Výsledky vyhledávání - "Anissa, Chikh"

Akademický článek

Neuropilin-1 Controls Endothelial Homeostasis by Regulating Mitochondrial Function and Iron-Dependent Oxidative Stress

Autor: Theo Issitt, Emy Bosseboeuf, Natasha De Winter, Neil Dufton, Gaia Gestri, Valentina Senatore, Anissa Chikh, Anna M. Randi, Claudio Raimondi

Publikováno v: iScience, Vol 11, Iss , Pp 205-223 (2019)

Summary: The transmembrane protein neuropilin-1 (NRP1) promotes vascular endothelial growth factor (VEGF) and extracellular matrix signaling in endothelial cells (ECs). Although it is established that NRP1 is essential for angiogenesis, little is kno

Externí odkaz: https://doaj.org/article/3d93fbcc84b445d396a8543ea382f882

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Akademický článek

p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response

Autor: Paola Arcidiacono, Catherine M. Webb, Matthew A. Brooke, Huiqing Zhou, Paul J. Delaney, Keat-Eng Ng, Diana C. Blaydon, Andrew Tinker, David P. Kelsell, Anissa Chikh

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Mutations in the gene encoding iRHOM2 are associated with hyperproliferative epidermal disorders. Here, the authors show that iRHOM2 is a target gene of p63, that together they regulate inflammation, cell survival and response to oxidative stress, an

Externí odkaz: https://doaj.org/article/c3aea6eca2d04247a2f4d1f9bed1b658

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Akademický článek

Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16

Autor: Thiviyani Maruthappu, Anissa Chikh, Benjamin Fell, Paul J. Delaney, Matthew A. Brooke, Clemence Levet, Angela Moncada-Pazos, Akemi Ishida-Yamamoto, Diana Blaydon, Ahmad Waseem, Irene M. Leigh, Matthew Freeman, David P. Kelsell

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

Keratin 16 is an epithelial protein highly expressed at pressure bearing sites and during wound healing and cancer. Here the authors show that K16 interacts with the inactive protease Rhbdf2, associated with Tylosis with oesophageal cancer, and that

Externí odkaz: https://doaj.org/article/b4cfedfe8b0b4b1e98605a9262df868a

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Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow

Autor: Emy Bosseboeuf, Anissa Chikh, Ahmed Bey Chaker, Tom P. Mitchell, Dhilakshani Vignaraja, Ridhi Rajendrakumar, Rayomand S. Khambata, Thomas D. Nightingale, Justin C. Mason, Anna M. Randi, Amrita Ahluwalia, Claudio Raimondi

Publikováno v: Science Signaling. 16

Linear and disturbed flow differentially regulate gene expression, with disturbed flow priming endothelial cells (ECs) for a proinflammatory, atheroprone expression profile and phenotype. Here, we investigated the role of the transmembrane protein ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f71cea6628d093ee38aebd574d9bc2e
https://doi.org/10.1126/scisignal.abo4863

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Constitutive Autophagy and Nucleophagy during Epidermal Differentiation

Autor: Katherine Sully, Anissa Chikh, Carolyn Byrne, Michael P. Philpott, O Akinduro, Daniele Bergamaschi, Catherine A. Harwood, Kristin M. Braun, Deborah J. Robinson, Ryan F.L. O'Shaughnessy, Graham McPhail, Ankit Kumar Patel

Publikováno v: Journal of Investigative Dermatology. 136:1460-1470

Epidermal keratinocytes migrate through the epidermis up to the granular layer where, on terminal differentiation, they progressively lose organelles and convert into anucleate cells or corneocytes. Our report explores the role of autophagy in ensuri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5db0869da6cc653936a1628826ab9fae
https://doi.org/10.1016/j.jid.2016.03.016

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Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1–dependent ABL1 activation in endothelial cells

Autor: Claudio Raimondi, Anastasia Lampropoulou, Christiana Ruhrberg, Laura Denti, Alessandro Fantin, Anissa Chikh

Publikováno v: The Journal of Experimental Medicine

Neuropilin 1 regulates angiogenesis in a VEGF-independent manner via association with ABL1, suggesting that Imatinib represents a novel opportunity for anti-angiogenic therapy.
To enable new blood vessel growth, endothelial cells (ECs) express n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2329dbb45f782b6510030bacac4b6a
http://europepmc.org/articles/PMC4042645

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