Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Anisha M Loeb"'
Autor:
Quy Le, Brandon Hadland, Jenny L. Smith, Amanda Leonti, Benjamin J. Huang, Rhonda Ries, Tiffany A. Hylkema, Sommer Castro, Thao T. Tang, Cyd N. McKay, LaKeisha Perkins, Laura Pardo, Jay Sarthy, Amy K. Beckman, Robin Williams, Rhonda Idemmili, Scott Furlan, Takashi Ishida, Lindsey Call, Shivani Srivastava, Anisha M. Loeb, Filippo Milano, Suzan Imren, Shelli M. Morris, Fiona Pakiam, Jim M. Olson, Michael R. Loken, Lisa Brodersen, Stanley R. Riddell, Katherine Tarlock, Irwin D. Bernstein, Keith R. Loeb, Soheil Meshinchi
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 22 (2022)
The CBFA2T3-GLIS2 (C/G) fusion is a product of a cryptic translocation primarily seen in infants and early childhood and is associated with dismal outcome. Here, we demonstrate that the expression of the C/G oncogenic fusion protein promotes the tran
Externí odkaz:
https://doaj.org/article/134ccd270d5242848fcfcd4f706249e4
Autor:
Danielle C. Kirkey, Anisha M. Loeb, Sommer Castro, Cyd Nourigat McKay, LaKeisha Perkins, Laura Pardo, Amanda R. Leonti, Thao T. Tang, Michael R. Loken, Lisa Eidenschink Brodersen, Keith R. Loeb, David A. Scheinberg, Quy Le, Soheil Meshinchi
Publikováno v:
Blood Advances. 7:1178-1189
Preferentially Expressed Antigen in Melanoma (PRAME), a cancer-testis antigen, provides an ideal target for immunotherapy in acute myeloid leukemia (AML). We have shown expression of PRAME in a significant subset of childhood and adult AML and lack o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d77d911a8410e62c1149667c59de5c
https://doi.org/10.1182/bloodadvances.2022008304
https://doi.org/10.1182/bloodadvances.2022008304
Hematopoietic stem cell transplantation is a well known treatment of hematologic malignancies wherein nascent stem cells provide a regenerating marrow and immunotherapy against the tumor. The progeny of hematopoietic stem cells also populate a wide s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9fbef53a5a4556a3666beb5ed231d54
https://doi.org/10.1101/2023.04.20.23288326
https://doi.org/10.1101/2023.04.20.23288326
Therapeutic Targeting of Mesothelin with Chimeric Antigen Receptor T Cells in Acute Myeloid Leukemia
Autor:
Katherine Tarlock, Salvatore Fiorenza, Soheil Meshinchi, Lindsey F Call, Quy Le, Cameron J. Turtle, Anisha M Loeb, Cyd Nourigat McKay, Jenny L. Smith, Michael R. Loken, Shivani Srivastava, LaKeisha Perkins, Rhonda E. Ries, Stanley R. Riddell, Amanda R. Leonti, Colin Correnti, Laura Pardo, Thao T. Tang, Tiffany A. Hylkema, Sommer Castro
Publikováno v:
Clinical Cancer Research. 27:5718-5730
Purpose: We previously identified mesothelin (MSLN) as highly expressed in a significant fraction of acute myeloid leukemia (AML) but entirely silent in normal hematopoiesis, providing a promising antigen for immunotherapeutic targeting that avoids h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f065418da887725fff132a03b0ce968c
https://doi.org/10.1158/1078-0432.ccr-21-1546
https://doi.org/10.1158/1078-0432.ccr-21-1546
Autor:
Jay F. Sarthy, Suzan Imren, Brandon Hadland, Soheil Meshinchi, Sommer Castro, Keith R. Loeb, Benjamin J. Huang, Cynthia Nourigat, Scott N. Furlan, LaKeisha Perkins, Shivani Srivastava, Rhonda E. Ries, Thao T Tang, Irwin D. Bernstein, Jenny L. Smith, Lisa Eidenschink Brodersen, Katherine Tarlock, Stanley R. Riddell, Larua Pardo, Lindsey F Call, Amy Beckman, Rhonda Idemmili, Amanda R. Leonti, Tiffany A. Hylkema, Takashi Ishida, Anisha M Loeb, Quy Le, Loken Michael, Robin Williams
Fusion oncoproteins are the initiating event in AML pathogenesis, although they are thought to require additional cooperating mutations for leukemic transformation. CBFA2T3-GLIS2 (C/G) fusion occurs exclusively in infants and is associated with highl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::006f550daf8c2558a104753f1a38f789
https://doi.org/10.21203/rs.3.rs-757279/v1
https://doi.org/10.21203/rs.3.rs-757279/v1
Autor:
Sergio Ruiz, Anisha M. Loeb, Oktay Kirak, Teresa Olbrich, Eros Lazzerini Denchi, Anastasia Lobanova, Marta Markiewicz-Potoczny
Publikováno v:
Nature
In mammals, telomere protection is mediated by the essential protein TRF2, which binds chromosome ends and ensures genome integrity(1,2). TRF2 depletion results in end-to-end chromosome fusions in all cell types that have been tested so far. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56fec9cff272256b6c8ca13f419c068f
https://europepmc.org/articles/PMC9161009/
https://europepmc.org/articles/PMC9161009/
Publikováno v:
Blood. 138:645-645
Introduction: Hematopoietic stem cell transplantation (HSCT) has had a major impact on the treatment of hematologic malignancies. Recent studies have shown the role HSCT can have in gene therapy by providing long-lived genetically modified cells to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76652e0e13615280ec0e48cb9b1aee19
https://doi.org/10.1182/blood-2021-148203
https://doi.org/10.1182/blood-2021-148203
Autor:
Thao T. Tang, Tiffany A. Hylkema, Anisha M Loeb, Cynthia Nourigat-Mckay, Laura Pardo, Amanda R. Leonti, Soheil Meshinchi, Quy Le, LaKeisha Perkins, Sommer Castro, Lindsey F Call, David A. Scheinberg
Publikováno v:
Blood. 138:733-733
Chimeric antigen receptor (CAR) Ts have been effective in pre-B ALL, but their efficacy in AML has yet to be established. A significant barrier to effective CAR T therapy for AML is the substantial overlap of cell surface antigens expressed on AML an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc033e8aa1e6f103c9564a9787218df6
https://doi.org/10.1182/blood-2021-148677
https://doi.org/10.1182/blood-2021-148677
Autor:
Maxwell A, Tracy, Mitchell B, Lee, Brady L, Hearn, Ian T, Dowsett, Luke C, Thurber, Jason, Loo, Anisha M, Loeb, Kent, Preston, Miles I, Tuncel, Niloufar, Ghodsian, Anna, Bode, Thao T, Tang, Andy R, Chia, Alan J, Herr
Publikováno v:
Genetics
Mutations affecting DNA polymerase exonuclease domains or mismatch repair (MMR) generate “mutator” phenotypes capable of driving tumorigenesis. Cancers with both defects exhibit an explosive increase in mutation burden that appears to reach a thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8e7240862eccc5a140d0b9bc39ea5933
https://pubmed.ncbi.nlm.nih.gov/32513814
https://pubmed.ncbi.nlm.nih.gov/32513814
Autor:
Ian T. Dowsett, Jason Loo, Miles I Tuncel, Maxwell A Tracy, Anisha M. Loeb, Kent Preston, Thao T Tang, Anna Bode, Alan J. Herr, Luke C Thurber, Niloufar Ghodsian, Brady L Hearn, Mitchell B. Lee, Andy R. Chia
DNA polymerase (Pol) proofreading and mismatch repair (MMR) defects produce “mutator” phenotypes capable of driving tumorigenesis. “Ultra-mutated” cancers with defects in both pathways exhibit an explosive increase in point mutation burden th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7235f738fe443964dff69baec975bb66