Výsledky vyhledávání

P862 Clinical benefit potentially evident with immunopharmacodynamic responses in prior-checkpoint failed metastatic melanoma patients treated with imprime PGG and pembrolizumab

Autor: Anissa Chan, Nandita Bose, Nadine Ottoson, Xiaohong Qiu, Ben Harrison, Richard Walsh, Paulette Mattson, Michele Gargano, Joanna Cox, Michael Chisamore, Mark Uhlik, Jeremy Graff

Publikováno v: Poster Presentations.

Background Checkpoint inhibitor (CPI) monotherapy has revolutionized the treatment of melanoma, yet most patients are primary nonresponders or develop secondary resistance. Lack of antigen-specific T cell priming and/or immunosuppressive mechanisms l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e207b671d37d257aa1567df2a906c7ac
https://doi.org/10.1136/lba2019.15

Zobrazit plný text záznamu

Family Hardship Following Youth Concussion: Beyond the Medical Bills

Autor: Matthew Li, Anissa Chan, Monica S. Vavilala, Wendy Williams-Gilbert, Leanne Kehoe, Janessa M. Graves, Megan Moore, Kelsey M. Conrick

Publikováno v: J Pediatr Nurs

Purpose The costs facing families after pediatric concussion are not limited to medical expenses for treatment and rehabilitation care. The objective of this research was to examine the economic hardship facing families following concussion. Design a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2d885c82c99bb21df979a2d518677ea
https://pubmed.ncbi.nlm.nih.gov/31838221

Zobrazit plný text záznamu

Self‐organisation and capacity building: sustaining the change

Autor: Alan Bain, Anissa Chan, Allan David Walker

Publikováno v: Journal of Educational Administration. 49:701-719

PurposeThe paper aims to describe the application of theoretical principles derived from a study of self‐organisation and complex systems theory and their application to school‐based capacity building to support planned change.Design/methodology/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebd798e0210c4c695c1a5692ecc03963
https://doi.org/10.1108/09578231111174839

Zobrazit plný text záznamu

Imprime PGG, a yeast β-glucan immunomodulator has the potential to modulate the subtypes of immunosuppressive M2 macrophages (TUM6P.962)

Autor: Nandita Bose, Xiaohong Qiu, Adria Jonas, Anissa Chan, Takashi Kangas, Jeremy Graff

Publikováno v: The Journal of Immunology. 194:141.10-141.10

Imprime PGG (IPGG) is a yeast β-1,3/1,6 glucan that, when complexed with endogenous anti-β-glucan antibodies, binds and primes neutrophils and monocytes to exert cytotoxic activity against antibody-targeted cancer cells via a complement receptor 3-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f15f86afa029f432970631ad5f75cfc
https://doi.org/10.4049/jimmunol.194.supp.141.10

Zobrazit plný text záznamu

Endogenous anti-β-glucan antibodies, a potential predictive biomarker for the efficacy of soluble yeast β-1,3/1,6 glucan (Imprime PGG®) immunotherapy in cancer patients (VAC3P.947)

Publikováno v: The Journal of Immunology. 192:73.9-73.9

The innate immune response to Imprime PGG® (Imprime PGG) is being leveraged to develop a novel cancer immunotherapy in conjunction with anti-tumor monoclonal antibodies. Previous research has demonstrated the presence of endogenous anti-β-glucan an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67f7ff51705de0cf23b92f8e0deac4b1
https://doi.org/10.4049/jimmunol.192.supp.73.9

Zobrazit plný text záznamu

Recognition of soluble yeast β-1,3/1,6 glucan by complement receptor 1 is essential for it to bind complement receptor 3 on human neutrophils and monocytes, and complement receptor 2 on B cells (P3048)

Autor: Nandita Bose, Anissa Chan, Adria Bykowski Jonas, Xiaohong Qiu, William Grossman

Publikováno v: The Journal of Immunology. 190:125.2-125.2

β-glucans are considered as fungal pathogen-associated molecular patterns that are recognized by innate human cells. Our previous studies demonstrated that Imprime PGG®, an analytically well-characterized form of yeast-derived soluble β−glucan,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e933e291a8f0dc591d4d69f320a90a3
https://doi.org/10.4049/jimmunol.190.supp.125.2

Zobrazit plný text záznamu

Binding of soluble yeast β-1,3/1,6 glucans to complement receptors leads to immunomodulatory effects on both innate and adaptive human immune cells (55.8)

Autor: William Grossman, Anissa Chan, Keith Gorden, Adria Bykowski-Jonas, Richard Walsh, Katie Ertelt, John Vasilakos, Mary Antonysamy, Nadine Ottoson, Nandita Bose

Publikováno v: The Journal of Immunology. 188:55.8-55.8

β-glucans are considered as fungal pathogen-associated molecular patterns (PAMPs) that are recognized by cells of the human innate immune system. Few studies have focused on recognition and immunostimulatory functions of soluble β-glucan (sβG) on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78dbd2c2cefd5f563b23b8682f266fdf
https://doi.org/10.4049/jimmunol.188.supp.55.8

Zobrazit plný text záznamu

Human innate immune cells that engage soluble beta-1,3/1,6 glucans: Role for complement receptor 3 (CR3, CD11b/CD18) (89.53)

Autor: John Vasilakos, Nandita Bose, Anissa Chan, Michael Danielson, Christine Dudney, Natalie Elmasry, Keith Gorden, Faimola Guerrero, Andy Magee, Carolyn Maristany, Richard Walsh, Paul Will, Lindsay Wurst

Publikováno v: The Journal of Immunology. 184:89.53-89.53

Beta-1,3/1,6 glucans (BGs) are a diverse class of PAMPs. Structurally, BGs can vary on the basis of chain length, types of linkages, branching, and tertiary structure. BGs have been reported to activate various types of innate immune cells; most stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc8ce6c2a7994929c6f6f2845d2d29b2
https://doi.org/10.4049/jimmunol.184.supp.89.53

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání