Výsledky vyhledávání - "Anissa Djedid"

Akademický článek

Combined PD-L1 and TIM3 blockade improves expansion of fit human CD8+ antigen-specific T cells for adoptive immunotherapy

Autor: Shirin Lak, Valérie Janelle, Anissa Djedid, Gabrielle Boudreau, Ann Brasey, Véronique Lisi, Ali Smaani, Cédric Carli, Lambert Busque, Vincent-Philippe Lavallée, Jean-Sébastien Delisle

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 230-245 (2022)

Antigen-specific T cell expansion ex vivo followed by adoptive transfer enables targeting of a multitude of microbial and cancer antigens. However, clinical-scale T cell expansion from rare precursors requires repeated stimulation, which may lead to

Externí odkaz: https://doaj.org/article/69663426dd644361ad6f2f2b985cbce2

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Akademický článek

Loss of function mutation of Eftud2, the gene responsible for mandibulofacial dysostosis with microcephaly (MFDM), leads to pre-implantation arrest in mouse.

Autor: Marie-Claude Beauchamp, Anissa Djedid, Kevin Daupin, Kayla Clokie, Shruti Kumar, Jacek Majewski, Loydie Anne Jerome-Majewska

Publikováno v: PLoS ONE, Vol 14, Iss 7, p e0219280 (2019)

Mutations in EFTUD2 are responsible for the autosomal dominant syndrome named MFDM (mandibulofacial dysostosis with microcephaly). However, it is not clear how reduced levels of EFTUD2 cause abnormalities associated with this syndrome. To determine i

Externí odkaz: https://doaj.org/article/412905e3589f4083b86131b0c47d5a1e

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Supplementary Tables S1-S5 from Epigenomic Reordering Induced by Polycomb Loss Drives Oncogenesis but Leads to Therapeutic Vulnerabilities in Malignant Peripheral Nerve Sheath Tumors

Autor: Benjamin A. Garcia, Jacek Majewski, Amanda Lisby, Anissa Djedid, Simone Sidoli, Dylan M. Marchione, John B. Wojcik

Tabbed excel spreadsheet with each tab representing a single supplementary table. The first cell of each tab contains a description of the contents. Supplemental Table 1: Log2 normalized protein abundances of proteins identified in FFPE MPNST samples

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9429dd576b702b266af587d9817e39
https://doi.org/10.1158/0008-5472.22421621.v1

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Data from Epigenomic Reordering Induced by Polycomb Loss Drives Oncogenesis but Leads to Therapeutic Vulnerabilities in Malignant Peripheral Nerve Sheath Tumors

Autor: Benjamin A. Garcia, Jacek Majewski, Amanda Lisby, Anissa Djedid, Simone Sidoli, Dylan M. Marchione, John B. Wojcik

Malignant peripheral nerve sheath tumor (MPNST) is an aggressive sarcoma with recurrent loss-of-function alterations in polycomb-repressive complex 2 (PRC2), a histone-modifying complex involved in transcriptional silencing. To understand the role of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ae3041ed34aee9a0435889c9c96d34e
https://doi.org/10.1158/0008-5472.c.6510974.v1

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Mutation in Eftud2 causes craniofacial defects in mice via mis-splicing of Mdm2 and increased P53

Autor: Jennifer L. Fish, Kym M. Boycott, Fjodor Merkuri, Peter C. Stirling, Rachel Aber, Matthew A. Lines, Eric Bareke, Marie-Claude Beauchamp, Anissa Djedid, Loydie A. Jerome-Majewska, Annie S. Tam, Jacek Majewski

Publikováno v: Hum Mol Genet

EFTUD2 is mutated in patients with mandibulofacial dysostosis with microcephaly (MFDM). We generated a mutant mouse line with conditional mutation in Eftud2 and used Wnt1-Cre2 to delete it in neural crest cells. Homozygous deletion of Eftud2 causes b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84fc86628f55fca1c543387b382980e0
https://doi.org/10.1093/hmg/ddab051

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Combined PD-L1 and TIM-3 blockade improves the expansion of fit human CD8+ antigen-specific T cells for adoptive immunotherapy

Autor: Anissa Djedid, Lambert Busque, Véronique Lisi, Jean-Sébastien Delisle, Valérie Janelle, Ann Brasey, Vincent-Philippe Lavallée, Shirin Lak, Gabrielle Boudreau, Cédric Carli

BackgroundThe stimulation and expansion of antigen-specific T cells ex vivo enables the targeting of a multitude of cancer antigens. However, clinical scale T-cell expansion from rare precursors requires repeated stimulations ex vivo leading to T-cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69f5207fdd31befbebaed580b0e1c1c7
https://doi.org/10.1101/2021.08.30.21262835

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