Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Anisha Zaveri"'
Autor:
Siddharth Subramaniyam, Michael A. DeJesus, Anisha Zaveri, Clare M. Smith, Richard E. Baker, Sabine Ehrt, Dirk Schnappinger, Christopher M. Sassetti, Thomas R. Ioerger
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-15 (2019)
Abstract Background Deep sequencing of transposon mutant libraries (or TnSeq) is a powerful method for probing essentiality of genomic loci under different environmental conditions. Various analytical methods have been described for identifying condi
Externí odkaz:
https://doaj.org/article/c80d20f8c434430692d7e045fc78bfc1
Autor:
Esha Dutta, Michael A DeJesus, Nadine Ruecker, Anisha Zaveri, Eun-Ik Koh, Christopher M Sassetti, Dirk Schnappinger, Thomas R Ioerger
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0257911 (2021)
Chemical-genetics (C-G) experiments can be used to identify interactions between inhibitory compounds and bacterial genes, potentially revealing the targets of drugs, or other functionally interacting genes and pathways. C-G experiments involve const
Externí odkaz:
https://doaj.org/article/19a1ca45325a42529d142e9df2c1aa29
Autor:
Thomas R. Ioerger, Kenan C. Murphy, Zimmerman, Soni, Kyu Y. Rhee, Aslebagh R, Nadine Ruecker, Baker Re, Charlotte J. Reames, Scott A. Shaffer, Dirk Schnappinger, Anisha Zaveri, Kristine M. Guinn, Véronique Dartois, Proulx Mk, Carolina Trujillo, Michael Fitzgerald, Deborah T. Hung, Eun-Ik Koh, K. G. Papavinasasundaram, Eric J. Rubin, Christopher M. Sassetti, Sabine Ehrt
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(15)
Current chemotherapy against Mycobacterium tuberculosis (Mtb), an important human pathogen, requires a multidrug regimen lasting several months. While efforts have been made to optimize therapy by exploiting drug-drug synergies, testing new drug comb
Autor:
Michael A. DeJesus, Anisha Zaveri, Kyu Y. Rhee, Dirk Schnappinger, Sabine Ehrt, Jeremy M. Rock, Thomas R. Ioerger, Emanuel Flores-Bautista, Adrian Jinich, Clare M. Smith, Christopher M. Sassetti
Characterization of gene essentiality across different conditions is a useful approach for predicting gene function. Transposon sequencing (TnSeq) is a powerful means of generating genome-wide profiles of essentiality and has been used extensively in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d5a58994f993d0b5469d4b9a6abac29
https://doi.org/10.1101/2021.03.05.434127
https://doi.org/10.1101/2021.03.05.434127
Autor:
Curtis A. Engelhart, Nadine Ruecker, Joshua B. Wallach, Jeremy M. Rock, Wenzhu Zhang, Brian T. Chait, Shuqi Li, Anisha Zaveri, Sabine Ehrt, Nicholas C. Poulton, Barbara Bosch, Sophie Lavalette, Michael A. DeJesus, Dirk Schnappinger, Carolina Trujillo
Publikováno v:
Cell
Summary Antibacterial agents target the products of essential genes but rarely achieve complete target inhibition. Thus, the all-or-none definition of essentiality afforded by traditional genetic approaches fails to discern the most attractive bacter
Autor:
Anisha Zaveri, Thomas R. Ioerger, Esha Dutta, Eun-Ik Koh, Dirk Schnappinger, Michael A. DeJesus, Nadine Ruecker, Christopher M. Sassetti
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0257911 (2021)
PLoS ONE
PLoS ONE
Chemical-genetics (C-G) experiments can be used to identify interactions between inhibitory compounds and bacterial genes, potentially revealing the targets of drugs, or other functionally interacting genes and pathways. C-G experiments involve const
Autor:
Avipsa Bose, Abinaya Rajendran, Priyanka Biswas, Suruchi Sharma, Avinash R. Shenoy, Sandhya S. Visweswariah, Anisha Zaveri
Publikováno v:
Biophys J
Mycobacteria harbor a unique class of adenylyl cyclases with a complex domain organization consisting of an N-terminal putative adenylyl cyclase domain fused to a nucleotide-binding adaptor shared by apoptotic protease-activating factor-1, plant resi
Autor:
Ritu Sharma, Sabine Ehrt, Robert S. Jansen, Joshua B. Wallach, Ruojun Wang, Laure Botella, Anisha Zaveri, Linnan Zhu, Naomi Song, Kyu Y. Rhee, Dirk Schnappinger
Publikováno v:
Molecular Microbiology, 114, 4, pp. 641-652
Molecular Microbiology
Molecular Microbiology, 114, 641-652
Molecular Microbiology
Molecular Microbiology, 114, 641-652
Of the ~80 putative toxin‐antitoxin (TA) modules encoded by the bacterial pathogen Mycobacterium tuberculosis (Mtb), three contain antitoxins essential for bacterial viability. One of these, Rv0060 (DNA ADP‐ribosyl glycohydrolase, DarGMtb), funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c777d164df0a3fca3814a747f6bd67
https://hdl.handle.net/2066/226327
https://hdl.handle.net/2066/226327
Autor:
Thomas R. Ioerger, Christopher M. Sassetti, Clare M. Smith, Siddharth Subramaniyam, Michael A. DeJesus, Sabine Ehrt, Richard Baker, Anisha Zaveri, Dirk Schnappinger
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-15 (2019)
BMC Bioinformatics
BMC Bioinformatics
BackgroundDeep sequencing of transposon mutant libraries (or TnSeq) is a powerful method for probing essentiality of genomic loci under different environmental conditions. Various analytical methods have been described for identifying conditionally e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60a581f54f4edfd3356160dc97d865e
https://doi.org/10.1101/590281
https://doi.org/10.1101/590281
Autoinhibitory mechanism and activity-related structural changes in a mycobacterial adenylyl cyclase
Autor:
Nikhil Bharambe, Kaza Suguna, Deivanayaga V. Barathy, Sandhya S. Visweswariah, Anisha Zaveri, Sandra Misquith, Melwin Colaςo, Wajeed Syed
Publikováno v:
Journal of Structural Biology. 190:304-313
An adenylyl cyclase from Mycobacterium avium, Mal 120, is a functional orthologue of a pseudogene Rv1120c from Mycobacterium tuberculosis. We report the crystal structure of Mal 120 in a monomeric form and its truncated construct as a dimer. Mal 120