541. ⟨10.1093/ecco-jcc/jjab035⟩
Journal of Crohn's and Colitis, 2021, 15 (9), pp.1528-1541. ⟨10.1093/ecco-jcc/jjab035⟩

Background and Aims Intestinal epithelial cells [IECs] from inflammatory bowel disease [IBD] patients exhibit an excessive induction of endoplasmic reticulum stress [ER stress] linked to altered intestinal barrier function and inflammation. Colonic t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d81c08f8443906ef21b3e53fcd6a5c
https://hal.inrae.fr/hal-03510555

SERCA2 Dysfunction in Darier Disease Causes Endoplasmic Reticulum Stress and Impaired Cell-to-Cell Adhesion Strength: Rescue by Miglustat

Autor: Anissa Edir, Alain Hovnanian, Laure Guibbal, Marina Simón, Magali Savignac

Publikováno v: Journal of Investigative Dermatology. 134:1961-1970

Darier disease (DD) is a severe dominant genetic skin disorder characterized by the loss of cell-to-cell adhesion and abnormal keratinization. The defective gene, ATP2A2 , encodes sarco/endoplasmic reticulum (ER) Ca 2+ -ATPase isoform 2 (SERCA2), a C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0020f52cc9d477820b8bcab5df9670
https://doi.org/10.1038/jid.2014.8

P100 Intestinal epithelial cells under endoplasmic reticulum stress boosts serine proteolytic activity and modulates barrier function

Autor: Frédérick Barreau, Anissa Edir, Gilles Dietrich, Corinne Rolland, Alexandre Denadai-Souza, Céline Deraison, N. Solà Tapias, Chrystelle Bonnart, Nathalie Vergnolle, Catherine Blanpied, Claire Rolland-Fourcade

Publikováno v: Journal of Crohn's and Colitis. 11:S127-S127

Background: Studies on ulcerative colitis (UC) patients show an excessive induction of endoplasmic reticulum stress (ERS) in intestinal epithelial cells (IEC) of the colonic mucosa, leading to intestinal barrier disruption and inflammation. Moreover,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a321f39a373b92372ec90fce430a0039
https://doi.org/10.1093/ecco-jcc/jjx002.226